V5754

Veratridine

≥90% (HPLC), powder

• Sinónimos: 3-Veratroylveracevine, Veracevine veratrate
• Empirical Formula (Hill Notation): C₃₆H₅₁NO₁₁
• Número de CAS: 71-62-5
• Peso molecular: 673.79
• Beilstein: 78875
• Número de EC: 200-758-4
• Número MDL: MFCD00082515
• ID de la sustancia en PubChem: 24900756
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• ensayo: ≥90% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: ethanol: 50 mg/mL
• temp. de almacenamiento: −20°C
• SMILES string: COc1ccc(cc1OC)C(=O)OC2CC[C@@]3(C)C4CCC5[C@]6(O)C[C@H](O)[C@@]7(O)C(CN8CC(C)CCC8[C@@]7(C)O)[C@]6(O)C[C@]35O[C@]24O
• InChI: 1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19?,23?,24?,25?,26?,27-,28?,30-,31+,32+,33+,34+,35-,36-/m0/s1
• InChI key: FVECELJHCSPHKY-FCSYLLAHSA-N

Descripción

Descripción general

Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.

Aplicación

Veratridine has been used:

• to record the veratridine-dependent increase in the late Na⁺ current using a HEK293 cell line stably transfected with human Na v1.5 24(4) to measure the ranolazine-induced inhibition of basal and veratridine-activated I Na late
• to assess the effects of veratridine on action potentials (APs) in hiPSC-cardiomyocyte preparations externally paced in current-clamp mode
• to study the inhibitory effects of veratridine on hERG1 current in stably transfected HEK293 cells
• to treat neuroblastoma 2-a cells to improve sensitivity for N2a assay

Envase

25, 100 mg in glass bottle

10 mg in glass insert

Acciones bioquímicas o fisiológicas

Veratridine has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals.

Opens voltage-dependent Na⁺ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

Información de seguridad

• pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330 - H315 - H319 - H335 - H361f - H373 - H412
• Consejos de prudencia: P201 - P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
• Órganos de actuación: Nervous system, Respiratory system
• Código de clase de almacenamiento: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges