Merck

M7769

Sigma-Aldrich

IgG2a, Kappa from murine myeloma

clone UPC 10, ascites fluid, lyophilized powder

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Sinónimos:
Mouse IgG2a-κ
Número MDL:
NACRES:
NA.46

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

clon

UPC 10, monoclonal

formulario

lyophilized powder

temp. de almacenamiento

2-8°C

target post-translational modification

unmodified

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Este artículo
M9144M1421M7894
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

ascites fluid

clone

UPC 10, monoclonal

clone

UPC 10, monoclonal

clone

TEPC 15, monoclonal

clone

MOPC 21, monoclonal

form

lyophilized powder

form

buffered aqueous solution

form

buffered aqueous solution

form

lyophilized powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Descripción general

The UPC-10 tumor line that produces mouse IgG2a, K is a tetramethylpentadecane (pristane) induced plasmacytoma originated and carried intraperitoneally in BALB/c mice. The hapten binding specificity of the UPC-10 line is for β-2-6-linked fructosan. The ascites produced from the UPC-10 tumor line contains IgG2a, K in addition to normal levels of other mouse immunoglobulins and serum proteins. The ascites fluid is clarified by centrifugation and filtration. IgG2a (immunoglobulin G 2a) is one of the subclasses of rat immunoglobulins, which also include IgG1, IgG2b and IgG2c.

Especificidad

Antigen Specificity: β-2,6-fructosan

Trace amounts of lambda chain may be present.

Inmunógeno

The UPC-10 tumor line that produces mouse IgG2a, K is a tetramethylpentadecane (pristane) induced plasmacytoma originated and carried intraperitoneally in BALB/c mice.

Aplicación

IgG2a, Kappa from murine myeloma has been used in immunofluorescence and immunohistochemistry.

Acciones bioquímicas o fisiológicas

The IgG2a (immunoglobulin G 2a) plays a vital role in stimulating autoimmunity in mice. This gene is expressed at high level during virus infection. IgG2a offers host defence through activation of complement system. This antibody has specificity towards Fc receptors expressed on phagocytes and stimulates antibody-dependent cell mediated cytotoxicity. IgG2a also induces macrophage-mediated opsonophagocytosis, which has been observed in response to influenza virus and leads to its clearance from the infected cells.

Forma física

The product provided is lyophilized from 0.01 M phosphate buffered saline, pH 7.2, with no preservatives added.

Nota de preparación

Storage and Stability: Store the product at 2-8 °C. After reconstitution, the solution may be stored frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage clarify the solution by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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S Escotte et al.
The European respiratory journal, 21(4), 574-581 (2003-05-24)
Inhaled fluticasone propionate (FP) is widely used to reduce pulmonary inflammation in chronic obstructive pulmonary disease, but the potential effects of FP on airway epithelial cells from patients with cystic fibrosis (CF) are unknown. In CF disease, a nonregulated inflammatory
Non-sunscreen photoprotection: antioxidants add value to a sunscreen.
Matsui M S, et al.
The Journal of Investigative Dermatology. Symposium Proceedings / The Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 14(1), 56-59 (2009)
N Reddy et al.
Cancer immunology, immunotherapy : CII, 46(1), 25-33 (1998-03-31)
We reported previously that the blood clearance of injected mouse IgG2a was extremely rapid in many strains of nude and nu/+ mice. In an attempt to determine the cause of this phenomenon, the levels of endogenous IgG2a in the blood
Three classes and four (sub) classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c.
Bazin H, et al.
European Journal of Immunology, 4(1), 44-48 (1974)
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.
Savitsky D A, et al.
Proceedings of the National Academy of Sciences of the USA, 201005599-201005599 (2010)

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