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Corina Danciu et al.
Natural product communications, 10(6), 951-954 (2015-07-23)
In recent years polyurethane microstructures (PM) have gained increasing attention in the pharmaceutical field due to the importance of their practical application. Since finding that such a formulation with genistein could improve its applications, we have conducted a preliminary study
Ferran Jardi et al.
Journal of neurogastroenterology and motility, 21(2), 222-235 (2015-04-07)
Enteric dysbiosis is a risk factor for dietary proteins-associated intestinal alterations, contributing to the development of food allergies and the symptomatology of functional gastrointestinal disorders, mainly irritable bowel syndrome (IBS). We explored if a dysbiotic-like state, simulated by intraperitoneal administration
D G Bailey et al.
Journal of chromatography, 111(2), 305-311 (1975-09-03)
A method is presented for the measurement of 6-mercaptopurine (6-MP) in serum. Serum samples containing the drug were treated with dithioerythritol and saturated with ammonium carbonate. 6-MP was then extracted from the serum with a mixture of isopropanol-ethyl acetate (1:1
Martha L Slattery et al.
BMC medicine, 13, 75-75 (2015-04-19)
Studies of colorectal cancer (CRC) have shown that hundreds to thousands of genes are differentially expressed in tumors when compared to normal tissue samples. In this study, we evaluate how genes that are differentially expressed in colon versus normal tissue
H Yeşim Karasulu et al.
Journal of drug targeting, 23(6), 525-537 (2015-03-05)
The aim of this study was to develop aprotinin-loaded microemulsion (MA) for intravenous administration and evaluate the biodistribution and therapeutic potential of developed formulation in acute pancreatitis models in rats. Phase diagrams were constructed to identify microemulsion region and the
Marumi Ohno et al.
PloS one, 9(12), e115663-e115663 (2014-12-30)
Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO) mice and demonstrated that
Oscar Cordero-Llana et al.
Experimental neurology, 256, 93-104 (2014-04-15)
Galanin is a pleiotropic neuropeptide widely expressed in the nervous system. It plays a role in many diverse physiological functions - including nociception, cognition and metabolism regulation - and acts as neurotrophic/neuroprotective factor for several neuronal populations. In this article
Xinmin Zhao et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6733-6740 (2015-04-03)
Lung cancer is the leading cause of cancer-related death in the world. Previous report has identified ribosomal protein s15a (RPS15A) as a TGF-β-responsible gene in the lung adenocarcinoma cell line A549. In this study, we used specific si-RNA to downregulate
Malia Su-Qin Murphy et al.
American journal of obstetrics and gynecology, 213(6), 853-853 (2015-10-18)
The long-term maternal cardiovascular and metabolic implications associated with preeclampsia (PE) include risk of hypertension, heart disease, and metabolic syndrome. The objective of this study was to investigate if a recent history of PE was associated with detectable alterations in
Cédric Maerckx et al.
World journal of gastroenterology, 20(30), 10553-10563 (2014-08-19)
To test the ability of adult-derived human liver stem/progenitor cells (ADHLSC) from large scale cultures to conjugate bilirubin in vitro and in bilirubin conjugation deficient rat. ADHLSC from large scale cultures were tested for their phenotype and for their capacity
Gabriel A Goldfien et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(7), 814-828 (2015-01-31)
Epidemiological studies indicate that progestin-containing contraceptives increase susceptibility to HIV, although the underlying mechanisms involving the upper female reproductive tract are undefined. To determine the effects of depot medroxyprogesterone acetate (DMPA) and the levonorgestrel intrauterine system (LNG-IUS) on gene expression
Magdalene H Y Tang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 272-284 (2014-09-10)
Novel psychoactive substances (NPS) are becoming increasingly popular worldwide in recent years, some of which have been reported to cause considerable harm and even fatalities. Currently, simultaneous screening for a comprehensive panel of conventional and novel drugs of abuse is
Paul Luigi Gargani Weisbjerg et al.
Journal of pharmaceutical sciences, 104(2), 548-556 (2014-12-03)
Aggregation levels of therapeutic proteins may be difficult to determine in mixtures containing other proteinaceous excipients. We performed a feasibility study of using serial coupling of an anion exchange and size exclusion column to determine the aggregation levels of four
Rosica S Petrova et al.
Experimental eye research, 132, 124-135 (2015-01-18)
The expression of the water channel protein aquaporin (AQP)-5 in adult rodent and human lenses was recently reported using immunohistochemistry, molecular biology, and mass spectrometry techniques, confirming a second transmembrane water channel that is present in lens fibre cells in
Huashan Zhao et al.
Scientific reports, 5, 7913-7913 (2015-01-22)
G protein-coupled receptors (GPCRs) mediate multiple key biological processes in the body. The orphan receptor GPR39 has been reported to be involved in various pathophysiological events. However, the function of GPR39 in skin biology remains unknown. Using a genetically engineered
Danshan Huang et al.
Lipids in health and disease, 10, 20-20 (2011-01-26)
Obesity, type 2 diabetes and hyperlipidemia frequently coexist and are associated with significantly increased morbidity and mortality. Consumption of refined carbohydrate and particularly fructose has increased significantly in recent years and has paralled the increased incidence of obesity and diabetes.
Jun Cheng et al.
Bioresource technology, 191, 66-72 (2015-05-20)
Instant catapult steam explosion (ICSE) was employed to disrupt wet microalgal cells for efficient lipid extraction. Physicochemical properties of exploded cells were investigated through SEM, TEM, FTIR, and TGA. The exploded cells increased in fractal dimension (1.53-1.65) when preheat time
Vanessa Andries et al.
BMC cancer, 15, 391-391 (2015-05-11)
NBPF1 (Neuroblastoma Breakpoint Family, member 1) was originally identified in a neuroblastoma patient on the basis of its disruption by a chromosomal translocation t(1;17)(p36.2;q11.2). Considering this genetic defect and the frequent genomic alterations of the NBPF1 locus in several cancer
Bert Wouters et al.
Lab on a chip, 15(23), 4415-4422 (2015-10-24)
In order to successfully tackle the truly complex separation problems arising from areas such as proteomics research, the development of ultra-efficient and fast separation technology is required. In spatial three-dimensional chromatography, components are separated in the space domain with each
Iftach Nir et al.
Biophysical journal, 108(9), 2340-2349 (2015-05-09)
Nanopore sensing involves an electrophoretic transport of analytes through a nanoscale pore, permitting label-free sensing at the single-molecule level. However, to date, the detection of individual small proteins has been challenging, primarily due to the poor signal/noise ratio that these
Ramani Soundararajan et al.
PloS one, 9(10), e110299-e110299 (2014-10-31)
Mutations in the membrane frizzled-related protein (MFRP/Mfrp) gene, specifically expressed in the retinal pigment epithelium (RPE) and ciliary body, cause nanophthalmia or posterior microphthalmia with retinitis pigmentosa in humans, and photoreceptor degeneration in mice. To better understand MFRP function, microarray
Su Yun Lee et al.
Food chemistry, 165, 157-166 (2014-07-21)
In this study, a comprehensive metabolite profile analysis of doenjang, a fermented soybean paste, at various steps of its industrial 5-step production process was conducted, by combining gas and liquid chromatography-mass spectrometry techniques with multivariate analysis. From the partial least
Eun Gyung Lee et al.
Journal of occupational and environmental hygiene, 10(2), 97-108 (2012-12-21)
This study introduces two semi-quantitative methods, Structured Subjective Assessment (SSA) and Control of Substances Hazardous to Health (COSHH) Essentials, in conjunction with two-dimensional Monte Carlo simulations for determining prior probabilities. Prior distribution using expert judgment was included for comparison. Practical
S Matsumura et al.
Oral diseases, 21(3), 361-372 (2014-09-03)
The characteristics of cell populations extracted from oral mucosal non-epithelial tissues and their ability to differentiate were evaluated in vitro as a potential source of cells for mandibular and corneal regeneration. Oral mucosal non-epithelial cells (OMNECs) were extracted from tissue
Yuting Chen et al.
Nanoscale, 7(17), 7770-7779 (2015-04-08)
Herein, we present a systematic study on the development, optical optimization and sensing applicability of colored photonic coatings based on nanoporous anodic alumina films grown on aluminum substrates. These optical nanostructures, so-called distributed Bragg reflectors (NAA-DBRs), are fabricated by galvanostatic
Wei Xie et al.
Nature communications, 6, 7570-7570 (2015-07-04)
Noble metals are important photocatalysts due to their ability to convert light into chemical energy. Hot electrons, generated via the non-radiative decay of localized surface plasmons, can be transferred to reactants on the metal surface. Unfortunately, the number of hot
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers
A P Sobinoff et al.
Human reproduction (Oxford, England), 29(12), 2719-2735 (2014-10-02)
What are the effects on fertility of cigarette smoke-induced toxicity on male offspring exposed during the gestational/weaning period? Maternal cigarette smoke exposure during the gestational/weaning period causes long-term defects in male offspring fertility. Cigarette smoke is a well-known reproductive toxicant
C A Moore et al.
Toxicology letters, 229(1), 257-264 (2014-06-10)
Organophosphates (OPs) are widely used in agriculture. Many studies have investigated the capability of personal protective equipment (PPE) to reduce chemical exposure; however, investigations into the protective effect of 'every-day' clothing are rare. The purpose of this study was to
Simone E Barry et al.
Journal of cellular and molecular medicine, 19(7), 1606-1613 (2015-03-11)
Tuberculosis (TB) remains a major public health issue. New tests to aid diagnoses and monitor the response to therapy are urgently required. There is growing interest in the use of microRNA (miRNA) profiles as diagnostic, prognostic or predictive markers in
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