Z3777

Sigma-Aldrich

ZD7288 hydrate

≥98% (HPLC)

Sinónimos:
4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride, ICI-D7288, N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine hydrochloride, ZD 7288
Empirical Formula (Hill Notation):
C15H20N4 · HCl · xH2O
Peso molecular:
292.81 (anhydrous basis)
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

DMSO: 10 mg/mL, clear

emisor

AstraZeneca

temp. de almacenamiento

2-8°C

SMILES string

O.Cl.CCN(c1ccccc1)C2=CC(=N/C)\N(C)C(C)=N2

InChI

1S/C15H20N4.ClH.H2O/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;;/h6-11H,5H2,1-4H3;1H;1H2/b16-14+;;

InChI key

NCEDDDWQLCMZQG-UPONXUSQSA-N

Aplicación

ZD7288 hydrate has been used as Ih blocker to study its effect on
neocortical tissue. It has been used as hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker to test the involvement of HCN channels in the phototransduction pathway.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.
ZD7288 can block hippocampal synaptic plasticity.

RIDADR

NONH for all modes of transport

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

The anticonvulsant lamotrigine enhances Ih in layer 2/3 neocortical pyramidal neurons of patients with pharmacoresistant epilepsy
Lehnhoff J, et al.
Neuropharmacology, 144, 58-69 (2019)
Marcin Siwiec et al.
Neuropharmacology, 177, 108248-108248 (2020-08-01)
Accumulating evidence suggests a widespread role of serotonin 5-HT7 receptors (5-HT7Rs) in the physiology of cognitive and affective processing. However, we still lack insights into 5-HT7R electrophysiology. Studies analyzing the 5-HT7R-mediated changes in CA1 pyramidal neuron activity revealed that 5-HT7R...
Cyclic-Nucleotide-and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells
Jiang Z, et al.
Cell, 175(3), 652-664 (2018)
Yingchao Xue et al.
Stem cells translational medicine, 8(2), 112-123 (2018-11-06)
Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage-specific neurons. However, current strategies mainly rely on genome-integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced pluripotent stem...
ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity
Zhang XX, et al.
Neural Regeneration Research, 11(5), 779-779 (2016)
Contenido relacionado
Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.
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