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Charlotte van Rooijen et al.
Journal of agricultural and food chemistry, 62(35), 8883-8891 (2014-08-05)
During processing of pet food, the Maillard reaction occurs, which reduces the bioavailability of essential amino acids such as lysine and results in the formation of advanced Maillard reaction products (MRPs). The aim of this study was to quantitate MRPs
Jui-Ling Hsu et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(10), 979-990 (2014-07-10)
Hormone-refractory metastatic prostate cancer (HRMPC), which is metastatic and resistant to hormone therapy, is an intractable problem in clinical treatment. Anthraquinone-based natural products and synthetic compounds have shown anticancer activity. However, cardiac toxicity is a major adverse reaction in these
Inga Müller et al.
PloS one, 9(5), e97285-e97285 (2014-05-27)
Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with MYCN-amplified neuroblastoma have a poor prognosis, targeting MYCN using small molecule inhibitors
Fidan O Can et al.
Journal of food protection, 77(10), 1723-1731 (2014-10-07)
Cheese is a ready-to-eat food that may be contaminated on the surface by undesirable spoilage and pathogenic microorganisms during production, packaging, and postpackaging processes. Penicillium roqueforti is commonly found on cheese surfaces at refrigeration temperatures and is one of the
Hong-Mei Li et al.
Journal of Asian natural products research, 17(7), 761-766 (2015-01-16)
Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination
Eline Saenen et al.
International journal of molecular sciences, 16(6), 12405-12423 (2015-06-05)
To evaluate the environmental impact of uranium (U) contamination, it is important to investigate the effects of U at ecologically relevant conditions. Since U speciation, and hence its toxicity, strongly depends on environmental pH, the present study aimed to investigate
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Zidong Liu et al.
Environmental toxicology and chemistry, 34(9), 2033-2040 (2015-04-23)
Microcystin-LR (MC-LR) has the potential to disturb thyroid hormone homeostasis, but little is known about the underlying mechanisms of MC-LR in fish. In the present study, juvenile Chinese rare minnows (Gobiocypris rarus) were exposed to various concentrations of MC-LR (0 µg/L
Johnni Hansen et al.
Journal of the National Cancer Institute, 105(12), 869-877 (2013-06-01)
Trichloroethylene (TCE) is a widely used chlorinated solvent with demonstrated carcinogenicity in animal assays. Some epidemiologic studies have reported increased risk of cancer of the kidney, cervix, liver and biliary passages, non-Hodgkin lymphoma, and esophageal adenocarcinoma. We established a pooled
David J Burke et al.
International journal of molecular sciences, 16(10), 23630-23650 (2015-10-09)
In this study, we investigated the effect of positively and negatively charged Fe₃O₄ and TiO₂ nanoparticles (NPs) on the growth of soybean plants (Glycine max.) and their root associated soil microbes. Soybean plants were grown in a greenhouse for six
Seoungwoo Shin et al.
Molecules (Basel, Switzerland), 20(3), 3549-3564 (2015-02-24)
Glycation is an ageing reaction of naturally occurring sugars with dermal proteins, with clinical signs appearing in vivo around age 30, and increasing steadily/regularly with age. The suppleness of the dermis is affected by the formation of bridges between proteins
Yun Hu et al.
Nanoscale research letters, 9(1), 434-434 (2014-09-19)
Due to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact
Mohamad Sayed Abdellah et al.
European journal of obstetrics, gynecology, and reproductive biology, 165(2), 280-283 (2012-07-31)
The aim of the trial was to assess the safety and efficacy of tricholoroacetic acid for the treatment of dysfunctional uterine bleeding using topical versus intrauterine instillation. In a pilot prospective randomized clinical trial, seventy women were randomly allocated to
Mohammad T Jafari et al.
Analytica chimica acta, 853, 460-468 (2014-12-04)
The capability of electrospray ionization-conventional ion mobility spectrometry (ESI-IMS) for direct analysis of the samples extracted by solid phase microextraction (SPME) was investigated and evaluated for the first time. To that end, an appropriate new desorption chamber was designed and
Chih-Jung Yao et al.
Integrative cancer therapies, 13(6), 541-554 (2014-11-02)
High-grade gliomas are the most common and invasive malignant brain tumors in adults, and they are almost universally fatal because of drug resistance and recurrence. In spite of the progress in adjuvant therapy (like temozolomide) and irradiation after surgery, no
Mahmoud H El-Komy
The plant pathology journal, 30(4), 355-366 (2014-12-17)
In this study, resistance responses were investigated during the interaction of Botrytis fabae with two faba bean cultivars expressing different levels of resistance against this pathogen, Nubaria (resistant) and Giza 40 (susceptible). Disease severity was assessed on leaves using a
Leobardo Manuel Gómez-Oliván et al.
Environmental monitoring and assessment, 186(11), 7259-7271 (2014-07-10)
Toxicity in natural ecosystems is usually not due to exposure to a single substance, but is rather the result of exposure to mixtures of toxic substances. Knowing the effects of contaminants as a mixture compared to their effects in isolated
Alak Manna et al.
Anti-cancer agents in medicinal chemistry, 15(9), 1156-1163 (2015-06-03)
Multidrug resistance (MDR) refers to cross-resistance to a range of structurally and functionally unrelated compounds, and is accompanied by an elevated expression of ATP driven cell-membrane transporters. The cytotoxicity of Malabaricone-A (MAL-A), a diarylnonanoid derived from Myristica malabarica was demonstrated
Milena E Miska et al.
Rapid communications in mass spectrometry : RCM, 29(24), 2341-2348 (2015-11-14)
The environmental occurrence of chlorinated acetic acids (CAAs) has been extensively studied, but the sources and transport are still not yet fully understood. A promising approach for source apportionment and process studies is the isotopic characterization of target compounds. We
Alan Mortensen et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 55-62 (2012-10-17)
The ratio of the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH(4)) to its oxidized form dihydrobiopterin (BH(2)) has been suggested as an index of endothelial dysfunction. Consequently, much effort has been put into preserving the in vivo equilibrium between these
Shintaro Sugahara et al.
Journal of food science, 80(11), C2420-C2429 (2015-10-13)
Yacon (Smallanthus sonchifolius), a native Andean plant, has been cultivated as a crop and locally used as a traditional folk medicine for the people suffering from diabetes and digestive/renal disorders. However, the medicinal properties of this plant and its processed
Weerachat Sompong et al.
PloS one, 10(6), e0129495-e0129495 (2015-06-09)
Ferulic acid (FA) is the ubiquitous phytochemical phenolic derivative of cinnamic acid. Experimental studies in diabetic models demonstrate that FA possesses multiple mechanisms of action associated with anti-hyperglycemic activity. The mechanism by which FA prevents diabetes-associated vascular damages remains unknown.
Said Aoufouchi et al.
Molecular and cellular biology, 35(17), 3059-3070 (2015-07-01)
Mice derived from the 129 strain have a nonsense codon mutation in exon 2 of the polymerase iota (Polι) gene and are therefore considered Polι deficient. When we amplified Polι mRNA from 129/SvJ or 129/Ola testes, only a small fraction
Jayanta Kumar Patra et al.
Molecules (Basel, Switzerland), 20(3), 3986-4006 (2015-03-05)
In the present study, sawdust bio-oil (SBO) manufactured by fast pyrolysis of Japanese red pine (Pinus densiflora Siebold and Zucc.) sawdust was analyzed for its volatile chemical compound composition and evaluated for its free radical scavenging potential, inhibition of lipid
Ademola Adetokunbo Oyagbemi et al.
Environmental toxicology, 30(11), 1235-1243 (2014-04-08)
Removal of lead from the environment of man or otherwise, the movement of man from lead-contaminated areas has been employed as a means of abatement of the toxic effects of lead. Whether toxic effects in already-exposed individuals subside after lead
Samina Akhter et al.
BioMed research international, 2015, 356729-356729 (2015-07-30)
This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as
Ralf P Friedrich et al.
International journal of nanomedicine, 10, 4185-4201 (2015-07-15)
Due to their special physicochemical properties, iron nanoparticles offer new promising possibilities for biomedical applications. For bench to bedside translation of super-paramagnetic iron oxide nanoparticles (SPIONs), safety issues have to be comprehensively clarified. To understand concentration-dependent nanoparticle-mediated toxicity, the exact
Eli J Cohen et al.
Journal of bacteriology, 196(13), 2387-2395 (2014-04-22)
In Salmonella, the rod substructure of the flagellum is a periplasmic driveshaft that couples the torque generated by the basal body motor to the extracellular hook and filament. The rod subunits self-assemble, spanning the periplasmic space and stopping at the
Midori Suenaga et al.
Biochimica et biophysica acta, 1854(8), 1010-1018 (2015-05-10)
Impaired clearance of soluble Aβ (amyloid-β) promotes Aβ aggregation in brains with Alzheimer's disease (AD), while apolipoprotein-E (ApoE) in microglia mediates Aβ clearance. We studied the protease responsible for ApoE(4) degradation in human peripheral monocyte extracts, which are from the
V Arjunan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 625-638 (2012-08-04)
The structural investigations of the molecular complex of 2-methyl-4-nitroaniline with trichloroacetic acid, namely 2-methyl-4-nitroanilinium trichloroacetate trichloroacetic acid (C(11)H(10)Cl(6)N(2)O(6)) have been performed by means of single crystal and powder X-ray diffraction method. The complex was formed with accompanying proton transfer from
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