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Stefan Allmann et al.
The Journal of biological chemistry, 288(25), 18494-18505 (2013-05-15)
All living organisms depend on NADPH production to feed essential biosyntheses and for oxidative stress defense. Protozoan parasites such as the sleeping sickness pathogen Trypanosoma brucei adapt to different host environments, carbon sources, and oxidative stresses during their infectious life
Yun-shang Piao et al.
The Journal of steroid biochemistry and molecular biology, 138, 206-213 (2013-06-19)
The inflammatory tissue microenvironment can be an active promoter in preneoplastic cancer lesions. Altered steroid hormone metabolism as induced by the inflammatory microenvironment may contribute to epithelial cancer progression. Dehydroepiandrosterone sulfate (DHEAS) is the most abundant endogenous steroid hormone present
Fumio Ishizaki et al.
Scientific reports, 3, 1528-1528 (2013-03-26)
Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally synthesized from the inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in prostate cancer cells via different pathways in a concentration-dependent
Ian Cook et al.
The Journal of biological chemistry, 288(12), 8619-8626 (2013-01-31)
Human cytosolic sulfotransferases (SULTs) regulate the activities of hundreds of signaling metabolites via transfer of the sulfuryl moiety (-SO3) from activated sulfate (3'-phosphoadenosine 5'-phosphosulfate) to the hydroxyls and primary amines of xeno- and endobiotics. How SULTs select substrates from the
Murat Oz et al.
Archives of gynecology and obstetrics, 290(1), 131-134 (2014-02-04)
Ovarian steroid cell tumors are very rare sex cord-stromal tumors, and most of them are unilateral and almost one-third of the cases are malignant. Here, we present a pregnant woman, who diagnosed with steroid cell tumor of the ovary and
Vasileia Anagnostopoulou et al.
Endocrinology, 154(7), 2446-2456 (2013-05-23)
Tumor growth is fostered by inhibition of cell death, which involves the receptiveness of tumor to growth factors and hormones. We have recently shown that testosterone exerts proapoptotic effects in prostate and colon cancer cells through a membrane-initiated mechanism. In
Tracy Wing Yee Yeung et al.
Fertility and sterility, 102(1), 108-115 (2014-05-07)
To evaluate whether pretreatment dehydroepiandrosterone (DHEA) supplementation improves ovarian response markers, ovarian response to standard low-dose gonadotropin stimulation, and in vitro fertilization (IVF) outcomes in poor responders. Randomized, double-blind, placebo-controlled pilot study. Tertiary reproductive medicine unit. Thirty-two women with anticipated
Sophie Rettenbacher et al.
General and comparative endocrinology, 184, 67-74 (2013-01-22)
Glucocorticoids affect reproductive hormone production in many species. In chickens, elevated plasma corticosterone down-regulates testosterone and progesterone concentrations in plasma, but also in egg yolk. This suppression could be mediated via the hypothalamic-pituitary system but also via local inhibition of
E Borman et al.
Clinical and experimental obstetrics & gynecology, 39(4), 429-431 (2013-03-01)
To determine if in a population of women with diminished oocyte reserve as evidenced by day 3 serum follicle stimulating hormone (FSH) levels > 12 mIU/ml women with lower dehydroepiandrosterone sulfate (DHEA-s) levels produce fewer oocytes or have lower pregnancy
V A Gavrilova et al.
Bulletin of experimental biology and medicine, 154(1), 89-91 (2013-01-19)
We studied blood serum levels of neurosteroids, dehydroepiandrosterone and its sulfate, in individuals with personality disorders convicted of serious violent crimes. The data were compared with that of a group of mentally and physically healthy persons convicted of acquisitive crimes
Julia Espinoza et al.
The Journal of steroid biochemistry and molecular biology, 138, 174-182 (2013-06-04)
Primates secrete large amounts of the precursor steroid dehydroepiandrosterone (DHEA); in humans, its levels are low during childhood and start declining after the fourth decade. It has been postulated that the progressive decline in DHEA levels may be related with
Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor.
Ales Belic et al.
Chemico-biological interactions, 203(3), 597-603 (2013-04-23)
The pharmacological dosage of dehydroepiandrosterone (DHEA) protects against chemically induced carcinogenesis. The chemoprotective activity of DHEA is attributed to its inhibitory potential for the expression of CYP1A enzymes, which are highly responsible for metabolic activation of several mutagenic and carcinogenic
Y T Konttinen et al.
The Journal of steroid biochemistry and molecular biology, 145, 237-244 (2014-08-27)
Sjögren's syndrome (SS) is an autoimmune disease characterized by lymphoplasmacytoid focal adenitis leading to mucosal dryness, with 9:1 female dominance and peak incidence at menopause. Due to autoimmune adenitis it can be speculated that the normal epithelial cell renewal has
Intracrinology in action: importance of extragonadal sex steroid biosynthesis and inactivation in peripheral tissues in both women and men.
Fernand Labrie
The Journal of steroid biochemistry and molecular biology, 145, 131-132 (2014-09-23)
Kenna Stephenson et al.
International journal of pharmaceutical compounding, 17(1), 74-85 (2013-05-01)
Menopause impacts 25 million women world wide each year, and the World Health Organization estimates 1.2 billion women will be postmenopausal by 2030. Menopause has been associated with symptoms of hot flashes, night sweats, dysphoric mood, sleep disturbance, and conditions
Juilee Rege et al.
The Journal of clinical endocrinology and metabolism, 98(3), 1182-1188 (2013-02-07)
A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid chromatography-tandem mass spectrometry to quantify 9 C19 steroids (androgens and their precursors), estrone, and estradiol in the adrenal vein
K Collomp et al.
The Journal of steroid biochemistry and molecular biology, 145, 206-212 (2014-04-08)
The dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) concentrations during acute and chronic exercise (training) have been investigated only fairly recently. DHEA is generally preferred to DHEA-S for exploring the acute exercise repercussions in laboratory or field tests because of its
T Søeborg et al.
Clinica chimica acta; international journal of clinical chemistry, 419, 95-101 (2013-03-05)
Diagnosis and management of infants and children with sex steroid disorders require fast and simultaneous assessment of several sex steroid metabolites in serum at low concentrations and on small sample volumes. Therefore, we developed a sensitive and selective TurboFlow-LC-MS/MS method
Kai Cai et al.
Biochimica et biophysica acta, 1841(4), 552-562 (2013-12-27)
Diacylglycerol kinase theta (DGKθ) plays a pivotal role in regulating adrenocortical steroidogenesis by synthesizing the ligand for the nuclear receptor steroidogenic factor 1 (SF1). In response to activation of the cAMP signaling cascade nuclear DGK activity is rapidly increased, facilitating
Mark O Goodarzi et al.
The Journal of steroid biochemistry and molecular biology, 145, 213-225 (2014-07-11)
Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although
Chun-Ju Lin et al.
Biochemical pharmacology, 90(3), 288-296 (2014-05-31)
Inhibition of 17α-hydroxylase/17,20-lyase (CYP17), which dictates the proceeding of androgen biosynthesis, is recommended as an effective treatment for androgen-dependent diseases. However, androgen depletion by selective CYP17 inhibition is accompanied with corticosteroid elevation, which increases risk of cardiovascular diseases. In this
Tiphaine Mannic et al.
Endocrinology, 154(3), 1271-1281 (2013-02-12)
Corticosteroids have been involved in the genesis of ventricular arrhythmias associated with pathological heart hypertrophy, although molecular mechanisms responsible for these effects have not been completely explained. Because mineralocorticoid receptor (MR) antagonists have been demonstrated to be beneficial on the
David F Archer
The Journal of steroid biochemistry and molecular biology, 145, 139-143 (2014-09-10)
The effects of intravaginal administration of dehydroepiandrosterone (DHEA) for the management of symptomatic vulvovaginal atrophy are reviewed. A literature search related to vulvovaginal atrophy, vaginal atrophy, atrophic vaginitis, estrogen, dehydroepiandrosterone, vulvar itching, burning, dryness, dyspareunia, and libido was performed. Relevant
Marcello Maggio et al.
The Journal of steroid biochemistry and molecular biology, 145, 281-292 (2014-05-06)
The adrenal prohormone dehydroepiandrosterone (DHEA) and its sulphate conjugate (DHEAS) steadily decrease with age by 10% per decade reaching a nadir after the age of 80. Both DHEA and DHEAS (DHEA/S) exert many biological activities in different tissues and organs.
Andreu Fabregat et al.
The Journal of steroid biochemistry and molecular biology, 139, 192-200 (2013-02-16)
Alterations in the maternal excretion of steroids during pregnancy are not restricted to the production of progesterone and estriol by the fetoplacental unit. Although there is a lack of longitudinal data on urinary androgen concentrations during pregnancy, some studies revealed
C Kamrath et al.
Klinische Padiatrie, 225(1), 3-7 (2013-01-19)
During the last year, alternative androgen synthesis pathways have been discovered in humans. This review article highlights these new concepts of androgen synthesis.We performed a selective literature research using PubMed.After the discovery of a new androgen synthesis pathway in marsupials
Declan Doherty et al.
The Prostate, 74(3), 273-285 (2013-11-19)
A contributing factor to the emergence of castrate resistant prostate cancer (CRPC) is the ability of the tumor to circumvent low circulating levels of testosterone during androgen deprivation therapy (ADT), through the production of "intracrine" tumoral androgens from precursors including
Yasuhiro Shibata et al.
The Journal of steroid biochemistry and molecular biology, 145, 193-199 (2014-05-06)
A reliable and sensitive method for analyzing steroids using liquid chromatography tandem mass spectrometry (LC-MS/MS) is required for research concerning dehydroepiandrosterone (DHEA), which plays a central role in steroid hormone biosynthesis and metabolism. Furthermore, after the first proposal of the
Heng Li et al.
Journal of industrial microbiology & biotechnology, 41(10), 1497-1504 (2014-08-26)
Dihydroxylation of dehydroepiandrosterone (DHEA) is an essential step in the synthesis of many important pharmaceutical intermediates. However, the solution to the problem of low biohydroxylation conversion in the biotransformation of DHEA has yet to be found. The effects of natural
H Bobby Fokidis et al.
Endocrinology, 154(11), 4328-4339 (2013-08-14)
Aggression enables individuals to obtain and retain limited resources. Studies of the neuroendocrine regulation of aggression have focused on territorial and reproductive contexts. By contrast, little is understood concerning the neuroendocrine regulation of aggression over other resources, such as food.
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