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PRS3627

Sigma-Aldrich

Anti-LAMP-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Sinónimos:
Anti-Lysosomal-associated membrane protein 2
Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

reactividad de especies

mouse, human

técnicas

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

mouse ... Lamp2(16784)

Descripción general

Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.

Inmunógeno

a 17 amino acid peptide from near the center of human LAMP-2.

Aplicación

Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Acciones bioquímicas o fisiológicas

LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3627.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Damaghi M, et al.
Nature Communications, 6:8752 (2015)
Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo
Jaadane I, et al.
Journal of Cellular and Molecular Medicine (2017)
Unique properties of lamp2a compared to other lamp2 isoforms
Cuervo AM and Dice JF
Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)
Imene Jaadane et al.
Journal of cellular and molecular medicine, 21(12), 3453-3466 (2017-07-01)
Ageing and alteration of the functions of the retinal pigment epithelium (RPE) are at the origin of lost of vision seen in age-related macular degeneration (AMD). The RPE is known to be vulnerable to high-energy blue light. The white light-emitting
Characterization of stress response in human retinal epithelial cells.
Giansanti V
Journal of Cellular and Molecular Medicine, 17(1), 103-115 (2013)

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