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Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Yu-Feng Zhang et al.
Clinical laboratory, 61(8), 999-1008 (2015-10-03)
Advanced glycation end products (AGEs) accumulate in the retinal vascular cells, neurons, and glias of patients with diabetes mellitus and lead to the pathogenesis of diabetic retinopathy (DR). In the present study, to elucidate the orchestrated interactions of high mobility
Piera Versura et al.
Blood transfusion = Trasfusione del sangue, 12 Suppl 1, s44-s50 (2013-10-15)
Cord blood serum (CBS)-based eye drops are successfully used in corneal epithelial wound healing and are prepared to supply a known amount of epidermal growth factor (EGF). Product standardisation includes expensive EGF dosage in all cord blood (CB) units. The
Patrick Sherwood et al.
Tree physiology, 35(5), 549-562 (2015-04-23)
Plants experiencing drought stress are frequently more susceptible to pathogens, likely via alterations in physiology that create favorable conditions for pathogens. Common plant responses to drought include the production of reactive oxygen species (ROS) and the accumulation of free amino
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single
Sumihiro Koyama et al.
Marine biotechnology (New York, N.Y.), 17(5), 678-692 (2015-08-06)
The purpose of this study was to develop a novel electrical retrieval method (ER method) for living sponge-associated microorganisms from marine sponges frozen at -80 °C. A -0.3-V vs. Ag/AgCl constant potential applied for 2 h at 9 °C induced
Sarbani Mohan et al.
Molecular immunology, 62(1), 249-264 (2014-07-22)
Streptococcus pneumoniae is a Gram-positive bacterium, causing acute sinusitis, otitis media, and severe diseases such as pneumonia, bacteraemia, meningitis and sepsis. Here we identify elongation factor Tu (Tuf) as a new Factor H binding protein of S. pneumoniae. The surface
Jason M Tonne et al.
Diabetologia, 58(2), 313-323 (2014-10-24)
Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy approaches for type 1 diabetes. In previous type 1 diabetes models, sustained immune activation eliminates regenerating beta cells, thus limiting the study
Saidan Ding et al.
The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)
We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.
Maria Clerya Alvino Leite et al.
Medical mycology, 53(3), 275-284 (2014-12-07)
Candida albicans can be a yeast that is a commensal on the human body but can cause opportunistic or pathogenic infections. Candida infections may create serious health problems and as a result has initiated a search for new drugs with
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
M Sumit et al.
Integrative biology : quantitative biosciences from nano to macro, 7(11), 1378-1386 (2015-09-17)
Many biological processes are rhythmic and proper timing is increasingly appreciated as being critical for development and maintenance of physiological functions. To understand how temporal modulation of an input signal influences downstream responses, we employ microfluidic pulsatile stimulation of a
Woong Jin Bae et al.
Journal of Korean medical science, 30(9), 1313-1320 (2015-09-05)
Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder
Ender Gedik et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 13 Suppl 1, 294-300 (2015-04-22)
The goal of this study was to compare the effects of 2 different regimens on blood glucose levels of living-donor liver transplant. The study participants were randomly allocated to the dextrose in water plus insulin infusion group (group 1, n
Johan B Fagman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1540-1550 (2015-01-01)
Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein
D R Scott et al.
Alimentary pharmacology & therapeutics, 42(11-12), 1315-1326 (2015-10-02)
The gastric H(+) ,K(+) -ATPase is the preferred target for acid suppression. Until recently, the only drugs that effectively inhibited this ATPase were the proton pump inhibitors (PPIs). PPIs are acid-activated prodrugs that require acid protection. Once acid-activated, PPIs bind
Irene de Bruijn et al.
BMC genomics, 16, 991-991 (2015-11-26)
Lysobacter species are Gram-negative bacteria widely distributed in soil, plant and freshwater habitats. Lysobacter owes its name to the lytic effects on other microorganisms. To better understand their ecology and interactions with other (micro)organisms, five Lysobacter strains representing the four
Andreina Ricci et al.
Journal of mass spectrometry : JMS, 50(1), 228-234 (2015-01-21)
Understanding on a molecular level the acid-catalysed decomposition of the sugar monomers from hemicellulose and cellulose (e.g. glucose, xylose), the main constituent of lignocellulosic biomass is very important to increase selectivity and reaction yields in solution, key steps for the development
Riccardo D'Elia et al.
BMC genomics, 10, 492-492 (2009-10-27)
Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates. The S isolate
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Ingo B Leibiger et al.
Nature medicine, 21(1), 14-16 (2015-01-09)
Nadya Shusharina et al.
International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)
To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were
Mahzad Akbarpour et al.
Science translational medicine, 7(289), 289ra81-289ra81 (2015-05-29)
Antigen (Ag)-specific tolerance in type 1 diabetes (T1D) in human has not been achieved yet. Targeting lentiviral vector (LV)-mediated gene expression to hepatocytes induces active tolerance toward the encoded Ag. The insulin B chain 9-23 (InsB9-23) is an immunodominant T
Ke Wang et al.
PloS one, 9(5), e96894-e96894 (2014-05-14)
Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on vascular complications mediated by diabetes. The
Marilyn G Wiebe et al.
Applied microbiology and biotechnology, 99(22), 9439-9447 (2015-08-13)
An open reading frame CC1225 from the Caulobacter crescentus CB15 genome sequence belongs to the Gfo/Idh/MocA protein family and has 47 % amino acid sequence identity with the glucose-fructose oxidoreductase from Zymomonas mobilis (Zm GFOR). We expressed the ORF CC1225
Jian Li et al.
Bioprocess and biosystems engineering, 38(9), 1795-1802 (2015-05-28)
Biochemical production processes require water and nutrient resources for culture media preparation, but aqueous waste is generated after the target products are extracted. In this study, culture waste (including cells) produced from a lab-scale fermenter was fed into a microbial
Roosmarijn Tm van Hooijdonk et al.
Annals of intensive care, 4(1), 8-8 (2014-03-07)
OptiScanner devices, continuous glucose monitoring devices that perform automated blood draws via a central venous catheter and create plasma through centrifugation, measure plasma glucose levels through mid-infrared spectroscopy at the bedside. The objective of this study was to determine accuracy
Justin R Yates et al.
Behavioural brain research, 291, 201-208 (2015-05-26)
Negative urgency is a facet of impulsivity that reflects mood-based rash action and is associated with various maladaptive behaviors in humans. However, the underlying neural mechanisms of negative urgency are not fully understood. Several brain regions within the mesocorticolimbic pathway
S Villarruel et al.
Materials science & engineering. C, Materials for biological applications, 56, 545-554 (2015-08-08)
This work was focused on: i) developing single and blend films based on carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVOH) studying their properties, ii) analyzing the interactions between CMC and PVOH and their modifications UV-induced in the presence of sodium
Alison Ludzki et al.
Diabetes, 64(8), 2769-2779 (2015-04-08)
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current
Christophe Varin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9900-9911 (2015-07-15)
Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we
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