Merck
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T6575

Sigma-Aldrich

TOFA

≥98% (HPLC)

Synonym(s):
5-(Tetradecyloxy)-2-furoic acid
Empirical Formula (Hill Notation):
C19H32O4
CAS Number:
Molecular Weight:
324.45
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

mp

112-115 °C

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

−20°C

SMILES string

CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O

InChI

1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)

InChI key

CZRCFAOMWRAFIC-UHFFFAOYSA-N

Aplicación

TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).
TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells.

Envase

5 mg in glass bottle
25 mg in poly bottle

Acciones bioquímicas o fisiológicas

5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.
TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 μM in human breast cancer cell line MCF7).

Nota de preparación

TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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