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Sara M Villani et al.
Phytopathology, 104(9), 945-953 (2014-03-15)
Quantitative (partial) and qualitative (complete) resistance responses to quinone outside inhibitor (QoI) fungicides have been documented for the apple scab pathogen Venturia inaequalis. Resistance monitoring efforts have traditionally focused on the detection of qualitative resistance based on a single point
Maria Teresa Montagna et al.
Journal of medical microbiology, 63(Pt 12), 1638-1643 (2014-09-12)
We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards
Raiyan T Zaman et al.
PloS one, 9(9), e108108-e108108 (2014-09-19)
Atherosclerosis is a progressive inflammatory condition that underlies coronary artery disease (CAD)-the leading cause of death in the United States. Thus, the ultimate goal of this research is to advance our understanding of human CAD by improving the characterization of
Louise S Dalbøge et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 353-360 (2014-06-07)
Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDF-NH2) on glycemic control, β-cell mass and
Lutgarda Bozzetto et al.
Diabetologia, 58(7), 1551-1560 (2015-04-25)
Dietary polyphenols and long chain n-3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3
Tao Ren et al.
Drug design, development and therapy, 9, 2887-2910 (2015-06-20)
AT-101 is a BH3 mimetic and pan-Bcl-2 inhibitor that has shown potent anticancer activity in non-small-cell lung cancer (NSCLC) in murine models, but failed to show clinical efficacy when used in combination with docetaxel in NSCLC patients. Our recent study
Edisson Chavarro Mesa et al.
Phytopathology, 105(11), 1475-1486 (2015-07-30)
The fungus Rhizoctonia solani anastomosis group (AG)-1 IA emerged in the early 1990s as an important pathogen causing foliar blight and collar rot on pastures of the genus Urochloa (signalgrass) in South America. We tested the hypothesis that this pathogen
Marina Barandun et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1111-1119 (2015-05-23)
We investigated whether nasal chondrocytes (NC) can be used to generate composite constructs with properties necessary for the repair of osteochondral (OC) lesions, namely maturation, integration and capacity to recover from inflammatory burst. OC grafts were fabricated by combining engineered
Vijayashankar Nataraj et al.
PloS one, 10(3), e0122804-e0122804 (2015-04-22)
Lipooligosaccharides are glycolipids found in the cell wall of many mycobacterial species including the opportunistic pathogen Mycobacterium kansasii. The genome of M. kansasii ATCC12478 contains a cluster with genes orthologous to Mycobacterium marinum LOS biosynthesis genes. To initiate a genetic
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
Chun-Yi Chiu et al.
Ultrasound in medicine & biology, 41(7), 1842-1852 (2015-04-30)
This study was performed to investigate osteoblastogenesis of human mesenchymal stem cells (hMSCs) cultured in 3-D scaffolds stimulated with low-intensity pulsed ultrasound and to identify the underlying mechanism mediated by soluble receptor activator of nuclear factor kappa B ligand (sRANKL)
Yiying Liu et al.
PloS one, 10(8), e0136241-e0136241 (2015-09-01)
Emerging fungal and oomycete pathogens are increasingly threatening animals and plants globally. Amongst oomycetes, Saprolegnia species adversely affect wild and cultivated populations of amphibians and fish, leading to substantial reductions in biodiversity and food productivity. With the ban of several
Amanda K Chaplin et al.
The Biochemical journal, 469(3), 433-444 (2015-07-25)
Streptomyces lividans displays a distinct dependence on copper to fully initiate morphological development. Evidence has accumulated to implicate the participation of an extracytoplasmic cuproenzyme in morphogenesis. In the present study, we show that GlxA fulfils all criteria to be that
Ali Fakhri et al.
Journal of photochemistry and photobiology. B, Biology, 149, 45-50 (2015-06-06)
Nanoscale SnO2, SnS2 and SnO2/SnS2 were synthesized by hydrothermal treatment method and characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Barrett-Joyner-Halenda (BJH) and UV-vis spectra. The photocatalytic activity of SnO2, SnS2 and
Ramazan Gümral et al.
Turkish journal of medical sciences, 45(3), 587-592 (2015-08-19)
Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of
Edward T Wargent et al.
PeerJ, 3, e753-e753 (2015-02-24)
The literature is unclear on whether the adipokine chemerin has pro- or anti-inflammatory properties or plays any role in the aetiology of type 2 diabetes or obesity. To address these questions, and in particular the potential of agonists or antagonists
Irene Taurino et al.
Scientific reports, 5, 15277-15277 (2015-10-31)
Novel methods to obtain Pt nanostructured electrodes have raised particular interest due to their high performance in electrochemistry. Several nanostructuration methods proposed in the literature use costly and bulky equipment or are time-consuming due to the numerous steps they involve.
Adam G Hotchkiss et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1847-1854 (2015-09-16)
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the
Nilgün Karabıçak et al.
Mycopathologia, 180(3-4), 165-171 (2015-05-15)
Dermatophytes can invade the stratum corneum of the skin and other keratinized tissues and are responsible for a broad diversity of diseases of skin, nails and hair. Although the standard identification of dermatophytoses depends on macroscopic and microscopic characterization of
Fengqin Yang et al.
Journal of ethnopharmacology, 163, 88-93 (2015-01-28)
A series of 40 important Traditional Chinese Medicines (TCMs), which were reported effective in treating superficial fungal infections of the skin in Chinese clinical trial publications and Chinese Herbal Classics, were chosen for the investigation of the individual and combination
Roupen Hatzakorzian et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(11), 1380-1387 (2014-09-27)
We investigated the effect of insulin administered as part of a hyperinsulinemic-normoglycemic clamp on protein metabolism after coronary artery bypass grafting (CABG) surgery. Eighteen patients were studied, with nine patients in the control group receiving standard metabolic care and nine
Beng Fye Lau et al.
PloS one, 9(7), e102509-e102509 (2014-07-24)
Previous studies on the nutritional and nutraceutical properties of Lignosus rhinocerotis focused mainly on the sclerotium; however, the supply of wild sclerotium is limited. In this investigation, the antioxidant capacity and cytotoxic effect of L. rhinocerotis cultured under different conditions
Hao Wang et al.
The journal of trauma and acute care surgery, 77(6), 926-933 (2014-09-24)
Hemorrhagic shock (HS) may contribute to organ failure, by profoundly altering mitochondrial function. Resveratrol (RSV), a naturally occurring polyphenol, has been shown to promote mitochondrial function and regulate glucose homeostasis in diabetes. We hypothesized that RSV during resuscitation would ameliorate
X Zhao et al.
International journal of molecular medicine, 35(3), 684-692 (2015-01-13)
Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein
Foyez Mahmud et al.
Molecular pharmaceutics, 12(6), 1911-1920 (2015-04-22)
Currently, oral administration of insulin still remains the best option to avoid the burden of repeated subcutaneous injections and to improve its pharmacokinetics. The objective of the present investigation was to demonstrate the absorption mechanism of insulin in the physical
Sangkyu Park et al.
PloS one, 9(10), e109453-e109453 (2014-10-07)
Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol level and lesion size in fruits infected with Colletotrichum gloeosporioides, depending on the stage
A M Poff et al.
PloS one, 10(6), e0127407-e0127407 (2015-06-11)
The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric oxygen (KD+HBOT) and dietary ketone supplementation
Mercè Tena-Campos et al.
Biochimica et biophysica acta, 1852(12), 2585-2592 (2015-09-15)
GPR39 is a class A G protein-coupled receptor involved in zinc binding and glucose homeostasis regulation, among other physiological processes. GPR39 was originally thought to be the receptor for obestatin peptide but this view has been challenged. However, activation of
Neha Kaushik et al.
Scientific reports, 5, 8726-8726 (2015-03-05)
In this study, we show the selective and efficient anti-cancer effects of plasma (at a low dose) when cell metabolic modifiers are also included. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor, was used with effective doses of non-thermal plasma, synergistically attenuating cell
Panida Thanyasrisung et al.
Journal of medical microbiology, 63(Pt 5), 753-759 (2014-03-05)
Oral candidiasis is a common opportunistic infection among human immunodeficiency virus (HIV)-infected individuals, with growing concerns about the emergence of non-albicans species with resistance to antifungal agents. This cross-sectional study determined the prevalence of oral Candida species in Thai HIV-infected
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