Merck
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M9269

Sigma-Aldrich

IgG1, Kappa from murine myeloma

clone MOPC 21, purified immunoglobulin, buffered aqueous solution

Sinónimos:
Mouse IgG1-κ
Número MDL:

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

clon

MOPC 21, monoclonal

formulario

buffered aqueous solution

enviado en

dry ice

temp. de almacenamiento

−20°C

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Especificidad

Specificity is determined by mouse monoclonal isotyping strips. The purified immunoglobulin preparation is non-reactive with anti mouse IgA, IgM, IgG2a, IgG2b or IgG3

Aplicación

IgG1, κ from murine myeloma has been used in:
  • the in situ hybridization experiments with bulbar conjunctiva sections
  • immunohistochemistry of cattle and artery tissues
IgG1, Kappa from murine myeloma has been used in flow cytometric analysis and immunoprecipitation.
IgG1, κ from murine myeloma has been used:
  • in immunofluorescence of leukocytes at a concentration of 50 μg/ml
  • as a standard in enzyme linked immunosorbent assay (ELISA)
  • as exchange antibody in centrifugal gel filtration

Acciones bioquímicas o fisiológicas

IgG1 has a molecular weight of 146 kDa and is an abundantly expressed IgG subclass. IgG1 deficiencies contribute to overall decrease in total IgG levels resulting in hypogammaglobulinemia. IgG1 promotes bacterial phagocytosis and mediates vaccine-induced protection from infection. The ratio of IgG2a to IgG1 is crucial for the immune response against Leishmania tropica infection. It has high binding affinity towards the Fcγ receptors (FcγR). High levels of IgG1-κ antibodies is associated with the pathology of glomerulonephritis.
IgG antibody subtype is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.

Forma física

Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide

Almacenamiento y estabilidad

Store at −20 °C. The product may be stored frozen in working aliquots at −20 °C. Repeated freezing and thawing is not recommended.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificado de Análisis

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Certificado de origen

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Quotes and Ordering

G G de Sá Oliveira et al.
Clinical and experimental immunology, 105(2), 313-320 (1996-08-01)
The specificities of a panel of erythrocyte-reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by immunoprecipitation and immunoblotting. Of the eight antibodies, two (IgG1 MoAb 105-2H and IgG2a MoAb 34-3C) immunoprecipitated a 105-kD component identified
Circulating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis.
Vankalakunti M, et al.
Indian journal of nephrology, 27(4), 327-327 (2017)
Phillip A Doerfler et al.
Clinical immunology (Orlando, Fla.), 158(2), 140-147 (2015-04-07)
Antibodies formed against the therapeutic protein are a life-threatening complication that arises during enzyme replacement therapy for Pompe disease (acid α-glucosidase deficiency; GAA). To provide an effective alternative to current practices, we investigated the capacity of anti-B-cell activating factor (BAFF)
The relative contribution of mast cell subsets to conjunctival TH2-like cytokines.
Anderson DF, et al.
Investigative Ophthalmology & Visual Science, 42(5), 995-1001 (2001)
M Dellian et al.
British journal of cancer, 82(9), 1513-1518 (2000-05-02)
Molecular charge is one of the main determinants of transvascular transport. There are, however, no data available on the effect of molecular charge on microvascular permeability of macromolecules in solid tumours. To this end, we measured tumour microvascular permeability to

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