L9045

Sigma-Aldrich

Lipodisq®

Styrene:Maleic Anhydride Copolymer 3:1

NACRES:
NA.26

Nivel de calidad

200

origen biológico

synthetic

formulario

powder

temp. de almacenamiento

room temp

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Descripción general

Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq® polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

Envase

100 mg in poly bottle

Aplicación

Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.
The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.

Functional pH range: 6.0 - 9.0

Acciones bioquímicas o fisiológicas

Lipodisq® polymers are potentially useful in mitigating the use of detergents for solubilization of membrane proteins. Dissolving this product in an aqueous solution, with sufficient base (e.g. KOH, NaOH), causes hydrolysis of each anhydride moiety into two carboxylic acid/carboxylate groups. This action renders the SMA polymer soluble in aqueous media. Lipodisq® acts as a potential membrane mimic system.

Información legal

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

RIDADR

NONH for all modes of transport

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Indra D Sahu et al.
Biochemistry, 52(35), 5967-5984 (2013-08-22)
Electron paramagnetic resonance (EPR) spectroscopy is a very powerful biophysical tool that can provide valuable structural and dynamic information about a wide variety of biological systems. The intent of this review is to provide a general overview for biochemists and...
Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer Lipodisq particles for functional and biophysical studies
Orwick-Rydmark M, et al.
Nano Letters, 12(9), 4687-4692 (2012)
Juan F Bada Juarez et al.
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer...
Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies
Zhang R, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(1), 329-333 (2015)
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer...

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