This product is soluble in 0.05 M acetic acid (10 mg/ml) as well as water (1 mg/ml).
G1895
Gly-Pro-Arg-Pro
≥95% (HPLC), fibrin polymerization inhibitor
Sinónimos:
GPRP, Glycyl-Prolyl-Arginyl-Proline amide
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5 MG
264,00 €
25 MG
930,00 €
264,00 €
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C18H31N7O5
Número CAS:
Peso molecular:
425.48
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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Permítanos ayudarleNombre del producto
Gly-Pro-Arg-Pro, ≥95% (HPLC)
SMILES string
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
InChI key
WXPZDDCNKXMOMC-AVGNSLFASA-N
assay
≥95% (HPLC)
storage temp.
−20°C
Quality Level
Gene Information
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
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Categorías relacionadas
1 of 4
Este artículo | G1269 | G4391 | G3923 |
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
| Gene Information human ... FN1(2335) | Gene Information human ... ITGA2B(3674), ITGAV(3685) | Gene Information human ... ITGB3(3690) | Gene Information - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Application
Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.[1]
Biochem/physiol Actions
Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin.[2] Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.[3]
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).[4]
Inhibits fibrin polymerization.
General description
Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.[1]
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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N Li et al.
European journal of haematology, 65(1), 57-65 (2000-07-29)
A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets
Harfenist EJ, et al.
Blood, 59(5), 952-955 (1982)
Elena Monzón Manzano et al.
British journal of haematology, 189(5), 943-953 (2020-01-17)
Multifactorial mechanisms leading to diminished platelet counts in immune thrombocytopaenia (ITP) might condition the ability of patients with ITP to respond to treatments. Examining their platelet and immune features, we aimed to detect singular characteristics of patients with ITP who
L Pasalic et al.
Journal of thrombosis and haemostasis : JTH, 16(6), 1198-1210 (2018-03-24)
Essentials Procoagulant platelets can be detected using GSAO in human whole blood. Stable coronary artery disease is associated with a heightened procoagulant platelet response. Agonist-induced procoagulant platelet response is not inhibited by aspirin alone. Collagen plus thrombin induced procoagulant platelet
B Shenkman et al.
The Journal of laboratory and clinical medicine, 135(1), 43-51 (2000-01-19)
Recent studies emphasize the role of blood constituents in Staphylococcus aureus (S. aureus) adherence to subendothelial extracellular matrix. In the present study, the adherence of two strains of S. aureus (ATCC 29213 and RN 6390) grown to a postexponential phase
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Hi. I received fly-pro-arg-pro. G1895 5 mg. CAS-No:67869-629. You don’t mention where to dilute it and how much to dilute the powder in. Can you please help?
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