Showing 1-24 of 24 resultados for "AB9272"
Stephanie W Fowler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(23), 7871-7885 (2014-06-06)
An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD...
Meng-Hsuan Han et al.
Molecular & cellular proteomics : MCP, 12(12), 3719-3731 (2013-09-12)
The cysteine protease caspase-3, best known as an executioner of cell death in apoptosis, also plays a non-apoptotic role in N-methyl-d-aspartate receptor-dependent long-term depression of synaptic transmission (NMDAR-LTD) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor endocytosis in neurons. The mechanism by which...
Eduardo Penna et al.
Frontiers in molecular neuroscience, 12, 195-195 (2019-08-31)
Cystatin B (CSTB) is a ubiquitous protein belonging to a superfamily of protease inhibitors. CSTB may play a critical role in brain physiology because its mutations cause progressive myoclonic epilepsy-1A (EPM1A), the most common form of progressive myoclonic epilepsy. However...
Scott D Z Eggers et al.
PloS one, 10(7), e0132075-e0132075 (2015-07-03)
Perineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role. Within the ocular motor system, excitatory...
Angie C A Chiang et al.
The Journal of experimental medicine, 215(5), 1349-1364 (2018-04-08)
Drug development for Alzheimer's disease has endeavored to lower amyloid β (Aβ) by either blocking production or promoting clearance. The benefit of combining these approaches has been examined in mouse models and shown to improve pathological measures of disease over...
Natividade de Sá Couto-Pereira et al.
Frontiers in molecular neuroscience, 12, 134-134 (2019-06-14)
Early life experiences program lifelong responses to stress. In agreement, resilience and vulnerability to psychopathologies, such as posttraumatic stress disorder (PTSD), have been suggested to depend on the early background. New therapies have targeted memory reconsolidation as a strategy to...
Patty C Kandalepas et al.
Acta neuropathologica, 126(3), 329-352 (2013-07-04)
β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are increased in AD, which could contribute to pathogenesis, yet the mechanism of BACE1 elevation is unclear. Furthermore, the...
Stuart D Portbury et al.
Journal of Alzheimer's disease : JAD, 60(2), 549-560 (2017-09-05)
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a...
Yongfang Chen et al.
Environmental toxicology, 31(12), 1720-1730 (2015-07-29)
The objective of this study is to understand the impairment of learning and memory in mouse after chronic nitrite exposure. The animal model of nitrite exposure in mouse was created with the daily intubation of nitrite in adult healthy male...
Luisa Speranza et al.
Journal of neurochemistry, 141(5), 647-661 (2017-01-26)
Precise control of dendritic spine density and synapse formation is critical for normal and pathological brain functions. Therefore, signaling pathways influencing dendrite outgrowth and remodeling remain a subject of extensive investigations. Here, we report that prolonged activation of the serotonin...
Stuart D Portbury et al.
PloS one, 12(8), e0183683-e0183683 (2017-08-25)
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which there are currently no effective pharmacological treatment options. In this study then, we utilized a mouse model of TBI to assess the therapeutic potential of...
Qing Yu et al.
Journal of Alzheimer's disease : JAD, 59(1), 223-239 (2017-06-10)
Loss of synapse and synaptic dysfunction contribute importantly to cognitive impairment in Alzheimer's disease (AD). Mitochondrial dysfunction and oxidative stress are early pathological features in AD-affected brain. However, the effect of AD mitochondria on synaptogenesis remains to be determined. Using...
Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease.
Camboni, M; Wang, CM; Miranda, C; Yoon, JH; Xu, R; Zygmunt, D; Kaspar, BK; Martin, PT
Neurobiology of Disease null
Ji-Yoen Kim et al.
Human molecular genetics, 25(21), 4661-4673 (2017-02-09)
Four mutations in the VAMP/synaptobrevin-associated protein B (VAPB) gene have been linked to amyotrophic lateral sclerosis (ALS) type 8. The mechanism by which VAPB mutations cause motor neuron disease is unclear, but studies of the most common P56S variant suggest...
Stephen W Scheff et al.
Journal of Alzheimer's disease : JAD, 43(3), 1073-1090 (2014-08-26)
Mild cognitive impairment (MCI) is considered to be an early stage in the progression of Alzheimer's disease (AD) providing an opportunity to investigate brain pathogenesis prior to the onset of dementia. Neuroimaging studies have identified the posterior cingulate gyrus (PostC)...
Owen Clark et al.
Cancer letters, 357(1), 316-327 (2014-12-03)
In a wide range of neuroblastoma-derived lines oxovanadium compounds such as bis(maltolato)oxovanadium(IV) (BMOV) are cytotoxic. This is not explained by oxidative stress or inhibition of ion channels. Genotoxicity is unlikely given that a p53 response is absent and p53-mutant lines...
Rachel A Cliburn et al.
Journal of chemical neuroanatomy, 83-84, 82-90 (2016-11-12)
Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. VMAT2 function and related vesicle dynamics have been linked to susceptibility...
Jie-Min Jia et al.
Nature neuroscience, 16(11), 1627-1636 (2013-10-15)
Dopamine D2 receptors (D2R) are G protein-coupled receptors that modulate synaptic transmission and are important for various brain functions, including learning and working memory. Abnormal D2R signaling has been implicated in psychiatric disorders such as schizophrenia. Here we report a...
Adele Woodhouse et al.
BMC anesthesiology, 18(1), 47-47 (2018-04-28)
There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer's disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate...
Marcus Dyer et al.
Frontiers in aging neuroscience, 11, 68-68 (2019-04-20)
There is increasing interest in the role of epigenetic alterations in Alzheimer's disease (AD). The epigenome of every cell type is distinct, yet data regarding epigenetic change in specific cell types in aging and AD is limited. We investigated histone...
Dieter Janzen et al.
Advanced healthcare materials, 9(9), e1901630-e1901630 (2020-03-18)
Impairments in neuronal circuits underly multiple neurodevelopmental and neurodegenerative disorders. 3D cell culture models enhance the complexity of in vitro systems and provide a microenvironment closer to the native situation than with 2D cultures. Such novel model systems will allow...
GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.
Fiorentino, H; Kuczewski, N; Diabira, D; Ferrand, N; Pangalos, MN; Porcher, C; Gaiarsa, JL
The Journal of Neuroscience null
Rachel Comba et al.
F1000Research, 4, 396-396 (2016-03-01)
Improvement on spatial tasks is observed during a late, postnatal developmental period (PND18 - PND24).  The purpose of the current work was 1) to determine whether the emergence of spatial-behavioral function was based on the ability to generate appropriate behavioral...
Goran Tomic et al.
Cell stem cell, 23(3), 436-443 (2018-08-14)
The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently committed progenitors also contributing, particularly following tissue damage. However, the mechanism of, and requirement for, progenitor plasticity in mediating pathological response remain unknown. Here we show that phosphorylation...

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