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Merck

P1750

Sigma-Aldrich

Pancreatina from porcine pancreas

4 × USP specifications

Sinónimos:

Pancreatina from hog pancreas

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25 G
51,10 €
100 G
131,00 €
500 G
465,00 €

51,10 €


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Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54

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Agency

USP (specifications)

Nivel de calidad

Formulario

powder

actividad específica

4 × USP specifications

contiene

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

temp. de almacenamiento

−20°C

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1 of 4

Este artículo
P7545P32921.07133
specific activity

4 × USP specifications

specific activity

8 × USP specifications

specific activity

4 × USP specifications

specific activity

-

form

powder

form

powder

form

powder

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

500

agency

USP (specifications)

agency

-

agency

USP (specifications)

agency

Ph. Eur., USP

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

contains

lactose as extender

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

contains

-

Aplicación

Pancreatin from porcine pancreas has been used:
  • for a study to assess the treatment of steatorrhea by lipase supplementation therapy[1]
  • for a study to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis[2]
  • to safely and effectively remove formalin-fixed tissues from arterial grafts without causing structural damage and loss in fiber integrity [3]
  • to assess cleavage by digestive enzymes.
  • for in vitro digestibility analysis and to test the sensitivities of cellulolytic bacteria inhibitors.[4]
  • along with amyloglucosidase for the in vitro digestion of starch in food samples.[5]

Acciones bioquímicas o fisiológicas

La pancreatina contiene componentes enzimáticos, como la tripsina, la amilasa y las lipasas, las ribonucleasas y las proteasas, producidas por las células exocrinas de páncreas porcino. Esta combinación de enzimas permite hidrolizar las proteínas, el almidón y las grasas. La pancreatina convertirá no menos de 25 veces su peso de almidón de patata en carbohidratos solubles en 5 minutos en agua a 40 °C, digerirá no menos de 25 veces su peso de caseína en 60 minutos a pH 7,5 a 40 °C y liberará no menos de microequivalentes de ácido por minuto por miligramo de pancreatina del aceite de oliva a pH 9,0 y 37 °C.

Pictogramas

Health hazardExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Peter Layer et al.
Pancreas, 26(1), 1-7 (2002-12-25)
Treatment of steatorrhea by lipase supplementation therapy has become more successful in the last decade due to better understanding of the physiology and pathophysiology of the digestive process. Porcine lipase has been the therapeutic standard for several decades and will
David C Whitcomb et al.
Digestive diseases and sciences, 52(1), 1-17 (2007-01-06)
A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the
Muhammad Awais et al.
Foods (Basel, Switzerland), 9(5) (2020-05-28)
The changes in structure and digestion properties of mung bean starch due to hydrothermal treatment at various controlled temperatures were investigated. Results showed the increase in onset temperature (To) from 66.33 °C to 76.69 °C and decrease in enthalpies (∆Hg
Gabriele Rocchetti et al.
Antioxidants (Basel, Switzerland), 9(4) (2020-04-10)
In this work, different commercial extra-virgin olive oils (EVOO) were subjected to in vitro gastrointestinal digestion and the changes in bioactive compounds were evaluated by ultra-high-pressure liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry, using untargeted metabolomics. As expected, raw EVOO
Asavela Ngalavu et al.
Animals : an open access journal from MDPI, 10(4) (2020-04-17)
Feed fiber composition is usually considered as one of the factors that have an impact on digestive tract microbiota composition. The investigations on the level of fermentation and in-vitro digestibility of different fibers are not well understood. The aim of

Preguntas

1–4 de 4 Preguntas  
  1. units of pancreatin cas number 8049-47-6

    1 respuesta
    1. This product meets 4X the minimum USP specifications. According to the USP monograph for Pancreatin, the 1X minimum specification is 25 USP units amylase, 2 USP units lipase, and 25 USP units protease per milligram. The calculated protease activity for the 4X preparation then, would be at least 100 units per milligram. This is a calculated value based on the USP monograph and are not reported separately on the Certificate of Analysis.

      ¿Le ha resultado útil?

  2. What is the trypsin activity of this P1750 product ?

    1 respuesta
    1. This product is not specifically tested for trypsin activity. The material meets USP requirements. This monograph includes testing for protease, amylase, and lipase.

      ¿Le ha resultado útil?

  3. What is the solubility of p1750 pancreatin in water?

    1 respuesta
    1. This product is soluble at 7 mg/mL in water and may yield a hazy solution.

      ¿Le ha resultado útil?

  4. As per USP: Pancreatin contains, in each mg, not less than 25 USP Units of protease activity. I assume that product P1750 contains minimum 100 USP units of protease activity in each mg. What is the maximum USP units of protease activity in P1750 ?

    1 respuesta
    1. Yes, this is correct. To meet the USP specifications, the protease activity will be less than 100 USP Units/mg.

      ¿Le ha resultado útil?

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