P0049

Sigma-Aldrich

Pyronaridine tetraphosphate

Sinónimos:
2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
Empirical Formula (Hill Notation):
C29H32ClN5O2·4H3PO4
Número de CAS:
Peso molecular:
910.03
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.85

Nivel de calidad

100

Modo de acción

enzyme | interferes

espectro de actividad antibiótica

parasites

temp. de almacenamiento

2-8°C

SMILES string

OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.COc1ccc2nc3cc(Cl)ccc3c(Nc4cc(CN5CCCC5)c(O)c(CN6CCCC6)c4)c2n1

InChI

1S/C29H32ClN5O2.4H3O4P/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35;4*1-5(2,3)4/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32);4*(H3,1,2,3,4)

InChI key

YKUQEKXHQFYULM-UHFFFAOYSA-N

Categorías relacionadas

Aplicación

Pyronaridine, an acridine derivative, is used in China as a treatment for drug-resistant falciparum malaria. It′s in vitro activities have been studied against Plasmodium falciparum in Cameroon.

Envase

250 mg in glass bottle

Acciones bioquímicas o fisiológicas

Pyronaridine has antimalarial activity and is used in conjunction with artensunate. It is antagonistic against naphthoquine and dihydroartemisinin. Pyronaridine blocks B-hematin formation in vitro and has inhibitory activity toward P-glycoprotein mediated drug resistance.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RIDADR

NONH for all modes of transport

WGK Alemania

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Matthias Rottmann et al.
Antimicrobial agents and chemotherapy, 64(4) (2020-02-12)
Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose combinations. Assessing the pharmacodynamic interactions of potential antimalarial drug combination partners during early...
Leonardo K Basco et al.
Antimicrobial agents and chemotherapy, 47(4), 1391-1394 (2003-03-26)
The spread of chloroquine-resistant Plasmodium falciparum calls for a constant search for new drugs. The in vitro activity of piperaquine, a new Chinese synthetic drug belonging to the bisquinolines, was evaluated in 103 fresh clinical isolates of P. falciparum in...
Timothy M E Davis et al.
Antimicrobial agents and chemotherapy, 50(8), 2883-2885 (2006-07-28)
In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA...
Giorgia Mori et al.
Tuberculosis (Edinburgh, Scotland), 112, 98-109 (2018-09-13)
The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against Mycobacterium tuberculosis (MIC...
Mohamed Abdo Rizk et al.
Scientific reports, 7(1), 12774-12774 (2017-10-19)
In this study, we evaluated the validity of a fluorescence-based assay using SYBR Green I (SG I) stain for screening antibabesial compounds against B. microti in mice. Two different hematocrits (HCTs; 2.5% and 5%) were used. Correlating relative fluorescence units...

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