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216763

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Wenwen Wang et al.
Toxicology and applied pharmacology, 313, 195-203 (2016-10-26)
Triptolide (TP), a diterpene triepoxide, is a major active component of Tripterygium wilfordii extracts, which are prepared as tablets and has been used clinically for the treatment of inflammation and autoimmune disorders. However, TP's therapeutic potential is limited by severe...
Kuo-Feng Huang et al.
Free radical biology & medicine, 141, 220-232 (2019-06-21)
Ultraviolet (UV) irradiation causes cellular oxidative stress. Under redox imbalance, Keap1-dependent Nrf2 degradation is minimal. In this study, we examined the role of Ca2+ in Nrf2 homeostasis after UVB irradiation using human dermal fibroblasts. UVB irradiation stimulates 12-lipoxygenase and the...
Siyao Li et al.
Archives of toxicology, 93(9), 2673-2687 (2019-08-29)
Increasing evidence indicates that developmental exposure to nonylphenol (NP) causes damage to the central nervous system (CNS). As the most unique and primary component of neuron, axon is an essential structure for the CNS function. Here, we investigated whether developmental...
K M E Andersson et al.
Journal of leukocyte biology, 97(1), 135-145 (2014-11-09)
Survivin is a proto-oncogene that regulates cell division and apoptosis. It is a molecular marker of cancer. Recently, survivin has emerged as a feature of RA, associated with severe joint damage and poor treatment response. The present study examined if...
Dibyendu Das et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(4), 753-760 (2015-01-13)
The interaction of proteins with endotoxins has divergent effects on lipopolysaccharide (LPS)-induced responses, which serve as a basis for many clinical and therapeutic applications. It is, therefore, important to understand these interactions from both theoretical and practical points of view....
Dunja Aksentijević et al.
PloS one, 9(10), e109021-e109021 (2014-10-02)
Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the cardioprotective effect of creatine in...
Sachin Kumar et al.
ACS applied materials & interfaces, 7(5), 3237-3252 (2015-01-15)
Toward designing the next generation of resorbable biomaterials for orthopedic applications, we studied poly(ε-caprolactone) (PCL) composites containing graphene. The role, if any, of the functionalization of graphene on mechanical properties, stem cell response, and biofilm formation was systematically evaluated. PCL...
Jingjing Liu et al.
Chemical research in toxicology, 28(3), 394-400 (2014-10-18)
Carcinogenic formaldehyde is produced by endogenous protein oxidation and various exogenous sources. With formaldehyde being both ubiquitous in the ambient environment and one of the most common reactive carbonyls produced from endogenous metabolism, quantifying formaldehyde exposure is an essential step...
Shaun Martin et al.
Journal of cellular biochemistry, 116(3), 438-449 (2014-10-23)
Glucose-regulated protein 78 (GRP78) is a stress sensor which interacts with unfolded protein response (UPR) activators in the endoplasmic reticulum (ER). The aim of this study was to test the hypothesis that GRP78 has distinct functional roles in mediating the...
Sadaf S Arain et al.
Biological trace element research, 168(2), 287-295 (2015-05-16)
It has been extensively reported that chewing of smokeless tobacco (SLT) can lead to cancers of oral cavity. In present study, the relationship between arsenic (As) exposure via chewing/inhaling different SLT products in oral cancer patients have or/not consumed SLT...
Martina C Herwig et al.
Experimental eye research, 127, 243-251 (2014-08-20)
During human ocular development, expression of proteins varies in different maturation stages. This study aims to characterize structures in human fetal eyes stained by the lymphatic marker podoplanin (D2-40) with emphasis on the stage of maturation and the presence of...
Delfo D'Alessandro et al.
Biomedical materials (Bristol, England), 9(4), 045007-045007 (2014-07-17)
In this study, we performed a complete histologic analysis of constructs based on large diameter ( >100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding....
Tatiana Siqueira Gonçalves et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 762, 1-8 (2014-02-06)
Stainless steel bands, with or without silver soldered joints, are routinely used in orthodontics. However, little is known about the toxic biological effects of these appliances. The aims of this study were to evaluate the cytotoxic, cytostatic, genotoxic and DNA...
A Verma et al.
Chemosphere, 109, 7-13 (2014-05-31)
The investigation presents the observations on the use of cement beads for the immobilization of TiO2 for the degradation of herbicide isoproturon. The immobilized system was effective in degrading and mineralizing the herbicide for continuous thirty cycles without losing its...
A Sharma et al.
Leukemia, 29(1), 157-168 (2014-06-25)
Myeloid differentiation is blocked in acute myeloid leukemia (AML), but the molecular mechanisms are not well characterized. Meningioma 1 (MN1) is overexpressed in AML patients and confers resistance to all-trans retinoic acid-induced differentiation. To understand the role of MN1 as...
Muhammad Ali et al.
Molecular and cellular biochemistry, 410(1-2), 267-279 (2015-09-12)
Type 1 diabetes mellitus (DM) is a strong risk factor for the development of diabetic cardiomyopathy (DCM) which is the leading cause of morbidity and mortality in the type 1 diabetic patients. Stem cells may act as a therapeutic agent...
Manuela Zavatti et al.
Life sciences, 121, 174-183 (2014-12-03)
This study aims to evaluate the bone regeneration in a rat calvarias critical size bone defect treated with a construct consisting of collagen type I and human amniotic fluid stem cells (AFSCs) after oral administration of phytoestrogen ferutinin. In 12...
Katrin Schlegelmilch et al.
Gene, 551(2), 243-254 (2014-09-10)
WNT-induced secreted protein 1 (WISP1/CCN4), a member of the CCN protein family, acts as a downstream factor of the canonical WNT signaling pathway. Its expression is known to affect proliferation and differentiation of human mesenchymal stromal cells (hMSCs), which are...
Carmine Pasquale Cerrato et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4589-4599 (2015-07-22)
Cell-penetrating peptides (CPPs) are short, nontoxic peptides with cationic and/or amphipathic properties able to cross the cellular membrane. CPPs are used for the delivery of a wide variety of cargoes, such as proteins, oligonucleotides, and therapeutic molecules. The aim of...
Koji Nonaka et al.
Acta physiologica Hungarica, 101(4), 421-428 (2014-09-10)
We investigated muscle atrophy, major antioxidant enzymes and lipid peroxidation in the extensor digitorum longus (EDL, predominantly fast fibers) and soleus (predominantly slow fibers) muscle of streptozotocin-diabetic rats. Female Wistar rats were divided into a control (n = 5) and...
Ivonne Loeffler et al.
American journal of physiology. Renal physiology, 308(6), F511-F521 (2015-01-01)
Acute kidney injury is a common complication of critically ill patients and may occur as a result of various factors and coexisting previous illnesses. Some pathophysiological responses seen in critical illness can be similar to the human physiological response to...
Andrea Masotti et al.
Aging, 6(12), 1094-1108 (2015-01-09)
Reprogramming of human fibroblasts into induced pluripotent stem cells (iPSCs) leads to mitochondrial rejuvenation, making iPSCs a candidate model to study the mitochondrial biology during stemness and differentiation. At present, it is generally accepted that iPSCs can be maintained and...
Daewoo Suh et al.
Nature communications, 11(1), 2252-2252 (2020-05-10)
Healable conductive materials have received considerable attention. However, their practical applications are impeded by low electrical conductivity and irreversible degradation after breaking/healing cycles. Here we report a highly conductive completely reversible electron tunneling-assisted percolation network of silver nanosatellite particles for...
Hanieh Mianehrow et al.
International journal of pharmaceutics, 484(1-2), 276-282 (2015-03-05)
Stabilization of graphene oxide (GO) in physiological solution is performed using hydroxyethyl cellulose (HEC) to make the resultant nanohybrid suitable for targeted drug delivery purposes. Short and long term stability of GO suspensions with different ionic strengths were assessed using...
Shuai Yuan et al.
Molecular and cellular biology, 34(19), 3630-3641 (2014-07-23)
Methylation is a prevalent posttranscriptional modification of RNAs. However, whether mammalian microRNAs are methylated is unknown. Here, we show that the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo. Methylation...
Dan Wang et al.
Oncotarget, 5(21), 10803-10815 (2014-10-11)
Oct-4 and Nanog in regulating the epithelial-mesenchymal transition (EMT) and metastasis of breast cancer has not been clarified. We found that both Oct-4 and Nanog expression were significantly associated with tumor pathology and poor prognosis in 126 breast cancer patients....
Montana Upton et al.
Biochemical pharmacology, 97(4), 558-565 (2015-06-27)
Neuronal nicotinic acetylcholine receptors (nAChRs) are the primary binding sites for nicotine within the brain. Using alpha(α)2 nAChR subunit-null mutant mice, the current study evaluates whether the absence of this gene product during mecamylamine-precipitated nicotine withdrawal eliminates neuronal activity within...
Natalie Kelner et al.
Head & neck, 37(4), 479-486 (2014-03-29)
The presence of regional lymph node metastasis has an important impact on clinical management and prognostication of patients with oral tongue squamous cell carcinoma (SCC). Approximately 30% to 50% of patients with oral tongue SCC have regional metastasis at diagnosis...
C A Cordeiro et al.
Biosensors & bioelectronics, 67, 677-686 (2014-12-03)
Enzyme-based amperometric biosensors are widely used for monitoring key biomarkers. In experimental neuroscience there is a growing interest in in vivo continuous and simultaneous monitoring of metabolism-related biomarkers, like glucose, lactate and pyruvate. The use of multiplex biosensors will provide...
Liang Li et al.
BMC plant biology, 14, 381-381 (2014-12-31)
Recently we showed that de novo expression of a turtle riboflavin-binding protein (RfBP) in transgenic Arabidopsis increased H2O2 concentrations inside leaf cells, enhanced the expression of floral regulatory gene FD and floral meristem identity gene AP1 at the shoot apex...
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