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Yi Cao et al.
Environmental toxicology and pharmacology, 40(1), 164-171 (2015-07-01)
Exposure to diesel exhaust particles (DEP) has been associated with adverse cardiopulmonary health effects, which may be related to dysregulation of lipid metabolism and formation of macrophage foam cells. In this study, THP-1 derived macrophages were exposed to an automobile...
Aline de Souza et al.
Drug delivery and translational research, 10(6), 1771-1787 (2020-08-26)
Peptide-mediated targeting to colorectal cancer can increase selectivity and specificity of this cancer diagnosis acting as biomarkers. The present work aimed to select peptides using the phage display technique and associate the peptides with polymeric nanospheres in order to evaluate...
Arne Homann et al.
Journal of translational medicine, 13, 339-339 (2015-10-30)
Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab. A common side effect of therapeutic antibodies is the induction of anti-drug antibodies, which may reduce therapeutic efficacy. In order to...
Whitney C Blocher McTigue et al.
Physical chemistry chemical physics : PCCP, 22(36), 20643-20657 (2020-09-09)
Complex coacervation has become a prominent area of research in the fields of food science, personal care, drug stabilization, and more. However, little has been reported on the kinetics of assembly of coacervation itself. Here, we describe a simple, low-cost...
Pavla Simerska et al.
Drug delivery and translational research, 4(3), 246-255 (2015-03-20)
Peptide-based vaccine delivery can be hampered by rapid peptidase activity and poor inherent immunogenicity. The self-adjuvanting lipid core peptide system (LCP) has been shown to confer improved stability and immunogenicity on peptide epitopes of group A Streptococcus, Chlamydia, hookworm, and...
Ayele H Negussie et al.
Journal of materials science. Materials in medicine, 26(6), 198-198 (2015-06-25)
Therapeutic embolization of blood vessels is a minimally invasive, catheter-based procedure performed with solid or liquid emboli to treat bleeding, vascular malformations, and vascular tumors. Hepatocellular carcinoma (HCC) affects about half a million people per year. When unresectable, HCC is...
Thierry Brun et al.
Human molecular genetics, 24(18), 5270-5284 (2015-07-01)
In pancreatic β-cells, mitochondria play a central role in coupling glucose metabolism to insulin secretion. Chronic exposure of β-cells to metabolic stresses impairs their function and potentially induces apoptosis. Little is known on mitochondrial adaptation to metabolic stresses, i.e. high...
Rohini Sidhu et al.
Journal of lipid research, 56(6), 1222-1233 (2015-04-14)
24(S)-hydroxycholesterol [24(S)-HC] is a cholesterol metabolite that is formed almost exclusively in the brain. The concentrations of 24(S)-HC in cerebrospinal fluid (CSF) and/or plasma might be a sensitive marker of altered cholesterol metabolism in the CNS. A highly sensitive 2D-LC-MS/MS...
Hiroyasu Tamura et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1191-1199 (2015-03-20)
In the brewing of high-quality sake such as Daiginjo-shu, the cerulenin-resistant sake yeast strains with high producing ability to the flavor component ethyl caproate have been used widely. Genetic stability of sake yeast would be important for the maintenance of...
Aurélien Tidu et al.
Acta biomaterialia, 22, 50-58 (2015-05-02)
Several diseases can lead to opacification of cornea requiring transplantation of donor tissue to restore vision. In this context, transparent collagen I fibrillated matrices have been synthesized at 15, 30, 60 and 90 mg/mL. The matrices were evaluated for fibril...
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents...
Colette M Smart et al.
Neuropsychology, 29(6), 971-987 (2015-05-27)
To ascertain whether the Iowa Gambling Task (IGT) could be used to detect and identify measurable cognitive differences between older adults with subjective cognitive decline (SCD) as compared with healthy older controls (HC). Older adults with self-identified SCD and age-matched...
Scott Boitano et al.
PloS one, 9(6), e99140-e99140 (2014-06-14)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to determine minimal...
Bin Zhu et al.
Antiviral research, 118, 29-38 (2015-03-24)
Infectious diseases of viral origin cause major aquatic production losses in different parts of the world. Because of formidable barriers for gastrointestinal tract, skin and cell, large amounts of antiviral drugs have limited therapeutic effect. In the current study, functionalized...
Valentina Marchesin et al.
The Journal of cell biology, 211(2), 339-358 (2015-10-28)
Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In...
Tianyi Zhang et al.
Journal of cell science, 128(15), 2938-2950 (2015-06-21)
The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we report that...
Paul W R Harris et al.
Biopolymers, 104(2), 116-127 (2015-02-07)
The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail...
Ye Zhang et al.
ACS applied materials & interfaces, 7(19), 10201-10212 (2015-05-06)
In this study, a biocompatible nanoplatform has been constructed on the basis of magnetic mesoporous silica nanoparticles (Fe3O4@mSiO2) via surface modification of triphenylphospine (TPP) and then conjugation with fluorescent carbon dots (CDs). The as-prepared Fe3O4@mSiO2-TPP/CDs nanoplatform shows a very low...
J S McMurray et al.
Peptide research, 7(4), 195-206 (1994-07-01)
Head-to-tail cyclization of peptides attached to insoluble supports by means of the side chains of aspartic acid or glutamic acid allows the rapid synthesis of cyclic peptides of widely varied amino acid sequence. However, two side reactions dramatically reduce the...
Tetrahedron Letters, 35, 5981-5981 (1994)
M Zouhair Atassi et al.
Journal of neuroimmunology, 272(1-2), 29-34 (2014-05-21)
In cervical dystonia, injection of botulinum neurotoxin (BoNT) A or B into affected neck muscle reduces symptoms but may elicit anti-toxin antibodies (Abs) that block responsiveness to treatment. Previously, we localized the BoNT/A and BoNT/B sites that bind mouse or...
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS...
Wei Tao et al.
Advanced healthcare materials, 4(8), 1203-1214 (2015-03-25)
A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide)...
Xikuang Yao et al.
Biomacromolecules, 16(7), 2059-2071 (2015-05-30)
Cisplatin-incorporating pseudoblock copolymer nanoparticles with high drug loading efficiency (ca. 50%) were prepared built on host-guest inclusion complexation between β-cyclodextrin end-capped poly(N-vinylpyrrolidone) block and admantyl end-capped poly(aspartic acid) block, followed by the coordination between cisplatin and carboxyl groups in poly(aspartic...
K L Witt et al.
Environmental and molecular mutagenesis, 33(1), 65-74 (1999-02-26)
The induction of micronucleated erythrocytes by diisopropylcarbodiimide (DIC) and dicyclohexylcarbodiimide (DCC) was investigated as part of a U.S. National Toxicology Program (NTP) evaluation of the subchronic toxicity of these chemicals. Analysis of peripheral blood smears from male and female B6C3F1...
Egan J Lohman et al.
Biotechnology for biofuels, 8, 82-82 (2015-06-24)
Large-scale algal biofuel production has been limited, among other factors, by the availability of inorganic carbon in the culture medium at concentrations higher than achievable with atmospheric CO2. Life cycle analyses have concluded that costs associated with supplying CO2 to...
Kiley L Yeakel et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14512-14517 (2015-11-11)
Oceanic uptake of anthropogenic carbon dioxide (CO2) has acidified open-ocean surface waters by 0.1 pH units since preindustrial times. Despite unequivocal evidence of ocean acidification (OA) via open-ocean measurements for the past several decades, it has yet to be documented...
J Izdebski et al.
Journal of peptide science : an official publication of the European Peptide Society, 3(2), 141-144 (1997-03-01)
A competitive reaction of activated Boc-Ala-OH and Boc-Phe-OH with H-Leu-resin has been developed for assessing the relative efficiencies of different carbodiimides. This allowed a comparison of the efficiency of the carbodiimides N,N'-dicyclohexylcarbodiimide,N,N'-diisopropylcarbodiimide, N-tert-butyl-N'-methylcarbodiimide and N-tert-butyl-N'-ethylcarbodiimide. Comparable results were obtained when...
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Hyo-Eon Jin et al.
Nano letters, 15(11), 7697-7703 (2015-10-13)
We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominated frame retardants (polybrominated diphenyl ether (PBDE)), using newly discovered DBDE peptide...
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