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Jingyu Guo et al.
Toxicology letters, 234(3), 201-210 (2015-03-01)
Metastasis is the leading cause of deaths in patients with breast cancer. Benzo[a]pyrene is a cumulative carcinogen and ubiquitous environmental pollutant with potent carcinogenic properties. As we report here, we established an accumulative mouse model mimicking the cumulative effects of...
Alessandro Ghezzo et al.
PloS one, 9(11), e113111-e113111 (2014-11-25)
Down Syndrome (DS) is characterised by premature aging and an accelerated decline of cognitive functions in the vast majority of cases. As the life expectancy of DS persons is rapidly increasing, this decline is becoming a dramatic health problem. The...
Ekhtear Hossain et al.
Toxicology and applied pharmacology, 273(3), 651-658 (2013-10-23)
Although chronic arsenic exposure is a well-known risk factor for cardiovascular diseases, including atherosclerosis, the molecular mechanism underlying arsenic-induced atherosclerosis remains obscure. Therefore, this study aimed to elucidate this molecular mechanism. We examined changes in the mRNA level of the...
Elaine Gutierrez et al.
The Journal of biological chemistry, 289(48), 33568-33589 (2014-10-11)
Autophagy functions as a survival mechanism during cellular stress and contributes to resistance against anticancer agents. The selective antitumor and antimetastatic chelator di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) causes lysosomal membrane permeabilization and cell death. Considering the integral role of lysosomes in autophagy...
Haibo Chen et al.
Apoptosis : an international journal on programmed cell death, 19(12), 1712-1726 (2014-10-25)
Ultrasound combined with endogenous protoporphyrin IX derived from 5-aminolevulinic acid (ALA-SDT) is known to induce apoptosis in multiple cancer cells and macrophages. Persistent retention of macrophages in the plaque has been implicated in the pathophysiology and progression of atherosclerosis. Here...
Yang Zhou et al.
Antonie van Leeuwenhoek, 108(1), 163-171 (2015-05-20)
Mycobacterium bovis is the causative agent of tuberculosis in cattle. Infection of macrophages with M. bovis leads to the activation of the "nucleotide binding and oligomerization, leucine-rich repeat and pyrin domains-containing protein 3" (NLRP3) and "absent in melanoma 2" (AIM2)...
Ting Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1942-1953 (2014-07-09)
The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myeloid-derived suppressor cells (MDSCs) in multiple organs and subsequent inflammation remain incompletely understood. Endothelial cells (ECs), lining the inner layer of blood vessels, constitute barriers regulating leukocytes transmigration...
N-Acetylcysteine Protection in COPD: An Alternative Mechanism of Action.
Wenxin Wu et al.
Chest, 145(1), 193-194 (2014-01-08)
Chenran Wang et al.
Nature neuroscience, 16(5), 532-542 (2013-04-02)
Despite recent studies showing that inhibition of autophagy depletes the hematopoietic stem cell pool and increases intracellular reactive oxygen species (ROS), it remains unknown whether autophagy is essential in the maintenance of other stem cells. Moreover, it is unclear whether...
Cheryl A Conover et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 18(3), 213-220 (2007-10-16)
Pregnancy-associated plasma protein-A (PAPP-A), a metalloproteinase that serves to modulate local insulin-like growth factor (IGF) action, is upregulated in atherosclerotic plaque. However, little is known about the cellular mechanisms underlying this elevated PAPP-A. To continue study of PAPP-A expression and...
Yiwei Li et al.
Cell stem cell, 28(1), 63-78 (2020-10-15)
Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-sized cellular space. However, the significance of the physical properties of cells remains underappreciated because of a lack of evidence of how they affect cellular functionalities. Here, we show that...
Jie Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 196-208 (2014-10-22)
Excess accumulation of endogenous all-trans-retinal (atRAL) contributes to degeneration of the retinal pigment epithelium (RPE) and photoreceptor cells, and plays a role in the etiologies of age-related macular degeneration (AMD) and Stargardt's disease. In this study, we reveal that human...
Miao Wang et al.
Cancer research, 75(23), 5058-5069 (2015-11-19)
Elevated oxidative stress is an aberration seen in many solid tumors, and exploiting this biochemical difference has the potential to enhance the efficacy of anticancer agents. Homeostasis of reactive oxygen species (ROS) is important for normal cell function, but excessive...
Marcelo G Binker et al.
Biochemical and biophysical research communications, 463(4), 1047-1052 (2015-06-17)
Chronic obstructive pulmonary disease (COPD) is an inflammatory process characterized by airway mucus hypersecretion. Lipopolysaccharides (LPS) are known to stimulate the production of mucin 5AC (MUC5AC) via epidermal growth factor receptor (EGFR) in human airway cells. Noteworthy, we have previously...
Eun Chul Kim et al.
Experimental eye research, 127, 20-25 (2014-06-22)
The present study evaluated survival effects of N-acetylcysteine (NAC) on cultured corneal endothelial cells exposed to oxidative and endoplasmic reticulum (ER) stress and in a mouse model of early-onset Fuchs endothelial corneal dystrophy (FECD). Cultured bovine corneal endothelial cell viability...
Grace Chen et al.
Blood, 123(24), 3818-3827 (2014-03-13)
Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis with elevated cell-free hemoglobin and heme. The ensuing depletion of heme scavenger proteins...
Atsushi Sasaki et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 568-575 (2014-09-18)
Peripheral postischemic dysesthesia was examined behaviorally in mice and we investigated the underlying molecular mechanism with a focus on oxidative stress. Hind-paw ischemia was induced by tight compression of the ankle with a rubber band, and reperfusion was achieved by...
Nina Bertaux-Skeirik et al.
PLoS pathogens, 11(2), e1004663-e1004663 (2015-02-07)
The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA translocates into the cytoplasm where it stimulates cell signaling through the interaction with tyrosine kinase c-Met receptor, leading cellular proliferation....
Xu Li et al.
Cancer letters, 357(1), 219-230 (2014-12-03)
Application of oxaliplatin for the treatment of pancreatic cancer (PC) is restricted owing to its toxic side effects and drug resistance. We investigated how withaferin A (WA), a bioactive component isolated from the medicinal plant Withania somnifera, acts synergistically with...
Takaaki Miyake et al.
International journal of oncology, 47(1), 315-324 (2015-05-06)
Although progress has been made in chemotherapeutic strategies against pancreatic cancer, overall survival has not significantly improved over the past decade. Thus, the development of better therapeutic regimens remains a high priority. Pancreatic cancer cell lines were treated with tamoxifen...
Karim H Shalaby et al.
Journal of immunology (Baltimore, Md. : 1950), 191(2), 922-933 (2013-06-19)
Oxidative stress in allergic asthma may result from oxidase activity or proinflammatory molecules in pollens. Signaling via TLR4 and its adaptor Toll-IL-1R domain-containing adapter inducing IFN-β (TRIF) has been implicated in reactive oxygen species-mediated acute lung injury and in Th2...
Sandeep Kumar Dash et al.
Journal of applied toxicology : JAT, 34(11), 1130-1144 (2014-01-31)
The aim of the present study was to develop zinc sulfide nanoparticles (ZnS NPs) and to study their cytotoxicity against the KG-1A (human acute myeloid leukemia) cell line. ZnS NPs were synthesized using the pyrolytic method and characterized by X-ray...
Karthyayani Rajamani et al.
Cell transplantation, 24(3), 493-507 (2015-02-06)
As assuring cell quality is an essential parameter for the success of stem cell therapy, the impact of various senescence-inducing stress signals, and strategies to circumvent them, has been an important area of focus in stem cell research. The aim...
Anna Urciuolo et al.
Nature biomedical engineering, 4(9), 901-915 (2020-06-24)
Fabrication of three-dimensional (3D) structures and functional tissues directly in live animals would enable minimally invasive surgical techniques for organ repair or reconstruction. Here, we show that 3D cell-laden photosensitive polymer hydrogels can be bioprinted across and within tissues of...
M Hossein Aghdaie et al.
International journal of organ transplantation medicine, 11(1), 15-25 (2020-12-17)
Hepatocyte transplantation using isolated human hepatocytes is an alternative source that can be used for the treatment of metabolic diseases and acute liver failure as a time bridge to liver transplantation. These cells can also be used for bioartificial liver...
Kennon Heard et al.
Current pharmaceutical biotechnology, 13(10), 1917-1923 (2012-02-23)
Acetylcysteine has been used to treat acetaminophen overdose for nearly 50 years. While no placebo controlled trials have been conducted, the efficacy of acetylcysteine is accepted for the prevention of hepatic injury when administered early after acetaminophen overdose. Acetylcysteine can...
Danielle B Ulanet et al.
PloS one, 9(12), e115144-e115144 (2014-12-17)
Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the gene is not known...
Valentina Sica et al.
Cell reports, 27(3), 820-834 (2019-04-18)
Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor, fails to kill human cancer cells in vitro. Driven by this consideration, we attempted to identify agents that engage in synthetically lethal interactions with B87. Here, we...
Owen Clark et al.
Cancer letters, 357(1), 316-327 (2014-12-03)
In a wide range of neuroblastoma-derived lines oxovanadium compounds such as bis(maltolato)oxovanadium(IV) (BMOV) are cytotoxic. This is not explained by oxidative stress or inhibition of ion channels. Genotoxicity is unlikely given that a p53 response is absent and p53-mutant lines...
Christie McCracken et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1793-1808 (2015-07-22)
Given the increasing use of silver nanoparticles (Ag NP) by the food and food packaging industries, this study investigated potential consequences of Ag NP ingestion in intestinal epithelial C2BBe1 cells. Treatment of proliferating cells (<10,000 cells/cm(2)) with 0.25 μg/cm(2) (1.25...
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