Merck
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T5516

Sigma-Aldrich

3,3′,5-Triiodo-L-thyronine sodium salt

γ-irradiated, powder, suitable for, suitable for cell culture

Sinónimos:
Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3
Empirical Formula (Hill Notation):
C15H11I3NNaO4
Número de CAS:
Peso molecular:
672.96
Beilstein:
8179867
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

200

origen biológico

synthetic (organic)

esterilidad

γ-irradiated

ensayo

≥90% (HPLC)

formulario

powder

technique(s)

cell culture | mammalian: suitable

idoneidad

suitable for

enviado en

ambient

temp. de almacenamiento

−20°C

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

Gene Information

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Descripción general

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Aplicación

3,3′,5-Triiodo-L-thyronine sodium salt has been used:
  • as a supplement in colon organ culture media
  • to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
  • to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

Acciones bioquímicas o fisiológicas

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Forma física

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Nota de preparación

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride

Reconstitución

To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

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Certificado de origen

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Más documentos

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Medical Biochemistry, 769-769 (2001)
Irene Antolino-Lobo et al.
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Human colon tissue in organ culture: preservation of normal and neoplastic characteristics
Dame MK, et al.
In Vitro Cellular & Developmental Biology. Animal, 46(2), 114-122 (2010)

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