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Jacqueline M Wurst et al.
ACS chemical biology, 9(7), 1536-1544 (2014-05-16)
Pseudomonas aeruginosa produces the peptide siderophore pyoverdine, which is used to acquire essential Fe(3+) ions from the environment. PvdQ, an Ntn hydrolase, is required for the biosynthesis of pyoverdine. PvdQ knockout strains are not infectious in model systems, suggesting that
Megumi Hirokawa et al.
European journal of human genetics : EJHG, 23(3), 374-380 (2014-06-12)
Despite considerable progress in preventive and therapeutic strategies, myocardial infarction (MI) is one of the leading causes of death throughout the world. A total of 55 susceptibility genes have been identified mostly in European genome-wide association studies (GWAS). Nevertheless, large-scale
Kristina Kirschner et al.
PLoS genetics, 11(3), e1005053-e1005053 (2015-03-20)
The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide information about p53-target gene regulation has been derived mostly
Diane C Munday et al.
The Journal of pharmacy and pharmacology, 67(3), 300-318 (2014-12-24)
The aim of this study was to quantitatively characterise the mitochondrial proteome of airway epithelial cells infected with human respiratory syncytial virus (HRSV), a major cause of paediatric illness. Quantitative proteomics, underpinned by stable isotope labelling with amino acids in
Kazuhiko Kurosawa et al.
Bioresource technology, 193, 206-212 (2015-07-05)
Extracting lipids from oleaginous microbial cells in a cost effective and environmentally compatible manner remains a critical challenge in developing manufacturing paradigms for advanced liquid biofuels. In this study, a new approach using microbial growth inhibitors from lignocellulose-derived feedstocks was
Sabrina D Lamour et al.
PLoS neglected tropical diseases, 9(10), e0004200-e0004200 (2015-10-28)
Human African trypanosomiasis (HAT) remains a major neglected tropical disease in Sub-Saharan Africa. As clinical symptoms are usually non-specific, new diagnostic and prognostic markers are urgently needed to enhance the number of identified cases and optimise treatment. This is particularly
Ying Zhang et al.
Analytical biochemistry, 484, 40-50 (2015-05-20)
Dendritic cells (DCs) are specialized leukocytes that orchestrate the adaptive immune response. Mass spectrometry (MS)-based proteomic study of these cells presents technical challenges, especially when the DCs are human in origin due to the paucity of available biological material. Here
Kylie R Dunning et al.
Biology of reproduction, 92(5), 116-116 (2015-03-27)
In vitro maturation of oocytes is suboptimal to in vivo maturation with altered gene expression and compromised oocyte quality. The large proteoglycan versican is abundant in mouse cumulus-oocyte complexes (COCs) matured in vivo but is absent in cultured COCs. Versican
Kim De Nolf et al.
Journal of the American Chemical Society, 137(7), 2495-2505 (2015-01-30)
We investigate the relation between the chain length of ligands used and the size of the nanocrystals formed in the hot injection synthesis. With two different CdSe nanocrystal syntheses, we consistently find that longer chain carboxylic acids result in smaller
Karthyayani Rajamani et al.
Cell transplantation, 24(3), 493-507 (2015-02-06)
As assuring cell quality is an essential parameter for the success of stem cell therapy, the impact of various senescence-inducing stress signals, and strategies to circumvent them, has been an important area of focus in stem cell research. The aim
Patrícia Henriques Domingues et al.
Neuropathology and applied neurobiology, 41(3), 319-332 (2014-03-13)
Limited information exists about the impact of cytogenetic alterations on the protein expression profiles of individual meningioma cells and their association with the clinicohistopathological characteristics of the disease. The aim of this study is to investigate the potential association between
Ho-Hsien Lee et al.
IUCrJ, 1(Pt 5), 305-317 (2014-10-09)
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein of Human immunodeficiency virus 1 (HIV-1), and has previously been shown to induce the production of
A C Mamede et al.
Medical oncology (Northwood, London, England), 32(12), 257-257 (2015-10-29)
Hepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the
Seiichiro Aoe et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1141-1146 (2015-04-03)
Konjac-mannan has been suggested to exert a protective effect against visceral obesity. However, there is little knowledge about the effects of liquid konjac (LK) that is partially alkali gelled. The purpose of the present work was to evaluate the potential
Kelly M Mabry et al.
Biomaterials, 74, 31-41 (2015-10-05)
Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we
Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs
Daniel M Kulakowski et al.
Journal of chromatography. A, 1364, 74-82 (2014-09-15)
This study presents a strategy based on repeatable reversed-phase LC-TOF-MS methods and chemometric statistical tools, including untargeted PCA and supervised OPLS-DA models, to identify low-yielding compounds with potent immunostimulant activity in Phaleria nisidai (Thymelaeaceae), a plant with a history of
Aleksandr Perevedentsev et al.
Nature communications, 6, 5977-5977 (2015-01-20)
Metamaterials are a promising new class of materials, in which sub-wavelength physical structures, rather than variations in chemical composition, can be used to modify the nature of their interaction with electromagnetic radiation. Here we show that a metamaterials approach, using
Yun-Ying Zhang et al.
Biomedical chromatography : BMC, 28(7), 1030-1035 (2014-01-15)
A novel online column-switching chiral high-performance liquid chromatography method was developed and validated for the simultaneous determination of naftopidil (NAF) and its O-desmethyl metabolites (DMN) enantiomers in rat feces. Direct and multiple injections of supernatant from rat feces homogenate were
Hyun-Woo Kang et al.
Faraday discussions, 176, 287-299 (2014-11-20)
The effect of double blocking layers on the Sb(2)S(3)-sensitized all solid state solar cell are investigated. Thin layers of ZrO(2) (blocking layer 1, BL1) and ZnS (blocking layer 2, BL2) are introduced at the TiO(2)/Sb(2)S(3) and Sb(2)S(3)/hole transporting material (HTM)
Denis A Babkov et al.
Bioorganic & medicinal chemistry, 23(21), 7035-7044 (2015-10-08)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives--previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of
Dieter Buyst et al.
Nucleic acids research, 43(1), 51-62 (2014-12-19)
The predictable 3D structure of double-stranded DNA renders it ideally suited as a template for the bottom-up design of functionalized nucleic acid-based active sites. We here explore the use of a 14mer DNA duplex as a scaffold for the precise
Uta Delling et al.
Cell transplantation, 24(11), 2391-2407 (2015-01-13)
In this study, the therapeutic effect of intra-articularly injected autologous mesenchymal stromal cells (MSCs) was evaluated in an ovine osteoarthritis (OA) model using consecutive magnetic resonance imaging (MRI), radiography, and macroscopic and histologic postmortem examination. In 12 sheep, OA was
Sigalit Meker et al.
ChemMedChem, 9(6), 1294-1298 (2014-03-29)
Nanoparticles of titanium(IV) complexes of phenolato ligands were formed and evaluated for cytotoxicity toward human HT-29 colon cancer, murine T-25 lymphoma, and murine HU-2 multidrug-resistant (MDR) cells. The nano-formulation, besides increasing the complexes' shelf lives, is particularly efficient in overcoming
Kun Liu et al.
International journal of molecular medicine, 36(3), 817-824 (2015-07-15)
The aim of this study was to investigate the role of microRNAs (miRNAs or miRs) in vascular smooth muscle cell (VSMC) proliferation and to elucidate the underlying molecular mechanisms. In a previous study, using microarray analysis, differentially expressed miRNAs were
Weronika Hewelt-Belka et al.
Journal of chromatography. A, 1362, 62-74 (2014-08-28)
Staphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a
Andrea G Edlow et al.
American journal of obstetrics and gynecology, 213(1), 59-59 (2015-03-17)
'Omics analysis of large datasets has an increasingly important role in perinatal research, but understanding gene expression analyses in the fetal context remains a challenge. We compared the interpretation provided by a widely used systems biology resource (ingenuity pathway analysis
Wen-feng Gou et al.
Oncotarget, 6(23), 19552-19579 (2015-05-20)
Here, we found that ING5 overexpression increased autophagy, differentiation, and decreased proliferation, apoptosis, migration, invasion and lamellipodia formation in gastric cancer cells, while ING5 knockdown had the opposite effects. In SGC-7901 transfectants, ING5 overexpression caused G1 arrest, which was positively
Aurélie Goncalves et al.
The Journal of biological chemistry, 289(44), 30743-30752 (2014-09-18)
Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and
Khaled Mohamed Hosny et al.
International journal of pharmaceutics, 475(1-2), 191-197 (2014-09-03)
Saquinavir mesylate (SM) is a protease inhibitor with activity against human immunodeficiency virus type 1 (HIV-1) and is available in tablet form, which has three major problems. First, the drug undergoes extensive first pass metabolism. Second, the drug has a
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