p-Fluorohexahydro-sila-difenidol hydrochloride

powder, ≥98% (HPLC)

P-F-HHSiD hydrochloride, Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride
Empirical Formula (Hill Notation):
C20H32FNOSi · HCl
Número de CAS:
Peso molecular:
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad



≥98% (HPLC)




white to beige


H2O: slightly soluble 1.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL
ethanol: soluble

SMILES string




InChI key


Gene Information

human ... CHRM3(1131)


10, 50 mg in glass bottle

Acciones bioquímicas o fisiológicas

High affinity M3 muscarinic acetylcholine receptor antagonist.

Características y beneficios

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Información legal

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


NONH for all modes of transport

WGK Alemania


Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

S Pesić et al.
Pharmacology, 64(4), 182-188 (2002-03-15)
The effect of acetylcholine (ACh) on the isolated, nonprecontracted perforating branch of the human internal mammary artery (HIMA) was investigated. ACh induced concentration-dependent contractions of nonprecontracted rings with denuded endothelium (pEC(50) = 6.72 +/- 0.02, E(max) = 88.8% of contractions...
Dora E Benavides-Haro et al.
Naunyn-Schmiedeberg's archives of pharmacology, 368(4), 309-315 (2003-09-10)
The effect of the cholinomimetic agent, bethanechol on macroscopic membrane currents was studied in dispersed cat atrial myocytes, using the whole-cell patch-clamp technique. Bethanechol activated an inward rectifying potassium current similar to I(K(ACh)), and a delayed rectifying-like outward current, similar...
M T de la Vega et al.
Archives of medical research, 28(4), 493-497 (1997-01-01)
In this study, the authors set out to determine the presence of M3 muscarinic receptors in rat striatum by examining the binding of [3H]N-methylscopolamine ([3H]NMS) to striatal membranes and its displacement by antagonists with different affinity for M1 and M3...
Kunrong Cheng et al.
American journal of physiology. Gastrointestinal and liver physiology, 295(3), G591-G597 (2008-07-26)
Most colon cancers overexpress M3 muscarinic receptors (M3R), and post-M3R signaling stimulates human colon cancer cell proliferation. Acetylcholine (ACh), a muscarinic receptor ligand traditionally regarded as a neurotransmitter, may be produced by nonneuronal cells. We hypothesized that ACh release by...
M R Ruggieri et al.
Autonomic & autacoid pharmacology, 26(3), 311-325 (2006-08-02)
1 The M3 muscarinic receptor subtype is widely accepted as the receptor on smooth muscle cells that mediates cholinergic contraction of the normal urinary bladder and other smooth muscle tissues, however, we have found that the M2 receptor participates in...

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