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D6750

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Melinda A Brindley et al.
Journal of virology, 89(2), 1230-1241 (2014-11-14)
Measles virus (MeV), a morbillivirus within the paramyxovirus family, expresses two envelope glycoproteins. The attachment (H) protein mediates receptor binding, followed by triggering of the fusion (F) protein, which leads to merger of the viral envelope with target cell membranes....
Fanny Ehret et al.
Neurobiology of disease, 75, 131-141 (2015-01-04)
Could impaired adult hippocampal neurogenesis be a relevant mechanism underlying CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)? Memory symptoms in CADASIL, the most common hereditary form of vascular dementia, are usually thought to be primarily due to...
Yohei Hirano et al.
Critical care (London, England), 19, 53-53 (2015-04-19)
Sepsis refers to severe systemic inflammation leading to acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by immune reactive cells, plays a deleterious role in various inflammatory...
Silvia Baiguera et al.
Biomaterials, 35(24), 6344-6350 (2014-05-14)
Decellularized tissues and organs represent a suitable option for tissue engineering when specific scaffolds are needed. However, the optimal conditions to completely remove all the cellular components and minimally affect the biochemical and structural properties of the extracellular matrix are...
Daniela Surico et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(6), 2108-2120 (2015-08-19)
Previous reports have made it hypothetically possible that human chorionic gonadotropin (hCG) could protect against the onset of pregnancy-related pathological conditions by acting as an antioxidant. In the present study we planned to examine the effects of hCG against oxidative...
Yi-Ming Yuan et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(2), 249-253 (2015-03-22)
To explore the role of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of pulmonary arterial hypertension (PAH) induced by chronic exposure to cigarette smoke. 48 healthy male SD rats were randomly divided into four groups (12/group): control group (group A);...
Bruce J Shenker et al.
Infection and immunity, 83(4), 1487-1496 (2015-02-04)
The cytolethal distending toxin (Cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that the active toxin subunit functions as a phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase...
Malte Butzlaff et al.
Human molecular genetics, 24(13), 3623-3637 (2015-03-22)
The gene mapt codes for the microtubule-associated protein Tau. The R406W amino acid substitution in Tau is associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) characterized by Tau-positive filamentous inclusions. These filamentous Tau inclusions are present in...
Cecile Le Saout et al.
PLoS pathogens, 10(3), e1003976-e1003976 (2014-03-08)
HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic...
Raquel Ordoñez et al.
Journal of pineal research, 59(2), 178-189 (2015-05-16)
Autophagy is a process that maintains homeostasis during stress, although it also contributes to cell death under specific contexts. Ceramides have emerged as important effectors in the regulation of autophagy, mediating the crosstalk with apoptosis. Melatonin induces apoptosis of cancer...
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Ling Lian et al.
Poultry science, 94(11), 2616-2621 (2015-10-27)
Marek's disease (MD), caused by Marek's disease virus (MDV), is a lymphoproliferative neoplastic disease of chickens and is characterized by MD lymphoma in multiple visceral organs of chicken. It causes great damage to poultry health. Recently, miRNA has been reported...
Emiko Kasahara et al.
Neuroimmunomodulation, 22(5), 279-292 (2015-06-16)
Although psychological and/or physiological stress has been well documented to influence immune responses, the precise mechanism for immunomodulation remains to be elucidated. The present work describes the role of the hypothalamic-pituitary-adrenal (HPA) axis in the mechanism of stress-mediated enhanced-resistance to...
Jamie A Greig et al.
PLoS pathogens, 11(1), e1004630-e1004630 (2015-01-27)
The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...
Katheryne Benini Martins et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 46(2), 535-543 (2015-08-15)
The objective of this study was to characterize the clonal profile, virulence factors and antimicrobial resistance, particularly oxacillin resistance, of Staphylococcus aureus isolated from sheep milk. Milk samples were collected from all teats for the California Mastitis Test (CMT), somatic...
Raju Khatri et al.
Molecular cancer therapeutics, 14(7), 1728-1737 (2015-05-16)
Aromatase inhibitors are effective drugs that reduce or eliminate hormone-sensitive breast cancer. However, despite their efficacy, resistance to these drugs can occur in some patients. The INrf2 (Keap1):Nrf2 complex serves as a sensor of drug/radiation-induced oxidative/electrophilic stress. INrf2 constitutively suppresses...
Hiroshi Yoneyama et al.
Anti-cancer drugs, 26(1), 90-100 (2014-09-05)
The efficacy of gemcitabine (GEM), a standard treatment agent for pancreatic cancer, is insufficient because of primary or acquired resistance to this drug. Patients with tumors intrinsically sensitive to GEM gradually acquire resistance and require a shift to second agents...
Alexander M Holtz et al.
The Journal of cell biology, 209(5), 739-757 (2015-06-10)
Vertebrate Hedgehog (HH) signaling is controlled by several ligand-binding antagonists including Patched-1 (PTCH1), PTCH2, and HH-interacting protein 1 (HHIP1), whose collective action is essential for proper HH pathway activity. However, the molecular mechanisms used by these inhibitors remain poorly understood....
Senem Aykul et al.
PloS one, 10(1), e0114954-e0114954 (2015-01-21)
The Transforming Growth Factor-ß (TGFß) family ligand Nodal is an essential embryonic morphogen that is associated with progression of breast and other cancers. It has therefore been suggested that Nodal inhibitors could be used to treat breast cancers where Nodal...
Bin Zheng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 254-264 (2015-06-28)
Proliposomes containing a bile salt were developed to improve the oral bioavailability of Ginkgo biloba extract (GbE). GbE loaded proliposomes (P-GbE) were successfully prepared by spray drying method. The formulation was optimized using the response surface methodology. FE-SEM, DSC, and...
Jianxiong Jiang et al.
Neurobiology of disease, 76, 126-136 (2015-01-21)
As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) mediates brain inflammation and injury in many chronic central nervous system (CNS) conditions including seizures and epilepsy, largely through its receptor subtype EP2. However, EP2 receptor activation might also...
Beatrice Terni et al.
Journal of Alzheimer's disease : JAD, 46(2), 461-469 (2015-09-25)
Previous studies have shown that metalloproteinases (MMPs) participate in the clearance of amyloid-β (Aβ) in Alzheimer's disease (AD); MMP2 and MMP3 cleave soluble Aβ, and both MMP9 and MT1-MMP are able to degrade soluble and fibrillar forms of Aβ. The...
Ananthamohan Kalyani et al.
Journal of molecular biology, 427(16), 2629-2646 (2015-07-15)
Renalase, a recently identified oxidoreductase, is emerging as a novel regulator of cardiovascular and metabolic disease states. The mechanism of regulation of renalase gene, especially at the post-transcriptional level, is completely unknown. We set out to investigate the possible role...
Yasong Wu et al.
Nature cell biology, 17(6), 715-725 (2015-05-20)
We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc), henceforth 4F. This process occurs independently of p53 activation, and is mediated by the...
Takuya Yashiro et al.
PloS one, 10(9), e0137699-e0137699 (2015-09-12)
The transcription factor PU.1 is predominantly expressed in dendritic cells (DCs) and is essential for DC differentiation. Although there are several reports that PU.1 positively regulates the expression of DC-specific genes, whether PU.1 also has a suppressive effect on DCs...
Yael Riahi et al.
Journal of cellular and molecular medicine, 19(8), 1887-1899 (2015-03-11)
Vascular endothelial cell (VEC) senescence is considered an early event in the development of atherosclerotic lesions. Stressful stimuli, in particular oxidative stress, have been linked to premature senescence in the vasculature. Foam cells are a major source of reactive oxygen...
Keira J Lucas et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(5), 1440-1445 (2015-01-22)
Female mosquitoes require a blood meal for reproduction, and this blood meal provides the underlying mechanism for the spread of many important vector-borne diseases in humans. A deeper understanding of the molecular mechanisms linked to mosquito blood meal processes and...
Slawomir Antoszczyk et al.
Neuro-oncology, 16(8), 1057-1066 (2014-01-29)
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive and often lethal sarcoma that frequently develops in patients with neurofibromatosis type 1 (NF1). We developed new preclinical MPNST models and tested the efficacy of oncolytic herpes simplex viruses (oHSVs), a...
Elizabeth S Chan et al.
Scientific reports, 5, 13842-13842 (2015-09-09)
It is unclear how human apolipoprotein E4 (ApoE4) increases the risk for Alzheimer's disease (AD). Although Aβ levels can lead to insulin signaling impairment, these experiments were done in the absence of human ApoE. To examine ApoE role, we crossed...
Dieter A Kubli et al.
PloS one, 10(6), e0130707-e0130707 (2015-06-26)
Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells. However, how the PINK1/Parkin pathway regulates mitochondrial quality control and whether...
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