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PRS3335

Sigma-Aldrich

Anti-Bcl-2 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:
Anti-B-cell CLL/lymphoma 2
Número MDL:
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

antibody product type

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−20°C

Gene Information

human ... BCL2(596)

Descripción general

B-cell lymphoma 2 (BCL2), a proto-oncogene is made of three exons. It is widely expressed in immature B-cells and memory B cells. BCL2 is found at high levels in the thymus, spleen, and lymph nodes. BCL2 gene is mapped to human chromosome 18q21.33.

Inmunógeno

a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.

Aplicación

Anti-Bcl-2 (ab1) antibody produced in rabbit has been used in western blotting (1:100) (1:1000), immunohistochemistry (1:50), immunoprecipitation (IP) (1:1000)

Acciones bioquímicas o fisiológicas

B-cell lymphoma 2 (BCL2) plays a key role in maintaining the integrity of the mitochondrial membrane. It blocks the release of cytochrome C and its binding to apoptosis activating factor-1 (APAF1). BCL2 family proteins participate in modulating cell death. It also regulates apoptosis, necrosis, and autophagy. Upregulation of BCL2 is seen in several human cancers. Overexpression of BCL2 is observed in chronic lymphocytic leukemia (CLL), marginal cell lymphoma, and mantle cell lymphoma.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3335.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Yudi Han et al.
International journal of molecular medicine, 41(2), 800-808 (2017-12-06)
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Ping He et al.
International journal of molecular medicine, 45(4), 1261-1269 (2020-03-04)
The authors' previous studies demonstrated that the major renal damage from hepatitis B virus infection is HBx‑induced apoptosis of renal tubular epithelial cells. Cordyceps sinensis is one of the most valuable of traditional Chinese medicines and is extensively used to treat
Leilei Yu et al.
Experimental and therapeutic medicine, 12(4), 2275-2280 (2016-10-05)
Diabetes is a metabolic disease that results from impairment in insulin secretion. The present study aimed to investigate the potential role of NOM1 in the function of pancreatic islet β cells and insulin secretion. MIN6 cells isolated from mice were
Ziying Zhang et al.
Acta biochimica Polonica, 67(3), 359-365 (2020-08-28)
Spinal cord injury (SCI) is a neurological trauma that causes loss of locomotor function and sensory deficit. Previous studies showed that miRNAs play a crucial role in SCI. This study further evaluated the potential role of miR-139-5p in the neural
Jiao Zheng et al.
Cancer management and research, 11, 5231-5242 (2019-06-27)
Background: Hepatocellular carcinoma (HCC) is a particularly prevalent type of liver cancer and is one of the deadliest malignancies in Asia. Tangeretin is a biological compound extracted from traditional Chinese herbs and has been shown to have potential antitumour properties;

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