N1162

Sigma-Aldrich

NS3763

≥98% (HPLC), solid

Sinónimos:
5-Carboxy-2,4-dibenzamidobenzoic acid
Empirical Formula (Hill Notation):
C22H16N2O6
Número de CAS:
Peso molecular:
404.37
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

solid

color

off-white

solubilidad

DMSO: ~24 mg/mL

temp. de almacenamiento

2-8°C

SMILES string

OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3

InChI

1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)

InChI key

UUDYZUDTQPLDDP-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

First non-competitive antagonist of GluK5 receptor.

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Katherine Waters et al.
Developmental biology, 344(2), 1011-1025 (2010-07-06)
Proliferating germ cells in Caenorhabditiselegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling, we identified approximately 200 genes upregulated in the proliferating germ cells of C. elegans. Functional...
Péter Erdélyi et al.
Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)
Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the important developmental and medical...
Saravanapriah Nadarajan et al.
Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)
Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for...
Katherine R Schouest et al.
PloS one, 4(10), e7450-e7450 (2009-10-15)
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been...
Peter E A Ash et al.
Human molecular genetics, 19(16), 3206-3218 (2010-06-10)
RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model...

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