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Jean-Benoît Corcuff et al.
European journal of endocrinology, 172(4), 473-481 (2015-01-28)
Severe Cushing's syndrome elicited by ectopic ACTH syndrome (EAS) or adrenal carcinoma (ACC) can threaten life in the short term. The effectiveness of oral administration of the inhibitors of steroidogenesis ketoconazole and metyrapone in this situation is poorly described. To...
Minna U Kaikkonen et al.
Nucleic acids research, 42(20), 12570-12584 (2014-10-30)
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells...
Alexandra Ursache et al.
Physiology & behavior, 138, 266-272 (2014-12-03)
Physiological responses to threat occur through both the autonomic nervous system (ANS) and the hypothalamic pituitary adrenal (HPA) axis. Activity in these systems can be measured through salivary alpha-amylase (sAA) and salivary cortisol, respectively. Theoretical work and empirical studies have...
Daniel Berry et al.
Developmental psychology, 50(2), 514-525 (2013-06-19)
A considerable body of literature suggests that children's child-care experiences may impact adrenocortical functioning in early childhood. Yet emerging findings also suggest that the magnitude and sometimes the direction of child-care effects on development may be markedly different for children...
Q Li et al.
Oncogene, 33(20), 2589-2600 (2013-06-12)
The major goal of breast cancer prevention is to reduce the incidence of ductal carcinoma in situ (DCIS), an early stage of breast cancer. However, the biology behind DCIS formation is not well understood. It is suspected that cancer stem...
Christine M Helfer et al.
Viruses, 6(8), 3228-3249 (2014-08-21)
The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral...
Ashley J Parks et al.
Molecular pharmacology, 86(5), 593-608 (2014-08-28)
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual...
Maike Ter Wolbeek et al.
Brain, behavior, and immunity, 45, 128-138 (2014-12-03)
Neonatal glucocorticoid (GC) treatment is used to prevent bronchopulmonary dysplasia (BPD) in prematurely born babies. In the 1990s, treatment regimens with relatively high doses of dexamethasone (DEX) were common. As an alternative, hydrocortisone (HC) was used. Earlier, we compared long-term...
Filip Růžička et al.
Psychoneuroendocrinology, 52, 302-310 (2015-01-03)
Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation to the position of active stimulating contact within the...
Mario Cioce et al.
Oncotarget, 5(12), 4129-4143 (2014-07-02)
Metabolic remodeling is a hallmark of cancer progression and may affect tumor chemoresistance. Here we investigated by 1H-NMR/PCA analysis the metabolic profile of chemoresistant breast cancer cell subpopulations (ALDHbright cells) and their response to metformin, a promising anticancer metabolic modulator....
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from...
Can Lu et al.
Journal of cellular biochemistry, 115(8), 1458-1466 (2014-03-13)
Parthenolide is the main bioactive component in feverfew, a common used herbal medicine, and has been extensively studied in relation to its anti-cancer properties. However there have been very few in-depth studies of the activities of this compound at the...
Zhi-qiang Pan et al.
Molecular and cellular endocrinology, 394(1-2), 119-128 (2014-07-20)
Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid...
Gustav Schelling et al.
Annals of the New York Academy of Sciences, 1071, 46-53 (2006-08-08)
Like other humans exposed to extreme trauma, patients who have been treated in an intensive care unit (ICU) often report traumatic memories. Extremely traumatic memories from the ICU in some of these patients are associated with the development of posttraumatic...
Jackie Swartz et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 26(2), 153-160 (2015-01-27)
Infants from anthroposophic families have low cortisol levels and low risk of IgE-sensitization during first 2 years of life. Our aim was to study the impact of an anthroposophic lifestyle and cortisol levels at 6 months on allergy sensitization up to age...
Rachel Yehuda et al.
Psychoneuroendocrinology, 51, 589-597 (2014-09-13)
Prolonged exposure (PE) therapy for post-traumatic stress disorder (PTSD) in military veterans has established efficacy, but is ineffective for a substantial number of patients. PE is also associated with high dropout rates. We hypothesized that hydrocortisone augmentation would enhance symptom...
Jun-Jie Guan et al.
Tissue engineering. Part A, 20(13-14), 1794-1806 (2014-01-07)
Stem cells in human urine have gained attention in recent years; however, urine-derived stem cells (USCs) are far from being well elucidated. In this study, we compared the biological characteristics of USCs with adipose-derived stem cells (ASCs) and investigated whether...
Christina Maria Anna Pia Schuh et al.
Cytotherapy, 16(12), 1666-1678 (2014-09-02)
Adipose-derived progenitor/stem cells (ASCs) are discussed as a promising candidate for various tissue engineering approaches. However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity as...
Susumu Tadokoro et al.
PloS one, 10(3), e0121242-e0121242 (2015-03-24)
Leptin, a 16 kDa anti-obesity hormone, exhibits various physiological properties. Interestingly, skin wound healing was proven to delay in leptin-deficient ob/ob mice. However, little is known on the mechanisms of this phenomenon. In this study, we attempted to elucidate a...
Fernand Labrie
The Journal of steroid biochemistry and molecular biology, 145, 133-138 (2014-06-14)
Following the arrest of estradiol secretion by the ovaries at menopause, all estrogens and all androgens in postmenopausal women are made locally in peripheral target tissues according to the physiological mechanisms of intracrinology. The locally made sex steroids exert their...
Yuanyuan Liu et al.
Cell biology international, 38(11), 1304-1310 (2014-06-20)
Radiotherapy has been focused mainly on killing cancer cells, and little attention has been paid to the process supporting tumor growth and metastasis, including the process of angiogenesis. To investigate the effects of carbon-ion irradiation on angiogenesis in lung cancer...
Reversal of non-suppression of cortisol levels in a patient with refractory depression receiving ketamine.
Robert Ostroff et al.
The American journal of psychiatry, 172(1), 95-96 (2015-01-02)
Daniel J O Roche et al.
Psychoneuroendocrinology, 52, 59-71 (2014-12-03)
Women often exhibit larger hormonal and subjective responses to opioid receptor antagonists than men, but the biological mechanisms mediating this effect remain unclear. Among women, fluctuations in estradiol (E2) and progesterone (P4) across the menstrual cycle (MC) affect the endogenous...
Cheng Huan et al.
Bio-medical materials and engineering, 24(6), 3439-3446 (2014-09-18)
The purpose of this study was to assess gender-related distinction in the performance of Cushing's disease (CD) regarding clinical features, radiological findings, neurological and endocrine status, surgical outcome, and quality of life in Han Chinese. A retrospective study was conducted...
Gokhan Tazegul et al.
Magnetic resonance imaging, 33(1), 180-183 (2014-09-01)
To evaluate the effectivity of a combined intervention of information and communication to reduce magnetic resonance imaging (MRI) anxiety using prolactin and cortisol as biochemical markers and State Trait Anxiety Inventory (STAI). This study is a randomized prospective research. Sample...
Yanhui Han et al.
The Journal of parasitology, 100(4), 463-469 (2014-03-19)
Schistosomes infect around 280 million people worldwide. The worms survive in the veins of the final host, where thioredoxin glutathione reductase (TGR) activity helps the parasites to survive in the aerobic environment. In the present study, we synthesized 4 small...
Shiri Shahmoon et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E326-E334 (2014-06-19)
Klotho is a transmembranal protein highly expressed in the kidneys, choroid plexus, and anterior pituitary. Klotho can also be cleaved and shed and acts as a circulating hormone. Klotho-deficient mice (kl/kl mice) develop a phenotype resembling early aging. Several lines...
Peter Vrtačnik et al.
Analytical biochemistry, 463, 38-44 (2014-07-02)
The accuracy of techniques such as microarrays, reverse transcription polymerase chain reaction, and whole transcriptome shotgun sequencing is critically dependent on RNA quality. We have repeatedly observed extensive RNA degradation following trypsinization, a routine procedure used to dissociate adherent tissue...
Nassima Belaidi et al.
Clinical biochemistry, 48(1-2), 89-92 (2014-12-03)
To extend knowledge about the clinical performances of a new chemiluminescent immunoassay (CLIA) for aldosterone set up in available analysers. We compared the results of a RIA assay to those of a CLIA assay in 198 serum and 80 urine...
Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise.
Peake JM, Tan SJ, Markworth JF, et al.
American Journal of Physiology. Endocrinology and Metabolism, 307(7), E539-E552 (2014)
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