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" within Papeles
Yves Reznik
Presse medicale (Paris, France : 1983), 43(4 Pt 1), 438-443 (2014-03-19)
Quality of life remains altered in the adrenal insufficient patient treated by hydrocortisone and fludrocortisone. Due to its pharmacokinetics properties, hydrocortisone requires 2 to 3 daily doses - including a morning intake of 2/3 or half of the daily dose respectively -
Stefan Kempke et al.
Psychoneuroendocrinology, 52, 14-21 (2014-12-03)
There is a paucity of studies that have investigated the assumption that early childhood trauma is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction in Chronic Fatigue Syndrome (CFS). The current study is the first to simultaneously investigate relationships among early childhood
Rebecca L Dahlin et al.
Annals of biomedical engineering, 42(7), 1381-1390 (2013-07-12)
In this study, we investigated the effect of flow perfusion culture on the mineralization of co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). Osteogenically precultured hMSCs were seeded onto electrospun scaffolds in monoculture or
Ye Zhao et al.
BMC cell biology, 15, 40-40 (2014-12-01)
Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated primary endothelial cells due to the unavailability of endothelial cell
Peter Vrtačnik et al.
Analytical biochemistry, 463, 38-44 (2014-07-02)
The accuracy of techniques such as microarrays, reverse transcription polymerase chain reaction, and whole transcriptome shotgun sequencing is critically dependent on RNA quality. We have repeatedly observed extensive RNA degradation following trypsinization, a routine procedure used to dissociate adherent tissue
Jason A Campagna et al.
Anesthesiology, 121(6), 1203-1216 (2014-08-30)
Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation "soft" (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM's pharmacology in beagle dogs in preparation for potential first in human phase 1 clinical trials.
Jennifer L Bolton et al.
PLoS genetics, 10(7), e1004474-e1004474 (2014-07-11)
Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has
Iva Kulic et al.
The Journal of experimental medicine, 212(1), 37-52 (2014-12-17)
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ
E H Mojumdar et al.
Biochimica et biophysica acta, 1838(10), 2473-2483 (2014-05-31)
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present
Jaap J A J van der Velden et al.
Experimental dermatology, 24(4), 285-289 (2015-02-04)
Acral peeling skin syndrome (APSS, MIM #609796) is a rare autosomal recessive disorder characterized by superficial exfoliation and blistering of the volar and dorsal aspects of hands and feet. The level of separation is at the junction of the stratum
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from
Can Lu et al.
Journal of cellular biochemistry, 115(8), 1458-1466 (2014-03-13)
Parthenolide is the main bioactive component in feverfew, a common used herbal medicine, and has been extensively studied in relation to its anti-cancer properties. However there have been very few in-depth studies of the activities of this compound at the
Jean-Benoît Corcuff et al.
European journal of endocrinology, 172(4), 473-481 (2015-01-28)
Severe Cushing's syndrome elicited by ectopic ACTH syndrome (EAS) or adrenal carcinoma (ACC) can threaten life in the short term. The effectiveness of oral administration of the inhibitors of steroidogenesis ketoconazole and metyrapone in this situation is poorly described. To
Yanhui Han et al.
The Journal of parasitology, 100(4), 463-469 (2014-03-19)
Schistosomes infect around 280 million people worldwide. The worms survive in the veins of the final host, where thioredoxin glutathione reductase (TGR) activity helps the parasites to survive in the aerobic environment. In the present study, we synthesized 4 small
Shiri Shahmoon et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E326-E334 (2014-06-19)
Klotho is a transmembranal protein highly expressed in the kidneys, choroid plexus, and anterior pituitary. Klotho can also be cleaved and shed and acts as a circulating hormone. Klotho-deficient mice (kl/kl mice) develop a phenotype resembling early aging. Several lines
Andrea L Glenn et al.
Psychoneuroendocrinology, 54, 14-23 (2015-02-11)
Recent investigations of the psychobiology of stress in antisocial youth have benefited from a multi-system measurement model. The inclusion of salivary alpha-amylase (sAA), a surrogate marker of autonomic/sympathetic nervous system (ANS) activity, in addition to salivary cortisol, a biomarker of
Cheng Huan et al.
Bio-medical materials and engineering, 24(6), 3439-3446 (2014-09-18)
The purpose of this study was to assess gender-related distinction in the performance of Cushing's disease (CD) regarding clinical features, radiological findings, neurological and endocrine status, surgical outcome, and quality of life in Han Chinese. A retrospective study was conducted
Gokhan Tazegul et al.
Magnetic resonance imaging, 33(1), 180-183 (2014-09-01)
To evaluate the effectivity of a combined intervention of information and communication to reduce magnetic resonance imaging (MRI) anxiety using prolactin and cortisol as biochemical markers and State Trait Anxiety Inventory (STAI). This study is a randomized prospective research. Sample
Christian C Lachaud et al.
Investigative ophthalmology & visual science, 55(9), 5967-5978 (2014-08-21)
To evaluate whether mouse adipose tissue mesothelial cells (ATMCs) share morphologic and biochemical characteristics with mouse corneal endothelial cells (CECs) and to evaluate their capacity to adhere to the decellularized basal membrane of human anterior lens capsules (HALCs) as a
Mirko Peitzsch et al.
The Journal of steroid biochemistry and molecular biology, 145, 75-84 (2014-10-15)
Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/MS). Adrenal venous (AV) measurements of aldosterone and cortisol are a standard practice in the
Sian Warren et al.
International journal of STD & AIDS, 25(14), 1044-1046 (2014-03-29)
This case describes a young white British man with a one-year history of recurrent genital ulceration managed by the GP. Initially this was thought to be a drug reaction; however, presentation at our genitourinary medicine clinic and onward review with
Wim F P M Van den Hof et al.
Toxicology, 324, 18-26 (2014-07-23)
The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better pre-clinical toxicity tests are needed. In order to bypass animal models for toxicity screening, we exposed primary mouse hepatocytes
G Karagüzel et al.
Minerva endocrinologica, 39(4), 235-243 (2014-07-30)
Cortisol is the major glucocorticoid synthesized by the adrenal cortex and its secretion is under the control of hypothalamic-pituitary axis. There is an increase in corticotrophin-releasing hormone and corticotrophin secretion and a decrease in the negative-feedback effect during critical illness.
Camilla Brorsson et al.
Injury, 45(8), 1149-1155 (2014-07-01)
The adrenal response in critically ill patients, including trauma victims, has been debated over the last decade. The aim of this study was to assess the early adrenal response after trauma. Prospective, observational study of 50 trauma patients admitted to
Kyriakie Sarafoglou et al.
The Journal of pediatrics, 164(5), 1141-1146 (2014-02-25)
To estimate the impact of the average daily dose of hydrocortisone (HC) on the amount of growth attained in children with congenital adrenal hyperplasia (CAH). The effect of glucocorticoid therapy on adult height (AH) in children with CAH has yet
Ibeth Guevara-Lora et al.
Journal of cellular biochemistry, 115(11), 1985-1995 (2014-06-14)
Adhesion of leukocytes to vascular endothelium in response to proinflammatory mediators is an important component of the overall inflammatory reaction. In the current work, we used a retinoic acid-differentiated human promonocytic cell line, U937 and a human microvascular endothelial cell
Mathilde Couteaudier et al.
Stem cell research, 14(2), 224-237 (2015-02-24)
A common challenge in avian cell biology is the generation of differentiated cell-lines, especially in the keratinocyte lineage. Only a few avian cell-lines are available and very few of them show an interesting differentiation profile. During the last decade, mammalian
Hiroaki Sugiyama et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(8), 1544-1555 (2014-04-29)
Tissue engineering has become an essential tool in the development of regenerative medicine. We have developed cell sheet-based techniques for use in regenerative medicine that have already been successfully used in clinical applications. Native corneal epithelium is produced from limbal
Renfu Quan et al.
Stem cell research & therapy, 5(5), 118-118 (2014-10-22)
In the field of skin tissue engineering, gelatin-chondroitin-6-sulfate-hyaluronic acid (Gel-C6S-HA) stents are a suitable bio skin substitute. The purpose was to investigate the effect of genetically-modified hair follicle stem cells (HFSCs), combined with Gel-C6S-HA scaffolds, on the vascularization of tissue-engineered
Hisanobu Ota et al.
PloS one, 10(4), e0123733-e0123733 (2015-04-16)
Relationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of
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