Merck
  • M6316
All Photos(1)

M6316

Sigma-Aldrich

MRS 1754 hydrate

≥98% (HPLC), solid

Synonym(s):
8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
Empirical Formula (Hill Notation):
C26H26N6O4 · xH2O
Molecular Weight:
486.52 (anhydrous basis)
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

Análisis

≥98% (HPLC)

formulario

solid

color

off-white

solubilidad

DMSO: soluble >10 mg/mL

temp. de almacenamiento

room temp

SMILES string

O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3

InChI

1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2

InChI key

ZACJDWOPQROWIK-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

1 of 4

This Item
SML0213L1045A2846
MRS 1754 hydrate ≥98% (HPLC), solid

Sigma-Aldrich

M6316

MRS 1754 hydrate

MC2050 hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0213

MC2050 hydrate

Sigma-Aldrich

Sigma-Aldrich

L1045

LY-354740 hydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

solid

color

off-white

color

white to beige

color

-

color

off-white to light tan

solubility

DMSO: soluble >10 mg/mL

solubility

H2O: ≥5 mg/mL at warmed to 60 °C

solubility

deionized water: 8 mg/mL

solubility

H2O: soluble

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Aplicación

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:
  • to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
  • blastema formation in zebrafish
  • to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

Acciones bioquímicas o fisiológicas

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
MRS 1754 hydrate is a potent A2B adenosine receptor antagonist.

Características y beneficios

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información legal

Manufactured and sold under license from Adenosine Therapeutics LLC.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

(enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service