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Megan M Maurer et al.
Journal of proteomics, 130, 85-93 (2015-09-17)
Mounting evidence suggests that pulmonary exposure to nanoparticles (NPs) has a toxic effect on biological systems. A number of studies have shown that exposure to NPs result in systemic inflammatory response, oxidative stress, and leukocyte adhesion. However, significant knowledge gaps
National Toxicology Program technical report series, 477, 1-264 (2003-02-07)
1-Chloro-2-propanol and its positional isomer, 2-chloro-1-propanol, are used as chemical intermediates for the manufacture of propylene oxide, a starting material for production of polyurethane polyols and propylene glycol. The National Cancer Institute nominated 1-chloro-2-propanol for study because of potential for
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of
Nick B Paulson et al.
PloS one, 9(10), e111441-e111441 (2014-10-29)
The arginine decarboxylase pathway, which converts arginine to agmatine, is present in both humans and most bacterial pathogens. In humans agmatine is a neurotransmitter with affinities towards α2-adrenoreceptors, serotonin receptors, and may inhibit nitric oxide synthase. In bacteria agmatine serves
Natalia Malachowa et al.
PloS one, 10(2), e0117713-e0117713 (2015-02-27)
Staphylococcus aureus is an important cause of human skin and soft tissue infections (SSTIs) globally. Notably, 80% of all SSTIs are caused by S. aureus, of which ∼63% are abscesses and/or cellulitis. Although progress has been made, our knowledge of
Shu-Ting Pan et al.
Drug design, development and therapy, 9, 937-968 (2015-03-04)
5,6-Dimethylxanthenone 4-acetic acid (DMXAA), also known as ASA404 and vadimezan, is a potent tumor blood vessel-disrupting agent and cytokine inducer used alone or in combination with other cytotoxic agents for the treatment of non-small cell lung cancer (NSCLC) and other
Fatemeh Haghighi et al.
Journal of neurotrauma, 32(16), 1200-1209 (2015-01-17)
Long-term molecular changes in the brain resulting from blast exposure may be mediated by epigenetic changes, such as deoxyribonucleic acid (DNA) methylation, that regulate gene expression. Aberrant regulation of gene expression is associated with behavioral abnormalities, where DNA methylation bridges
Ritwika Ray et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(47), 15618-15624 (2014-10-07)
The present article describes novel oxidative protocols for direct esterification of alcohols. The protocols involve successful demonstrations of both "cross" and "self" esterification of a wide variety of alcohols. The cross-esterification proceeds under a simple transition-metal-free condition, containing catalytic amounts
Ana García-Sacristán et al.
Nucleic acids research, 43(1), 565-580 (2014-12-17)
The 5' untranslated region of hepatitis C virus (HCV) genomic RNA contains an internal ribosome entry site (IRES) element, composed of domains II-IV, which is required for cap-independent translation initiation. Little information on the 3D structure of the whole functional
Stefania Ghisaura et al.
Proteome science, 12(1), 44-44 (2014-10-25)
The zootechnical performance of three different commercial feeds and their impact on liver and serum proteins of gilthead sea bream (Sparus aurata, L.) were assessed in a 12 week feeding trial. The three feeds, named A, B, and C, were subjected
Sun H Peck et al.
Molecular genetics and metabolism, 116(3), 195-203 (2015-10-01)
Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, which leads to the accumulation of incompletely degraded glycosaminoglycans (GAGs). MPS VII patients present with severe skeletal abnormalities, which are particularly prevalent in the spine. Incomplete cartilage-to-bone
Kyle D Dukes et al.
Analytical biochemistry, 458, 43-48 (2014-04-24)
Silver nanoparticles have been modified with self-assembled monolayers of hydroxyl-terminated long chain thiols and encapsulated with a silica shell. The resulting core-shell nanoparticles were used as optical labels for cell analysis using flow cytometry and microscopy. The excitation of plasmon
Ottmar Golf et al.
Journal of the American Society for Mass Spectrometry, 26(1), 44-54 (2014-11-09)
Here we present a proof of concept cross-platform normalization approach to convert raw mass spectra acquired by distinct desorption ionization methods and/or instrumental setups to cross-platform normalized analyte profiles. The initial step of the workflow is database driven peak annotation
Jeanette N McClintick et al.
Pharmacology, biochemistry, and behavior, 129, 87-96 (2014-12-30)
Alcohol binge-drinking during adolescence is a serious public health concern with long-term consequences. We used RNA sequencing to assess the effects of excessive adolescent ethanol binge-drinking on gene expression in the dorsal raphe nucleus (DRN) of alcohol preferring (P) rats.
Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully
Jianjian Lin et al.
Scientific reports, 4, 5769-5769 (2014-08-30)
Three-dimensional (3D) hierarchical nanoscale architectures comprised of building blocks, with specifically engineered morphologies, are expected to play important roles in the fabrication of 'next generation' microelectronic and optoelectronic devices due to their high surface-to-volume ratio as well as opto-electronic properties.
Tadashi Yamamuro et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 85-94 (2014-08-30)
A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, thiacloprid and thiamethoxam) and three specific metabolites of acetamiprid (N-desmethylacetamiprid, 5-(N-acetyl-N-methylaminomethyl)-2-chloropyridine and 5-(N-acetylaminomethyl)-2-chloropyridine) in human serum and urine. A
Jannick Clemens et al.
Cancer chemotherapy and pharmacology, 75(2), 281-291 (2014-12-06)
Despite overall successful application to multiple myeloma patients, clinical efficacy of the proteasome inhibitor bortezomib is typically challenged by primary and secondary resistance of unknown origin. So far, the potential impact of intracellular concentrations on drug efficacy of bortezomib and
Christiane Rieger et al.
International journal of pharmaceutics, 479(2), 357-363 (2015-01-18)
In order to increase the effectiveness of therapeutics for bladder carcinoma (BCa) treatment, alternative strategies for intravesical applications are needed. The use of carbon nanotubes (CNTs) as basis for a multifunctional drug transporter is a promising possibility to combine traditional
Derek R Stein et al.
AIDS (London, England), 29(1), 35-41 (2015-01-07)
Recent studies have identified Mx2 as a novel HIV-1 innate restriction factor that inhibits proviral integration. A pilot proteomic study of immune cells from highly exposed HIV-seronegative (HESN) individuals enrolled in the Pumwani sex worker cohort identified Mx1 as potential
Rattikorn Intarakumhaeng et al.
International journal of pharmaceutics, 476(1-2), 266-276 (2014-09-28)
Understanding the effects of solvents upon percutaneous absorption can improve drug delivery across skin and allow better risk assessment of toxic compound exposure. The objective of the present study was to examine the effects of solvents upon the deposition of
Julie A Ray et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 330-336 (2014-08-12)
Challenges for steroid analysis by LC-MS/MS include low ionization efficiency, endogenous isobars with similar fragmentation patterns and chromatographic retention. Differential ion mobility spectrometry (DMS) provides an additional degree of separation prior to MS/MS detection, and shows promise in improving specificity
Junwen Chen et al.
Journal of translational medicine, 12, 326-326 (2014-11-27)
Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the clinical application of BBR is limited by its poor bioavailability. Derivatives of BBR have been suggested to have enhanced bioavailability compared to BBR. In
Mauricio Garrido et al.
Journal of endodontics, 41(4), 464-469 (2015-03-10)
C-reactive protein (CRP) is the prototype component of acute-phase proteins induced ultimately by interleukin (IL)-6 in the liver, but it is unknown whether periradicular tissues locally express CRP. The present study aimed to identify whether CRP messenger RNA synthesis occurs
Alexey S Sizov et al.
Langmuir : the ACS journal of surfaces and colloids, 30(50), 15327-15334 (2014-11-26)
Self-assembly of highly soluble water-stable tetramethyldisiloxane-based dimer of α,α'-dialkylquaterthiophene on the water-air interface was investigated by Langmuir, grazing incidence X-ray diffraction, and X-ray reflectivity techniques. The conditions for formation of very homogeneous crystalline monolayer Langmuir-Blodgett (LB) films of the oligomer
Prapaporn Boonme et al.
Journal of cosmetic science, 63(6), 397-406 (2013-01-05)
The aim of this study was to investigate physicochemical characteristics and to determine in vitro release kinetics of prepared nicotinamide microemulsion-based gels (MBGs). Nicotinamide microemulsions (ME) were composed of 3% w/w nicotinamide, 7% w/w water, 25% w/w soybean oil, and
Dubravka Vučićević et al.
Cell cycle (Georgetown, Tex.), 14(2), 253-260 (2015-01-22)
Long non-coding RNAs (ncRNA) have recently been demonstrated to be expressed from a subset of enhancers and to be required for the distant regulation of gene expression. Several approaches to predict enhancers have been developed based on various chromatin marks
Shaoping Ling et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6496-E6505 (2015-11-13)
The prevailing view that the evolution of cells in a tumor is driven by Darwinian selection has never been rigorously tested. Because selection greatly affects the level of intratumor genetic diversity, it is important to assess whether intratumor evolution follows
Markus Theurl et al.
Cardiovascular research, 105(1), 96-106 (2014-11-08)
Hypercholesterolaemia is a major risk factor for cardiovascular diseases and has been shown to influence angiogenesis in the hind limb ischaemia (HLI) model. The impaired up-regulation of angiogenic factors seems to be one of the underlying mechanisms for reduced vessel
Jianru Shi et al.
Life sciences, 141, 170-178 (2015-10-04)
We have observed that Bendavia, a mitochondrial-targeting peptide that binds the phospholipid cardiolipin and stabilizes the components of electron transport and ATP generation, improves cardiac function and prevents left ventricular remodeling in a 6week rat myocardial infarction (MI) model. We
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