SAB4200759

Anti-Human IgG3 antibody, Mouse monoclonal

Name: Anti-Human IgG3 antibody, Mouse monoclonal
Brand: SIGMA

clone HP-6050, purified from hybridoma cell culture

Sinónimos:

Anti-Immunoglobulin G3

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NACRES:

NA.43

UNSPSC Code:

12352203

Clone:

HP-6050, monoclonal

Species reactivity:

human

Application:

ELISA (i), IP

Citations:

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biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

HP-6050, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 1-2.5 μg/test using Human IgG3 myeloma, indirect ELISA: 0.15-0.3 μg/mL using 1 μg/ml Human IgG3 myeloma for coating

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

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Este artículo	SAB4200788	SAB4200786	I7260
Sigma-Aldrich SAB4200759 Anti-Human IgG3 antibody, Mouse monoclonal	Sigma-Aldrich SAB4200788 Anti-Human IgG1 (Fc specific) antibody, Mouse monoclonal	Sigma-Aldrich SAB4200786 Anti-Human IgG1 antibody, Mouse monoclonal	Sigma-Aldrich I7260 Monoclonal Anti-Human IgG3 antibody produced in mouse
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity -
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form ascites fluid
clone HP-6050, monoclonal	clone HP-6001, monoclonal	clone 8C/6-39, monoclonal	clone HP-6050, monoclonal
technique(s) immunoprecipitation (IP): 1-2.5 μg/test using Human IgG3 myeloma, indirect ELISA: 0.15-0.3 μg/mL using 1 μg/ml Human IgG3 myeloma for coating	technique(s) indirect ELISA: 0.5 μg/mL using 1 μg/mL Human IgG1 myeloma protein for coating.	technique(s) indirect ELISA: 3-6 μg/mL using Human IgG1 myeloma protein for coating.	technique(s) indirect ELISA: 1:10,000
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form -

General description

Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. The abundance of the different IgG subclasses in the bloodstream varies with age, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels rise more slowly, reaching adult levels at about 10 years of age.

Immunogen

Human IgG3 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads

Application

Anti-Human IgG3 antibody, mouse monoclonal has been used in indirect ELISA and immunoprecipitation.

Biochem/physiol Actions

IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial . IgG3 deficiency has been associated with a history of recurrent infectious, leading to chronic lung disease.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

0000147967

51170302

057M4811V

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Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study.

R Jefferis et al.

Immunology letters, 10(3-4), 223-252 (1985-01-01)

Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the IgG sub-classes (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4

Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis.

Zhou, et al.

Cell Death & Disease, 14, 254-254 (2023)

IgG subclasses and allotypes: from structure to effector functions.

Gestur Vidarsson et al.

Frontiers in immunology, 5, 520-520 (2014-11-05)

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These

Contenido relacionado

Data Sheet - SAB4200759

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