Merck
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SAB4700751

Sigma-Aldrich

Monoclonal Anti-CD28 antibody produced in mouse

clone CD28.2, purified immunoglobulin, buffered aqueous solution

Synonym(s):
Anti-MFASCD28-P
NACRES:
NA.41

Nivel de calidad

100

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

antibody product type

primary antibodies

clon

CD28.2, monoclonal

formulario

buffered aqueous solution

species reactivity

human, nonhuman primates

concentración

1 mg/mL

technique(s)

FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotipo

IgG1

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

2-8°C

Gene Information

human ... CD28(940)

Descripción general

Cluster of differentiation 28 (CD 28) is a lymphocyte surface protein. In human chromosome, the gene CD28 is localized on 2q33.2. The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. HLDA V.; WS Code 5T CD28.05.

Inmunógeno

DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA

Acciones bioquímicas o fisiológicas

Cluster of differentiation 28 (CD28) acts as a costimulatory molecule for T cell activation and proliferation. CD28 might function as a tumor suppressor gene and the polymorphism is related to increased risk of breast cancer. CD28 plays a key role in allogenic responses. The level of CD28 is upregulated in CD4+ lymphocytes during acute graft rejection. Polymorphism in CD28 owing to higher frequency of CD28 molecule has impact on schizophrenia. Mutations in CD28 is associated with T cell lymphoma′s and neoplasm, leading to accelerated tumour growth. CD28 along with phosphatidylinositol 3 kinase (PI3K) regulates diverse biochemical pathways. CD28 signals to T cells and prevents anergy and apoptosis and promotes T cell proliferation and production of interleukin-2.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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