H4644

Hypercalcemia of malignancy factor 1-40 human

Name: Hypercalcemia of malignancy factor 1-40 human
Brand: SIGMA
Price: 163 EUR

≥95% (HPLC), suitable fo drug transporter assays

Sinónimos:

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser, PTH-Like Adenylate Cyclase Stimulating Protein, PTHrP (1-40), Parathyroid hormone-related protein (1-40)

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0.1 MG

163,00 €

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Fórmula empírica (notación de Hill):

C₂₀₇H₃₃₄N₆₆O₅₈

Número CAS:

120298-73-9

Peso molecular:

4675.27

Número MDL:

MFCD00081712

Código UNSPSC:

12352201

NACRES:

NA.26

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Nombre del producto

Hypercalcemia of malignancy factor 1-40 human, ≥95% (HPLC)

Nivel de calidad

200

Ensayo

≥95% (HPLC)

Formulario

solid

técnicas

drug transporter assay: suitable

Nº de acceso UniProt

P12272

temp. de almacenamiento

−20°C

Información sobre el gen

human ... PTHLH(5744)

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Este artículo	H9148	T3410	G2269
Sigma-Aldrich H4644 Hypercalcemia of malignancy factor 1-40 human	Sigma-Aldrich H9148 Hypercalcemia of malignancy factor fragment 1-34 amide human	Sigma-Aldrich T3410 Thymosin α₁ bovine	Sigma-Aldrich G2269 Gastric Inhibitory Polypeptide human
form solid	form solid	form powder	form powder
technique(s) drug transporter assay: suitable	technique(s) drug transporter assay: suitable	technique(s) -	technique(s) ligand binding assay: suitable
assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Quality Level 200	Quality Level 200	Quality Level -	Quality Level 200
UniProt accession no. P12272	UniProt accession no. P12272	UniProt accession no. Q2LDY9	UniProt accession no. P09681

Amino Acid Sequence

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser

Acciones bioquímicas o fisiológicas

Hypercalcemia of malignancy factor fragment 1-40 human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

0000488464

0000471811

039K8715

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Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.

T J Rosol et al.

Domestic animal endocrinology, 8(4), 499-507 (1991-10-01)

The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and adenylate cyclase in vitro. Bovine PTH-(1-34) and human PTHrP-(1-34) were equipotent in their

Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody.

Koh Sato et al.

Seminars in oncology, 30(5 Suppl 16), 167-173 (2003-11-13)

Parathyroid hormone-related protein (PTHrP) plays a central role in humoral hypercalcemia of malignancy (HHM), which is one of the most frequent paraneoplastic syndromes. PTHrP produced by the tumor acts through a common PTH/PTHrP receptor to promote bone resorption, inhibit calcium

Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.

P Esbrit et al.

The Journal of endocrinology, 166(1), 11-20 (2000-06-17)

Parathyroid hormone (PTH)-related protein (PTHrP) is the main factor responsible for humoral hypercalcemia of malignancy. Both PTH and PTHrP bind to the common type I PTH/PTHrP receptor (PTHR), thereby activating phospholipase C and adenylate cyclase through various G proteins, in

Parathyroid hormone-related protein purified from a human lung cancer cell line.

J M Moseley et al.

Proceedings of the National Academy of Sciences of the United States of America, 84(14), 5048-5052 (1987-07-01)

A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN). A major protein band of 18 kDa was obtained on NaDodSO4/polyacrylamide gels, with faint

Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

H L Uy et al.

Cancer research, 57(15), 3194-3199 (1997-08-01)

Humoral hypercalcemia of malignancy results from the effects of tumor-produced factors on bone, kidney, and intestine that disrupt normal calcium homeostasis. Although parathyroid hormone-related protein (PTHrP) is a major mediator of the syndrome, tumors also produce other hypercalcemic factors, such

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Hypercalcemia of malignancy factor 1-40 human