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P7097

Sigma-Aldrich

Monoclonal Anti-Interleukin-4−R-Phycoerythrin antibody produced in mouse

clone 3007.11, purified immunoglobulin, buffered aqueous solution

Sinónimos:
Monoclonal Anti-Interleukin-4, Anti-IL-4
NACRES:
NA.41

Nivel de calidad

200

origen biológico

mouse

conjugado

phycoerythrin (R-PE) conjugate

forma del anticuerpo

purified immunoglobulin

antibody product type

primary antibodies

clon

3007.11, monoclonal

formulario

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: suitable

isotipo

IgG1

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

2-8°C

Gene Information

human ... IL4(3565)

Especificidad

The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.

Inmunógeno

recombinant human IL-4

Acciones bioquímicas o fisiológicas

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Conjugation of R-Phycoerythrin to the antibody enables its use in immunofluorescent techniques.

Forma física

25 μg of antibody in 1.0 mL of saline containing up to 0.5% bovine serum albumin. Contains 0.1% sodium azide as a preservative.

Nota de preparación

Purified antibody is conjugated to R-phycoerythrin (PE).

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Certificado de origen

Jane Gilmour et al.
Immunology, 124(4), 437-444 (2008-05-16)
The mechanism of differentiation of naïve T cells to a variety of effector lineages, but particularly to T helper type 1 (Th1) and Th2 cells, has been the subject of intense scrutiny over the past two decades. Studies have revealed
Hao-Wei Wang et al.
Cell cycle (Georgetown, Tex.), 9(24), 4824-4835 (2010-12-15)
Although macrophages were originally recognized as major immune effector cells, it is now appreciated that they also play many important roles in the maintenance of tissue homeostasis, and are involved in a variety of pathological conditions including cancer. Several studies
H Jiang et al.
The Journal of allergy and clinical immunology, 105(6 Pt 1), 1063-1070 (2000-06-16)
In the past several years, extensive studies on the mechanisms underlying IL-4 and IL-13 signaling have enabled us to gain insight into how these cytokines regulate immune responses. Because both IL-4 and IL-13 use the IL-4Ralpha as a receptor component

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