T0632

Sigma-Aldrich

Sodium thioglycolate

≥96.5% (iodometric)

Sinónimos:
Thioglycolic acid sodium salt, Mercaptoacetic acid sodium salt
Fórmula lineal:
HSCH2COONa
Número de CAS:
Peso molecular:
114.10
Beilstein/REAXYS Number:
4569109
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.25

Nivel de calidad

200

ensayo

≥96.5% (iodometric)

mp

>300 °C (lit.)

temp. de almacenamiento

−20°C

SMILES string

[Na+].[O-]C(=O)CS

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

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Aplicación

Sodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Envase

25, 100, 500 g in poly bottle

Acciones bioquímicas o fisiológicas

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.
Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.

Precaución

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

pictogramas

CorrosionSkull and crossbones

Palabra de señalización

Danger

Frases de peligro

hazcat

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Met. Corr. 1 - Skin Sens. 1

storage_class_code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Alemania

WGK 1

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Certificado de origen

Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate
Rhodes DG, et al.
Vaccine, 33(44), 6011-6016 (2015)
Romina A Cutrullis et al.
Immunobiology, 222(2), 423-431 (2016-09-04)
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a key player in innate immunity. MIF has been considered critical for controlling acute infection by the protozoan Trypanosoma cruzi, but the underlying mechanisms are poorly understood. Our study aimed to...
Kim De Paepe et al.
PeerJ, 7, e6293-e6293 (2019-02-01)
Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex...
Development of Parvalbumin-Expressing Basket Terminals in Layer II of the Rat Medial Entorhinal Cortex
Berggaard N, et al.
eNeuro, 5(3) (2018)
Development of a new protocol for the isolation and quantification of Arcobacter species from poultry products
Houf K, et al.
International Journal of Food Microbiology, 71(2-3), 189-196 (2001)

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