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Overexpression of Functional SLC6A3 in Clear Cell Renal Cell Carcinoma.
Jennifer Hansson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(8), 2105-2115 (2016-09-25)
Adriano Lama et al.
British journal of pharmacology, 178(4), 845-859 (2020-04-30)
High-fat diet (HFD)-induced obesity is accompanied by metabolic and neurochemical changes that have been associated with depression. Recent studies indicate that palmitoylethanolamide (PEA) exerts metabolic effects and holds neuroprotective potential. However, studies on HFD exposure in mice which investigate the
D Beeler et al.
The Journal of biological chemistry, 254(8), 2902-2913 (1979-04-25)
Preparations of low molecular weight porcine heparin with an average specific anticoagulant activity of 94 units/mg were fractionated into "active" and "relatively inactive" forms of the mucopolysaccharide of approximately 6000 daltons each. The active fraction was further subdivided into various
Nada M S Al-Saffar et al.
British journal of cancer, 119(9), 1118-1128 (2018-11-01)
AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling would result in metabolic changes that could potentially be
Ronit Abir et al.
Journal of assisted reproduction and genetics, 37(9), 2105-2117 (2020-07-28)
To investigate if human ovarian grafting with pure virgin human recombinant collagen type-1 from bioengineered plant lines (CollPlant™) or small intestine submucosa (SIS) yields better implantation results for human ovarian tissue and which method benefits more when combined with the
P Schneider et al.
The Journal of experimental medicine, 189(11), 1747-1756 (1999-06-08)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF
Mary C Farach-Carson et al.
Matrix biology : journal of the International Society for Matrix Biology, 27(2), 150-160 (2007-11-13)
Perlecan/HSPG2 is a large, multi-domain, multifunctional heparan sulfate proteoglycan with a wide tissue distribution. With the exception of its unique domain I, each of perlecan's other four domains shares sequence similarity to other protein families including low density lipoprotein (LDL)
Mechanism of the anticoagulant action of heparin.
I Björk et al.
Molecular and cellular biochemistry, 48(3), 161-182 (1982-10-29)
Sarah Burl et al.
PloS one, 6(4), e18185-e18185 (2011-05-03)
The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations to inducing effective immunity
L B Schwartz et al.
The Journal of biological chemistry, 261(16), 7372-7379 (1986-06-05)
Tryptase was shown to be stabilized as an enzymatically active tetramer by association with heparin and dissociated to inactive monomers in the absence of heparin at 37 degrees C in physiologic buffer and in plasma. There was a 50% loss
Circulation, 55(2), 423-426A-423-426A (1977-02-01)
Presently available data indicate that low-dose heparin will significantly diminish postoperative deep venous thrombosis and pulmonary embolism in patients over the age of 40 subjected to major elective abdomino-thoracic surgery. The schedule is 5,000 USP units of heparin subcutaneously beginning
Takahisa Miyamoto et al.
Journal of microbiological methods, 137, 6-13 (2017-03-30)
Catechins are major polyphenolic compounds of green tea. To investigate mechanism for antibacterial action of catechins, 11 monoclonal antibodies (MAbs) were raised against a 3-succinyl-epicatechin (EC)-keyhole limpet hemocyanin (KLH) conjugate. Amino acid sequences of variable regions determined for MAbs b-1058
Maria Lehmann et al.
Journal of virology, 88(15), 8713-8717 (2014-05-16)
The N terminus of arenavirus L protein contains an endonuclease presumably involved in "cap snatching." Here, we employed the Lassa virus replicon system to map other L protein sites that might be involved in this mechanism. Residues Phe-1979, Arg-2018, Phe-2071
Ziad A Memish et al.
Lancet (London, England), 395(10229), 1063-1077 (2020-03-08)
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April
K Suzuki et al.
The Journal of biological chemistry, 262(2), 611-616 (1987-01-15)
A cDNA library in lambda-phage lambda gt11 containing DNA inserts prepared from human liver mRNA was screened with monoclonal antibodies to human protein C inhibitor. Six positive clones were isolated from 6 X 10(6) phages and plaque purified. The cDNA
Yu Wu et al.
Reproductive biology and endocrinology : RB&E, 12, 96-96 (2014-10-10)
The goal of this study was to assess the association between endometrial thickness on the chorionic gonadotropin (hCG) day and in vitro fertilization and embryo transfer (IVF-ET) outcome in normal responders after GnRH antagonist administration. A retrospective cohort study was
Ilona Szivak et al.
The Journal of biological chemistry, 281(24), 16740-16749 (2006-04-12)
Anti-phosphopeptide antibodies were raised against phosphatidylinositol 4-kinase (PI4K92) phosphorylation sites (Suer, S., Sickmann, A., Meyer, H. E., Herberg, F. W., and Heilmeyer, L. M. Jr. (2001) Eur. J. Biochem. 268, 2099-2106). Characterization proved three of them (anti-pSer-294, anti-pSer-496, and anti-pThr-504
Philip M Roper et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 34(12), 2106-2115 (2016-03-22)
The process of fracture healing is complex, and poor or incomplete healing remains a significant health problem. Proper fracture healing relies upon resident mesenchymal stem cell (MSC) differentiation into chondrocytes and osteoblasts, which are necessary for callus formation and ossification.
L R Finger et al.
Gene, 197(1-2), 177-187 (1997-10-23)
We report the complete cDNA sequence and the genomic structure of the human PD-1 homologue. An analysis of the expression pattern of the human PD-1 gene (hPD-1) and the murine PD-1 gene (mPD-1) in developing bone marrow B-lineage cells was
Chun-Ge Zhang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(7), 2093-2106 (2016-07-14)
P-glycoprotein (P-gp) plays an importantrole in multidrug resistance (MDR), proved to be one of the major obstacles in cancer chemotherapy. Cationic polymers could specifically deliver siRNA to tumor cells and thus reverse MDR by the downregulation of P-gp. In this
R E Leube
Differentiation; research in biological diversity, 56(3), 163-171 (1994-05-01)
The integral membrane protein synaptophysin is one of the major polypeptide components of the small, electron-translucent, transmitter-containing vesicles in neurons and of similar vesicles in neuroendocrine (NE) cells. In an attempt to identify synaptophysin-related molecules, such as synaptoporin, it was
Adi Vaknin-Dembinsky et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 16(12), 1453-1457 (2010-10-12)
Anti-aquaporin-4 antibodies are believed to have a central pathogenetic role in neuromyelitis optica (NMO). B-cell activating factor (BAFF) is one of the crucial factors that determines the fate and survival of B cells and may play a role in induction
Helga Westerlind et al.
European journal of human genetics : EJHG, 23(5), 688-692 (2014-08-28)
In an attempt to map chromosomal regions carrying rare gene variants contributing to the risk of multiple sclerosis (MS), we identified segments shared identical-by-descent (IBD) using the software BEAGLE 4.0's refined IBD analysis. IBD mapping aims at identifying segments inherited
Audrey Deeken-Draisey et al.
Human pathology, 82, 140-148 (2018-08-04)
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of thyroid cancer. A single-institution thyroid cancer cohort of ATC was identified within the last 10 years at our institution. Retrospective analysis revealed that the frequency of ATC was 0.5% (11/2106
Guo-Rui Ruan et al.
Zhongguo shi yan xue ye xue za zhi, 15(3), 462-465 (2007-07-04)
The objective of this study was to estimate a novel apoptosis-promoting molecule PDCD5 expression in the bone marrow cells from adult acute myeloid leukemia (AML) for investigation of its significance in the pathogenesis of AML. Flow cytometry assay was used
Samir N Kelada et al.
Pharmacogenetics and genomics, 15(9), 659-668 (2005-07-26)
The dopamine transporter (DAT) plays a critical role in dopaminergic neurotransmission and is also the major site of action for some drugs of abuse. The coding region of the DAT gene, SLC6A3, is well conserved, but non-coding regions are more
Jemma C Hopewell et al.
Circulation. Cardiovascular genetics, 4(1), 68-73 (2011-01-22)
Genetic studies have identified 2 single-nucleotide polymorphisms (SNPs) at the LPA locus (rs3798220 and rs10455872) that are strongly and independently related to lipoprotein(a) levels and to coronary disease risk, but their relevance for other atherothrombotic disease is uncertain. These 2
Zhilan Hu et al.
Biotechnology and bioengineering, 113(10), 2100-2106 (2016-03-19)
Heterogeneity of C-terminal lysine levels often observed in therapeutic monoclonal antibodies is believed to result from the proteolysis by endogenous carboxypeptidase(s) during cell culture production. Identifying the responsible carboxypeptidase(s) for C-terminal lysine cleavage in CHO cells would provide valuable insights
C A Handford et al.
Brain research. Molecular brain research, 35(1-2), 211-219 (1996-01-01)
The inhibitory glycine receptor (GlyR) is a pentameric receptor comprised of alpha and beta subunits, of which the beta subunit has not been characterised in humans. A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open
S A Godambe et al.
Molecular and cellular biology, 15(1), 112-119 (1995-01-01)
Regulatory elements important for transcription of the murine interleukin-1 beta (IL-1 beta) gene lie within a DNase I-hypersensitive region located > 2,000 bp upstream from the transcription start site. We have identified within this region a novel positive regulatory element
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