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Limei Chang et al.
Plant physiology, 169(2), 1127-1140 (2015-08-25)
Transcriptome resources for the medicinal plant Glaucium flavum were searched for orthologs showing identity with characterized O-methyltransferases (OMTs) involved in benzylisoquinoline alkaloid biosynthesis. Seven recombinant proteins were functionally tested using the signature alkaloid substrates for six OMTs: norlaudanosoline 6-OMT, 6-O-methyllaudanosoline
Shuai Zhang et al.
Analytical and bioanalytical chemistry, 407(30), 8971-8977 (2015-10-03)
Reliably detecting nitrofurazone (NFZ) residues in farmed crab and shrimp was previously hindered by lack of appropriately specific analytical methodology. Parent NFZ rapidly breaks down in meat, and the commonly used side-chain metabolite, semicarbazide (SEM), is non-specific as it occurs
Yueping Bao et al.
Chemosphere, 134, 550-556 (2015-01-07)
A systematic study on photolysis of tetrabromobisphenol A (2,2',6,6'-tetrabromo-4,4'-isopropylidendiphenol, TBBPA) in water was investigated under simulated sunlight irradiation. The results showed that the photolysis of TBBPA followed apparent pseudo-first-order kinetics. The photolysis rate constants (k) changed from 2.80 × 10(-2)
Elena Brezina et al.
Environmental science & technology, 49(17), 10449-10456 (2015-08-25)
Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHCBZ), 2-hydroxycarbamazepine (2OHCBZ), and 3-hydroxycarbamazepine (3OHCBZ). 2OHCBZ and 3OHCBZ were previously detected in raw and treated
Takeshi Fukushima et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(4), 669-677 (2015-04-09)
We previously developed a chelating ligand, 1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone (HMB-ASH), which can chelate Fe(III) to form a complex. The HMB-ASH-Fe(III) complex exhibits a dose-dependent anti-proliferative effect in HepG2 cells, whereas the ligand, HMB-ASH, and Fe(III) alone had no considerable effect. The HMB-ASH-Fe(III)
Nicholas J Martin et al.
Journal of the American Society for Mass Spectrometry, 26(8), 1320-1327 (2015-05-21)
Liquid extraction surface analysis (LESA) mass spectrometry is a promising tool for the analysis of intact proteins from biological substrates. Here, we demonstrate native LESA mass spectrometry of noncovalent protein complexes of myoglobin and hemoglobin from a range of surfaces.
Jinyeong Kim et al.
Protein expression and purification, 116, 90-97 (2015-08-16)
A novel gene encoding a thermostable esterase (designated as Est-gela) was isolated from the moderate thermophile Bacillus gelatini KACC 12197. The open reading frame of this gene (1170 bp) encodes 389 amino acid residues, and the molecular weight of Est-gela
Peilin Yang et al.
Journal of separation science, 38(13), 2253-2259 (2015-04-25)
Organic acids with very low pKa require extremely low pH conditions to achieve adequate retention in reversed-phase liquid chromatography, but an extremely low pH mobile phase can cause instrument reliability problems and limit the choice of columns. Hydrophilic interaction chromatography
S U Wetzels et al.
Journal of dairy science, 98(8), 5572-5587 (2015-06-09)
Ecological balance in the rumen is highly sensitive to concentrate-rich diets. Yet the effects of these feeding practices on the caprine bacterial epimural microbiome (CBEM), a microbial community with putative important physiological functions in the rumen, are largely unexplored. This
Tina Kamčeva et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 212-220 (2015-08-19)
Quantification of endogenous nucleotides is of interest for investigation of numerous cellular biochemical processes, such as energy metabolism and signal transduction, and may also be applied in cancer and antiretroviral therapies in which nucleoside analogues are used. For these purposes
Maria T Hultman et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 233-244 (2015-01-07)
Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to poor reproducibility, sensitivity and overall
Swen Langer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 73-81 (2014-05-06)
Water-soluble vitamins are an important class of compounds that require quantification from food sources to monitor nutritional value. In this study we have analysed six water-soluble B vitamins ([thiamine (B1), riboflavin (B2), nicotinic acid (B3, NAc), nicotinamide (B3, NAm), pyridoxal
M Grégoire et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 1-9 (2014-09-28)
A liquid chromatography-tandem mass spectrometry assay requiring a 100μL aliquot of human plasma for simultaneous determination of rilpivirine, a second generation non-nucleoside reverse transcriptase inhibitors of HIV and dolutegravir, a novel integrase stand transfer inhibitors of HIV concentrations has been
Dominic J Hare et al.
ACS chemical neuroscience, 6(3), 398-402 (2015-01-15)
Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used
J Y Liew et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(3), 274-279 (2015-02-03)
To investigate the association between vitamin D levels, angiographic severity of coronary artery disease, arterial stiffness and degree of peripheral arterial disease (PAD) as assessed by ankle brachial index (ABI). 375 patients undergoing coronary angiography from November 2012 to September
Walid M Ebeid et al.
Analytical and bioanalytical chemistry, 406(26), 6701-6712 (2014-09-06)
A RP-LC method was developed and validated for simultaneous determination of the active components, azilsartan medoxomil (AZL) and chlorthalidone (CLT), in their novel antihypertensive combined recipe. The chromatographic separation was achieved on an Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column using a mobile
Danilo Donnarumma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2260-2267 (2015-02-26)
Bexsero, a new vaccine against Neisseria meningitidis serogroup B (MenB), is composed of 3 main recombinant proteins and an outer membrane vesicle component. One of the main bactericidal antigens, neisseria heparin binding antigen (NHBA), is present as a fusion protein
Alberto Sánchez-Guijo et al.
Journal of lipid research, 56(2), 403-412 (2014-12-17)
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing
Sridhar Veeraraghavan et al.
Journal of pharmaceutical and biomedical analysis, 94, 125-131 (2014-02-25)
Efficacy assessments using a combination of ruxolitinib and nilotinib necessitate the development of a high precision analytical method for determination of both drugs in plasma. A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination
Andrew C Harris et al.
Drug and alcohol dependence, 147, 60-67 (2015-01-07)
Preclinical models are needed to inform regulation of tobacco products by the Food and Drug Administration (FDA). Typically, animal models of tobacco addiction involve exposure to nicotine alone or nicotine combined with isolated tobacco constituents (e.g. minor alkaloids). The goal
Fabrice Gritti et al.
Journal of chromatography. A, 1376, 112-125 (2014-12-30)
We propose an original model of effective diffusion along packed beds of mesoporous particles for HILIC developed by combining Torquatos model for heterogeneous beds (external eluent+particles), Landauers model for porous particles (solid skeleton+internal eluent), and the time-averaged model for the
Marc D Normandin et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(8), 1313-1322 (2015-04-03)
The Radiotracer [(11)C]OMAR was developed for positron emission tomography (PET) imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to evaluate kinetic analysis methods, determine test-retest reliability, and assess gender differences in receptor availability. Dynamic PET
Takashi Osawa et al.
Clinical biochemistry, 47(15), 54-59 (2014-07-11)
Pharmacokinetic disposition of bortezomib in the blood has not been fully characterized in humans. This study aimed to evaluate the blood distribution of bortezomib and its kinetics in multiple myeloma patients. Eighteen multiple myeloma patients receiving bortezomib-dexamethasone combination therapy were
Ute Linz et al.
Anti-cancer drugs, 26(7), 728-736 (2015-04-29)
In vitro, treosulfan (TREO) has shown high effectiveness against malignant gliomas. However, a first clinical trial for newly diagnosed glioblastoma did not show any positive effect. Even though dosing and timing might have been the reasons for this failure, it
V Hanot et al.
Journal of chromatography. A, 1384, 53-66 (2015-02-11)
In 2004, a new multi-residue pesticides method had been published using methanol as extraction solvent. Our goal for this study was to optimize the analytical scheme while extending the compound scope from 19 to 200 pesticides. The main changes from
Rozanna Avagyan et al.
Analytical and bioanalytical chemistry, 407(16), 4523-4534 (2015-05-04)
A simple and fast method for analysis of hydroxylated polycyclic aromatic hydrocarbons using pressurized liquid extraction and high performance liquid chromatography utilizing photoionization tandem mass spectrometry was developed. Simultaneous separation and determination of nine hydroxylated polycyclic aromatic hydrocarbons and two
Clara Coscollà et al.
Journal of chromatography. A, 1368, 132-142 (2014-10-15)
A comprehensive strategy for the analysis of current airborne pesticides has been developed using liquid chromatography coupled to high resolution mass spectrometry. The methodology includes both quantitative target analysis and post-run target screening analysis. The quantitative method was validated after
Vendula Pernikářová et al.
Journal of proteomics, 125, 68-75 (2015-05-16)
FerB is a cytoplasmic flavoprotein from the soil bacterium Paracoccus denitrificans with a putative role in defense against oxidative stress. To further explore this hypothesis, we compared protein variations upon methyl viologen treatment in wild-type and FerB mutant strains by
Ravi Rapolu et al.
Journal of pharmaceutical and biomedical analysis, 99, 59-66 (2014-07-30)
Forced degradation of Amlodipine Besylate (AMD) in acidic condition gave rise to a potential unknown impurity. This unknown acid degradation product (ADP) was evaluated using a new-reverse-phase high performance liquid chromatography (HPLC), where it was eluted at 1.24 relative retention
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