Merck
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P8783

Sigma-Aldrich

Progesterone

powder, BioReagent, suitable for cell culture

Sinónimos:
4-Pregnene-3,20-dione
Empirical Formula (Hill Notation):
C21H30O2
Número de CAS:
Peso molecular:
314.46
Beilstein:
1915950
Número de EC:
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad

200

origen biológico

synthetic (organic)

descripción

synthesized from materials derived from plant source

línea de producto

BioReagent

ensayo

≥99%

formulario

powder

potencia

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubilidad

absolute ethanol: 1 mg/mL

temp. de almacenamiento

room temp

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

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Categorías relacionadas

Descripción general

Progesterone is a steroid hormone secreted by the ovaries.

Aplicación

Progesterone has been used:
  • as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
  • to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
  • as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Envase

1, 5, 25 g in glass bottle

Acciones bioquímicas o fisiológicas

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Otras notas

Steroid hormone produced by the corpus luteum.

Forma física

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitución

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Carc. 2 - Lact. - Repr. 1A

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Certificado de Análisis

Introduzca el número de lote para buscar un certificado de análisis (COA).

Certificado de origen

Introduzca el número de lote para buscar un Certificado de origen (COO).

Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
Internalization of coxsackievirus A9 is mediated by beta2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
Heikkila O, et al.
Journal of Virology, 84(7), 3666-3681 (2010)
Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)

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