Merck
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SRP3330

Sigma-Aldrich

IL-6 from mouse

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):
HPGF, IFN-?2, B cell differentiation factor (BCDF), BSF-2
NACRES:
NA.32

origen biológico

mouse

recombinante

expressed in E. coli

ensayo

≥98% (HPLC)
≥98% (SDS-PAGE)

formulario

lyophilized

potencia

5x10^7 units/mg ED50

mol peso

21.7 kDa

envase

pkg of 10 μg

impurezas

endotoxin, tested

color

white to off-white

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

mouse ... IL6(16193)

Descripción general

Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Aplicación

IL-6 from mouse has been used to study IL-6-mediated inhibition of mouse preadipocyte differentiation.

Acciones bioquímicas o fisiológicas

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R and gp130.

Forma física

Lyophilized from 0.1% TFA

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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