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Merck

I8898

Ivermectin

α7 neuronal nicotinic acetylcholine receptor modulator, powder

Sinónimos:

22,23-Dihydroavermectin B1, MK-933

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250 MG

55,00 €

1 G

173,00 €

55,00 €

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Número CAS:
70288-86-7
UNSPSC Code:
12352200
PubChem Substance ID:
24278497
NACRES:
NA.77
MDL number:
MFCD00869511
Form:
powder
Quality level:
100

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Nombre del producto

Ivermectin,

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

form

powder

solubility

MEK: 50 mg/mL

antibiotic activity spectrum

parasites

application(s)

agriculture
environmental

mode of action

cell membrane | interferes

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)

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Este artículo
PHR1380I80000101354309
Ivermectin

Sigma-Aldrich

I8898

Ivermectin

Ivermectin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1380

Ivermectin

Ivermectin European Pharmacopoeia (EP) Reference Standard

I8000010

Ivermectin

Ivermectin United States Pharmacopeia (USP) Reference Standard

USP

1354309

Ivermectin

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

MEK: 50 mg/mL

solubility

-

solubility

-

solubility

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-

antibiotic activity spectrum

parasites

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

Application

Ivermectin has been used:
  • in Caenorhabditis elegans fecundity assay[1]
  • in larval development test[2]
  • to measure in vivo topical acaricide activity of compounds in rats[3]
  • to assess its acute and chronic effects to zebrafish[4]
  • in percutaneous drug injection method to treat cystic echinococcosis[5]
  • in liquid chromatography with fluorescence detection method[6]

Biochem/physiol Actions

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Ivermectin is a macro-cyclic lactone,[7] derived from avermectin.[8] It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.[8]

Other Notes

Primarily ivermectin B1a.

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCZ6135
MKCX8161
MKCV0451
MKCM8215
MKCM4277

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Hidden in plain sight-multiple resistant species within a strongyle community
McIntyre J, et al.
Veterinary Parasitology (2018)
Claire L McArthur et al.
Veterinary parasitology, 212(3-4), 292-298 (2015-06-30)
Cyathostomins are the most prevalent parasitic pathogens of equids worldwide. These nematodes have been controlled using broad-spectrum anthelmintics; however, cyathostomin resistance to each anthelmintic class has been reported and populations insensitive to more than one class are relatively commonplace. The
Effects of ivermectin on Danio rerio: a multiple endpoint approach: behaviour, weight and subcellular markers
Domingues I, et al.
Ecotoxicology (London, England), 25(3), 491-499 (2016)
An in vivo rodent model for identifying and characterizing acaricides
Gutierrez JA, et al.
Journal of Medical Entomology, 43(3), 526-532 (2006)
Ivermectin used in percutaneous drug injection method for the treatment of liver hydatid disease in sheep
Hokelek M, et al.
Gastroenterology, 122(4), 957-962 (2002)
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Preguntas

1–6 de 6 Preguntas  

  1. Is product I8898, Ivermectin the analytical standard grade level? if not, what level is it?

    1 respuesta

    1. This product is considered a research grade with an assigned quality level of 100. Other Ivermectin products available are primary or secondary pharmaceutical reference standards. Please see the link below to review additional information regarding product quality levels:
      https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program

      Please see the following link to review alternative Ivermectin standard product options:
      https://www.sigmaaldrich.com/search/ivermectin-standard?focus=products&page=1&perpage=30&sort=relevance&term=ivermectin%20standard&type=product

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  2. What is the solution stability of Ivermectin (Product No. I8898)?

    1 respuesta

    1. Stock solutions of Ivermectin in DMSO at a concentration of 10 mM have been found to be stable for 2 weeks at -20°C, according to Shan, Q., et al., in Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel.  J. Biol. Chem., 276(16), 12556-12564 (2001).

      ¿Le ha resultado útil?

  3. What is the composition of the submoieties B1A and B1B in Product No. I8898, Ivermectin?

    1 respuesta

    1. Unfortunately we do not test each lot to determine the composition.  In the past, lots have been ~95% B1A and ~5% B1B; however there will be lot-to-lot variation.

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  4. How does the storage temperature relate to shipping conditions?

    1 respuesta

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  5. What is the molecular weight of Product No. I8898, Ivermectin?

    1 respuesta

    1. This product is a mixture of two submoieties B1A, MW 891.1 and B1B, MW 877.1. It is typically predominantly B1A, so you may use a molecular weight of 890 in your calculations.

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  6. What is the Department of Transportation shipping information for this product?

    1 respuesta

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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