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Deborah Rotoli et al.
Oncology letters, 12(2), 1315-1322 (2016-07-23)
The immunophilin FK506-binding protein 5 (FKBP51) is a scaffold protein that serves a pivotal role in the regulation of multiple signaling pathways, integrating external and internal stimuli into distinct signal outputs. In a previous study, we identified several genes that
Hong-Bin Wang et al.
ACS chemical neuroscience, 11(18), 2869-2880 (2020-08-14)
Aneurysmal subarachnoid hemorrhage (SAH) causes permanent neurological sequelae, but the underlying mechanism needs to be further clarified. Here, we show that inhibition of metabotropic glutamate receptor 1 (mGluR1) with negative allosteric modulator JNJ16259685 improves long-term neurobehavioral outcomes in an endovascular
Anna Tankiewicz-Kwedlo et al.
British journal of pharmacology, 175(5), 743-762 (2017-11-22)
Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase involved in the activation of signalling pathways responsible for cell maturation and viability. Btk has previously been reported to be overexpressed in colon cancers. This kind of cancer is often accompanied
Deborah Rotoli et al.
Oncology letters, 14(3), 2621-2628 (2017-09-21)
IQGAP1 is a scaffolding protein that serves a key role in cell dynamics by integrating internal and external stimuli to distinct signal outputs. Previous studies have identified several genes that are significantly up- or downregulated in the peripheral white cells
Tigran P Norekian et al.
The Biological bulletin, 237(1), 36-47 (2019-08-24)
The pteropod mollusc Clione limacina is a feeding specialist, preying on shelled pteropods of the genus Limacina. Specialized prey-capture structures, called buccal cones, are hydraulically everted from within the mouth to capture the prey. Once captured, the prey is manipulated
Maria Buffini et al.
Journal of anatomy, 217(3), 187-195 (2010-07-16)
The external urethral sphincter (EUS) and external anal sphincter (EAS) are the principal voluntary striated muscles that sustain continence of urine and faeces. In light of their common embryological origin, shared tonic sphincteric action and synchronized electrical activity in vivo
Tamara E Galarza et al.
Biochemical pharmacology, 180, 114177-114177 (2020-07-30)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. In this
Deborah Rotoli et al.
International journal of molecular sciences, 18(1) (2017-01-19)
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of
Haixin Chang et al.
Biology of reproduction, 85(2), 296-305 (2011-03-11)
Hyperactivation, a swimming pattern of mammalian sperm in the oviduct, is essential for fertilization. It is characterized by asymmetrical flagellar beating and an increase of cytoplasmic Ca(2+). We observed that some mouse sperm swimming in the oviduct produce high-amplitude pro-hook
Golgi-mediated glycosylation determines residency of the T2 RNase Rny1p in Saccharomyces cerevisiae.
Natalia Shcherbik
Traffic (Copenhagen, Denmark), 14(12), 1209-1227 (2013-10-10)
The role of glycosylation in the function of the T2 family of RNases is not well understood. In this work, we examined how glycosylation affects the progression of the T2 RNase Rny1p through the secretory pathway in Saccharomyces cerevisiae. We
Marian E Durkin et al.
FEBS letters, 579(5), 1191-1196 (2005-02-16)
DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were
Placental transfer of IgG subclasses in a Japanese population.
Hashira S, et al.
Pediatrics International, 42(4) (2000)
Yusuke Sakai et al.
Biomaterials, 65, 66-75 (2015-07-06)
Subcutaneous liver tissue engineering is an attractive and minimally invasive approach used to curative treat hepatic failure and inherited liver diseases. However, graft failure occurs frequently due to insufficient infiltration of blood vessels (neoangiogenesis), while the maintenance of hepatocyte phenotype
Yoshihisa Hirakawa et al.
BMC plant biology, 15, 276-276 (2015-11-12)
Division of double-membraned plastids (primary plastids) is performed by constriction of a ring-like division complex consisting of multiple plastid division proteins. Consistent with the endosymbiotic origin of primary plastids, some of the plastid division proteins are descended from cyanobacterial cell
Joel Fürstenberg-Hägg et al.
PloS one, 9(10), e108745-e108745 (2014-10-10)
The evolution of sequestration (uptake and accumulation) relative to de novo biosynthesis of chemical defense compounds is poorly understood, as is the interplay between these two strategies. The Burnet moth Zygaena filipendulae (Lepidoptera) and its food-plant Lotus corniculatus (Fabaceae) poses
Fei Gao et al.
Reproduction (Cambridge, England), 148(4), 377-387 (2014-07-18)
The Wilms' tumour 1 (WT1) gene originally identified as a tumour suppressor associated with WTs encodes a zinc finger-containing transcription factor that is expressed in multiple tissues and is an important regulator of cellular and organ growth, proliferation, development, migration
Isha Sharma et al.
Biomedicines, 8(7) (2020-07-28)
Obesity is associated with perturbations in cellular energy homeostasis and consequential renal injury leading to chronic renal disease (CKD). Myo-inositol oxygenase (MIOX), a tubular enzyme, alters redox balance and subsequent tubular injury in the settings of obesity. Mechanism(s) for such
Yongning Zhang et al.
Autophagy, 7(6), 613-628 (2011-04-05)
A growing number of studies have demonstrated that autophagy has a diverse role in the infection process of different pathogens. However, to date, it is unknown whether autophagy is activated in encephalomyocarditis virus (EMCV)-infected host cells, and if so, what
Ping-Ping Yao et al.
PloS one, 7(12), e51996-e51996 (2013-01-04)
A reliable disease model mimicking Enterovirus 71 (EV71) infection in humans is essential for understanding pathogenesis and for developing a safe and effective vaccine. Commonly used rodent models including mouse or rat models are not suitable for vaccine evaluation because
Anup K Srivastava et al.
Biomaterials science, 8(5), 1345-1363 (2020-01-09)
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and localized deposition of cytoplasmic fibrillary inclusions as Lewy bodies in the brain. The aberrant phosphorylation of α-synuclein at serine 129 is the key process
Opposite regulation of tenascin-C and tenascin-X in MeLiM swine heritable cutaneous malignant melanoma
Geffrotin C, et al.
Biochim. Biophys. Acta Gen. Subj., 1524(2-3), 196-202 (2000)
Liam A Ridge et al.
PLoS genetics, 13(10), e1007068-e1007068 (2017-10-31)
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovascular disease will be
Karolina Förnvik et al.
PloS one, 12(9), e0183086-e0183086 (2017-09-08)
Glioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body's immune response. The complement system acts as a functional bridge between the innate
Ga-Bin Park et al.
Oncology letters, 16(4), 4526-4536 (2018-09-15)
Treatment with celecoxib and bortezomib as single chemotherapeutic agents reduces the viability and proliferation of colorectal cancer cells. The use of these agents in combination with other chemotherapeutic agents is usually associated with adverse effects. In the present study, a
Nicholas Theodosakis et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 64(7), 403-411 (2016-06-09)
We developed a method, termed Cell and Tissue Display (CTD), for embedding 16 or more different tissue samples in multi-compartment agarose blocks. The CTD-generated blocks allow uniform multiplexing of cell lines and small tissue fragments within a single histologic block.
Masaki Kobayashi et al.
Disease models & mechanisms, 10(3), 215-224 (2017-03-03)
Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus. Here, we provide structural and functional evidence for aberrant pre-mRNA splicing in a chronic type 1
Tiina Tyni et al.
Pediatric research, 56(5), 744-750 (2004-09-07)
The retinal pigment epithelium (RPE) and the choriocapillaris are affected early in the retinopathy associated with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. RPE in culture possesses the machinery needed for mitochondrial fatty acid beta-oxidation in vitro. To further elucidate pathogenesis of
Filomena Napolitano et al.
International journal of molecular sciences, 22(7) (2021-04-04)
Pompe disease is an autosomal recessive disorder caused by a deficiency in the enzyme acid alpha-glucosidase. The late-onset form of Pompe disease (LOPD) is characterized by a slowly progressing proximal muscle weakness, often involving respiratory muscles. In LOPD, the levels
Paritosh Mondal et al.
Aquatic toxicology (Amsterdam, Netherlands), 213, 105219-105219 (2019-06-14)
Nrf2 is a crucial transcription factor that regulates the expression of cytoprotective enzymes and controls cellular redox homeostasis. Both arsenic and fluoride are potent toxicants that are known to induce Nrf2. They are reported to coexist in many areas of
Swamy K Tripurani et al.
Endocrinology, 152(3), 1013-1023 (2011-01-05)
Newborn ovary homeobox (NOBOX) is an oocyte-specific transcription factor essential for folliculogenesis and expression of many germ cell-specific genes in mice. Here we report the characterization of the bovine NOBOX gene and its role in early embryogenesis. The cloned cDNA
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