Merck
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N5755

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide phosphate hydrate

Synonym(s):
β-NADP, Coenzyme II, NADP, TPN, Triphosphopyridine nucleotide
Empirical Formula (Hill Notation):
C21H28N7O17P3 · xH2O
CAS Number:
Molecular Weight:
743.41 (anhydrous basis)
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.51

ensayo

≥95% (HPLC)
≥95% (spectrophotometric assay)

Nivel de calidad

200

formulario

powder

solubilidad

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

trazas de catión

sodium and potassium: ≤0.04%

temp. de almacenamiento

−20°C

SMILES string

O.NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H28N7O17P3.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);1H2/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1

InChI key

ZKJOXOJMGXFSPF-QYZPTAICSA-N

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Aplicación

β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in:
  • the measurement of Glucose-6-phosphate dehydrogenase activity[1]
  • the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system[2]
  • the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system[3]
  • the determination of Glucose-6-phosphate content[4]

Envase

100, 250, 500 mg in glass bottle
1 g in glass bottle

Acciones bioquímicas o fisiológicas

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation.[5] The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).[6]
Electron acceptor

Otras notas

Packaged based on solid weight.
This is a common form of NADP.

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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