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G1044
Monoclonal Anti-Granzyme B antibody produced in mouse
clone GrB7, tissue culture supernatant
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Synonym(s):
Anti-C11, Anti-CCPI, Anti-CGL-1, Anti-CGL1, Anti-CSP-B, Anti-CSPB, Anti-CTLA1, Anti-CTSGL1, Anti-HLP
Número MDL:
NACRES:
NA.41
Recommended Products
origen biológico
mouse
Nivel de calidad
200
conjugado
unconjugated
forma del anticuerpo
tissue culture supernatant
antibody product type
primary antibodies
clon
GrB7, monoclonal
descripción
not suitable for immunocytochemistry (frozen sections)
mol peso
antigen 33 kDa
species reactivity
human
technique(s)
immunocytochemistry: 1:20 using pretreated tissues
western blot: suitable
Nº de acceso UniProt
enviado en
dry ice
temp. de almacenamiento
−20°C
Gene Information
human ... GZMB(3002)
Especificidad
Does not cross-react with granzyme A.
Inmunógeno
recombinant human granzyme B.
Aplicación
Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.
Acciones bioquímicas o fisiológicas
Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells.[1] It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI).[2] It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspases in vitro and in vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways.[3][4][5] It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.[6]
Forma física
Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
12 - Non Combustible Liquids
WGK
WGK 3
Punto de inflamabilidad F
Not applicable
Punto de inflamabilidad C
Not applicable
Certificate of Analysis
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Certificate of Origin
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Data Sheets
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