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Shengchen Lin et al.
Cell reports, 28(11), 2824-2836 (2019-09-12)
The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood. Here, we report that fascin, an actin-bundling protein, promotes lung cancer metastatic colonization by augmenting
Haoyue Zhang et al.
Clinical chemistry, 55(3), 527-532 (2009-02-03)
The isotope-labeled intravenous glucose tolerance test (IVGTT) combined with computer modeling is widely used to derive parameters related to glucose metabolism in vivo. Most of these methods involve use of either (2)H(2)-labeled or (13)C(1)-labeled D-glucose as a tracer with GC-MS
Wen-Chih Lee et al.
Cell reports, 32(10), 108108-108108 (2020-09-10)
The metabolic program of osteoblasts, the chief bone-making cells, remains incompletely understood. Here in murine calvarial cells, we establish that osteoblast differentiation under aerobic conditions is coupled with a marked increase in glucose consumption and lactate production but reduced oxygen
Manabu Kodama et al.
Nature communications, 11(1), 1320-1320 (2020-03-19)
Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Houles T, et al.
Cancer research, canres-ca2215 (2018)
Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB
Martinez-Lumbreras S, et al.
Structure, 26(4), 640-648 (2018)
Kyle L Fulghum et al.
Journal of molecular and cellular cardiology, 162, 32-42 (2021-09-07)
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the fate of glucose-derived carbon in murine
Andreas Keymer et al.
Bio-protocol, 8(7), e2786-e2786 (2018-04-05)
Lipid transfer from host plants to arbuscular mycorrhiza fungi was hypothesized for several years because sequenced arbuscular mycorrhiza fungal genomes lack genes encoding cytosolic fatty acid synthase ( Wewer et al., 2014 ; Rich et al., 2017 ). It was
Riccardo M Betto et al.
Nature genetics, 53(2), 215-229 (2021-02-03)
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF-Stat3 signaling induces genomic hypomethylation via metabolic reconfiguration. Stat3-/- ESCs show decreased α-ketoglutarate production
Daniel L Sun et al.
RSC medicinal chemistry, 11(3), 392-410 (2021-01-23)
A potent class of isoquinoline-based α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) compounds has been rediscovered; based upon this scaffold, three series of antiproliferative agents were synthesized through iterative rounds of methylation and fluorination modifications, with anticancer activities being potentiated by physiologically relevant
Toumy Guettouche et al.
BMC biochemistry, 6, 4-4 (2005-03-12)
Heat shock factor (HSF/HSF1) not only is the transcription factor primarily responsible for the transcriptional response of cells to physical and chemical stress but also coregulates other important signaling pathways. The factor mediates the stress-induced expression of heat shock or
1alpha, 25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase
Wilmanski T, et al.
The Journal of Nutritional Biochemistry, 40, 194-200 (2017)
Stefi V Benjamin et al.
Biomolecular NMR assignments, 14(1), 151-155 (2020-02-29)
Immunoglobulin E (IgE) plays a central role in allergic reactions. IgE is a dynamic molecule that is capable of undergoing large conformational changes. X-ray crystal structures of the Fc region of IgE in complex with various ligands have shown that
William J Quinn et al.
Cell reports, 33(11), 108500-108500 (2020-12-17)
Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that nicotinamide adenine dinucleotide (NAD+), which is reduced to NADH
Frank Malz et al.
Carbohydrate research, 342(1), 65-70 (2006-12-06)
Double Quantum (DQ) NMR, which utilizes the magnetic dipole interaction between the (13)C atoms, was used for the complete assignment of the (13)C NMR resonances to the corresponding carbon ring positions for the monoclinic and triclinic allomorphs of methyl 4'-O-methyl-beta-D-cellobioside-(13)C(12)(1-(13)C(12))
Proceedings: Teratogenic actions of C13-glucose on the early development of the mouse embryo.
H Spielman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 287 Suppl, R86-R86 (1975-01-01)
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Jones, et al.
Cell Stem Cell, 27, 748-764 (2021)
Y Oda et al.
Biochemistry, 33(17), 5275-5284 (1994-05-03)
All of the individual carboxyl groups (the side-chain carboxyl groups of Asp and Glu, and the C-terminal alpha-carboxyl group) in Escherichia coli ribonuclease HI, which is an enzyme that cleaves the RNA strand of a RNA/DNA hybrid, were pH-titrated, and
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Houles T, et al.
Cancer research, canres-ca2215 (2018)
M M Zhou et al.
Biochemistry, 33(17), 5221-5229 (1994-05-03)
Phosphotyrosyl protein phosphatases play an important role in mediating cellular signal transduction; yet three-dimensional structures of this important class of proteins have not been reported. We present the sequence-specific 1H, 13C, and 15N backbone assignments for the low molecular weight
Min Yuan et al.
Nature protocols, 14(2), 313-330 (2019-01-27)
Targeted tandem mass spectrometry (LC-MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily fluids and tissues. Here, we present a protocol for analysing incorporation of the non-radioactive stable isotopes carbon-13 (13C) and
Zoran Dinev et al.
Carbohydrate research, 341(10), 1743-1747 (2006-04-11)
A simple gram-scale synthesis of uridine diphospho(13C6)glucose is presented from D-(13C6)glucose. The critical step uses a 1H-tetrazole-catalyzed coupling of 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine diphospho(13C6)glucose was used in the structural identification of (1-->3)-beta-D-glucan from Lolium multiflorum.
Rostislav Kuskovsky et al.
Analytical biochemistry, 568, 65-72 (2019-01-04)
Quantification of cellular deoxyribonucleoside mono- (dNMP), di- (dNDP), triphosphates (dNTPs) and related nucleoside metabolites are difficult due to their physiochemical properties and widely varying abundance. Involvement of dNTP metabolism in cellular processes including senescence and pathophysiological processes including cancer and
Zdenka Bartosova et al.
Metabolites, 11(3) (2021-03-07)
Thraustochytrids are marine heterotrophic microorganisms known for their potential to accumulate docosahexaenoic acid (DHA)-enriched lipids. There have been many attempts to improve thraustochytrid DHA bioprocesses, especially through traditional optimization of cultivation and media conditions. Nevertheless, thraustochytrid-based bioprocesses are still not
Yiliang Wei et al.
Cancer discovery (2021-09-18)
An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a dependency in
Katia Aquilano et al.
Redox biology, 36, 101633-101633 (2020-08-31)
Low-protein/high-carbohydrate (LPHC) diet has been suggested to promote metabolic health and longevity in adult humans and animal models. However, the complex molecular underpinnings of how LPHC diet leads to metabolic benefits remain elusive. Through a multi-layered approach, here we observed
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Houles T, et al.
Cancer Research, canres-ca2215 (2018)
Metabolic profiling reveals a coordinated response of isolated lamb's (Valerianella locusta, L.) lettuce cells to sugar starvation and low oxygen stress
Victor BMM, et al.
Postharvest biology and technology, 126, 23-33 (2017)
Annabell Bachem et al.
Immunity, 51(2), 285-297 (2019-07-06)
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the impact of the microbiota on CD8+ T cell memory. Antigen-activated CD8+ T cells transferred into germ-free mice failed to transition into long-lived
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