I2786

Sigma-Aldrich

Interleukin-6 human

IL-6, recombinant, expressed in E. coli, Carrier Free

Sinónimos:
IL-6, monocyte derived human B cell growth factor, interferon b2 (IFNb2), Interleukin-6 human, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), plasmacytoma growth factor (PCT-GF), IL6, interleukin hybridoma/plasmacytoma-1 (IL-HP1)
Número MDL:
NACRES:
NA.77

Nivel de calidad

200

origen biológico

human

recombinante

expressed in E. coli

ensayo

>97% (SDS-PAGE)

formulario

lyophilized powder

potencia

0.2-2.0 ng/mL Biological Activity EC50

calidad

Carrier Free

mol peso

26 kDa

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

≤1 EU/μg protein Endotoxin Level

color

white

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Gene Information

human ... IL6(3569)

Categorías relacionadas

Descripción general

Interleukin-6 (IL-6) is a multi-functional 26 kDa protein originally discovered in the medium of RNA-stimulated fibroblastoid cells1. IL-6 appears to be directly
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.

IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.

The product was prepared from raw materials verified to be carrier free.

Aplicación

Human interleukin-6 (IL-6) has been used to study the effects of IL-6, along with IL-8 and IL-1β, on the clot structure of healthy blood.

Acciones bioquímicas o fisiológicas

IL-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

RIDADR

NONH for all modes of transport

WGK Alemania

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1beta, IL-6 and IL-8
Janette B, et al.
Cytokine (2018)
A new interleukin with pleiotropic activities.
T Kishimoto et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 9(1), 11-15 (1988-07-01)
Tadamitsu Kishimoto
Clinical reviews in allergy & immunology, 28(3), 177-186 (2005-09-01)
In the late 1960s, the essential role of T-cells in antibody production was reported. This suggested to us that certain molecules should be released from T-cells for the stimulation of B-cells. We discovered activities in the culture supernatant of T-cells...
Interleukin-6: an overview.
J Van Snick
Annual review of immunology, 8, 253-278 (1990-01-01)
J Van Snick et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(24), 9679-9683 (1986-12-01)
A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas. Hybrids that failed to survive in the absence of this molecule represented a major proportion of rat-mouse hybridomas but were very rare...

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