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Hiroyuki Okano et al.
Nature microbiology, 5(1), 206-215 (2019-12-11)
Many microorganisms exhibit nutrient preferences, exemplified by the 'hierarchical' consumption of certain carbon substrates. Here, we systematically investigate under which physiological conditions hierarchical substrate utilization occurs and its mechanisms of implementation. We show utilization hierarchy of Escherichia coli to be...
Florence Hariton et al.
Oxidative medicine and cellular longevity, 2018, 5642148-5642148 (2019-01-01)
Increased cell senescence contributes to the pathogenesis of aging and aging-related disease. Senescence of human fibroblasts in vitro may be delayed by culture in low glucose concentration. There is also accumulating evidence of senescence delay by exposure to dietary bioactive...
Helen H Tai et al.
Plant physiology and biochemistry : PPB, 146, 163-176 (2019-11-23)
Tubers are vegetative reproduction organs formed from underground extensions of the plant stem. Potato tubers are harvested and stored for months. Storage under cold temperatures of 2-4 °C is advantageous for supressing sprouting and diseases. However, development of reducing sugars can...
Markus Basan et al.
Nature, 528(7580), 99-104 (2015-12-04)
Overflow metabolism refers to the seemingly wasteful strategy in which cells use fermentation instead of the more efficient respiration to generate energy, despite the availability of oxygen. Known as the Warburg effect in the context of cancer growth, this phenomenon...
Seung-Yon Lee et al.
Nature communications, 9(1), 4831-4831 (2018-11-18)
Much of the mammalian skeleton originates from a cartilage template eventually replaced by bone via endochondral ossification. Despite much knowledge about growth factors and nuclear proteins in skeletal development, little is understood about the role of metabolic regulation. Here we...
Kunst, A., et al.
Methods of Enzymatic Analysis, 163-172 (1984)
Gérard Manière et al.
Cell reports, 17(1), 137-148 (2016-09-30)
Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs) sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like...
Yulin Liu et al.
Oncotarget, 8(15), 25372-25383 (2017-04-28)
Interleukin-22 has been explored extensively in human cancer, but its functions and underlying mechanisms are incompletely understood. Here, we show that aberrant interleukin-22 expression facilitates aerobic glycolysis in colon cancer cells. Elevated interleukin-22 mRNA expression was observed and positively correlated...
Richard W Hagan et al.
Scientific reports, 8(1), 6804-6804 (2018-05-03)
Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of mosquito biology. Here, we examined underlying changes in the biology of mosquitoes associated with dehydration. Specifically, we...
Wei Chen et al.
Theranostics, 10(13), 5879-5894 (2020-06-03)
Rationale: Interleukin 22 (IL-22) is an epithelial survival cytokine that is at present being explored as therapeutic agents for acute and chronic liver injury. However, its molecular basis of protective activities remains poorly understood. Methods: Here we demonstrate that IL-22...
Katie E Marshall et al.
The Journal of experimental biology, 221(Pt 15) (2018-06-14)
Internal ice formation leads to wholesale changes in ionic, osmotic and pH homeostasis, energy metabolism, and mechanical damage, across a small range of temperatures, and is thus an abiotic stressor that acts at a distinct, physiologically relevant, threshold. Insects that...
Ranjani Dhakshinamoorthy et al.
Frontiers in cell and developmental biology, 9, 599525-599525 (2021-03-23)
The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that unite and...
Yu Shi et al.
eLife, 6 (2017-12-06)
Obesity poses a significant risk of developing type II diabetes and other diseases. Hedgehog (Hh) signaling has been shown to inhibit adipose tissue development, but its effect on diet-induced obesity during postnatal life is not known. Here by inducing expression...
Yangkyun Oh et al.
Nature, 574(7779), 559-564 (2019-10-28)
Although glucose-sensing neurons were identified more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here we identify a pair of glucose-sensing neurons with bifurcated axons in the brain of Drosophila. One axon branch projects...
Clément Vulin et al.
Biophysical journal, 106(10), 2214-2221 (2014-05-24)
Microorganisms often form complex multicellular assemblies such as biofilms and colonies. Understanding the interplay between assembly expansion, metabolic yield, and nutrient diffusion within a freely growing colony remains a challenge. Most available data on microorganisms are from planktonic cultures, due...
T E Weber et al.
Journal of animal science, 92(9), 4172-4179 (2014-07-16)
Humic acid (MFG) and fat-protected butyric acid (BA) has been shown to modulate energy metabolism and inflammation. Therefore, the objectives of this study were to determine the effects of MFG and BA, alone and in combination, on growth performance and...
Wresti L Anggayasti et al.
Engineering in life sciences, 20(7), 232-238 (2020-07-11)
Cancer research is increasingly focused on discovering strategies to induce cancer cell apoptosis without affecting surrounding normal cells. One potential biocompatible method is mechanical vibration, which has been developed as part of the emerging field of mechanomedicine. Previous studies of...
Roja Babazadeh et al.
Scientific reports, 7(1), 990-990 (2017-04-22)
Adaptation to altered osmotic conditions is a fundamental property of living cells and has been studied in detail in the yeast Saccharomyces cerevisiae. Yeast cells accumulate glycerol as compatible solute, controlled at different levels by the High Osmolarity Glycerol (HOG) response...
Ranjana Maurya et al.
Open biology, 7(7) (2017-07-14)
Starved Dictyostelium cells aggregate into groups of nearly 105 cells. AMPK is a highly conserved serine/threonine protein kinase consisting of a catalytic and two regulatory subunits. As multi-cellular development in Dictyostelium is initiated upon starvation, we explored the role of...
Saheed Imam et al.
BMC systems biology, 5, 116-116 (2011-07-23)
Rhodobacter sphaeroides is one of the best studied purple non-sulfur photosynthetic bacteria and serves as an excellent model for the study of photosynthesis and the metabolic capabilities of this and related facultative organisms. The ability of R. sphaeroides to produce...
Jinan Guo et al.
Frontiers in oncology, 9, 1242-1242 (2019-12-19)
MicroRNAs (miRNAs) are endogenous non-coding RNAs that negatively regulate the expression of downstream targeted mRNAs. Increasing evidence has suggested that miRNAs act as tumor suppressors or oncogenes to interfere the progression of cancers. Here, we showed that miR-204-3p was decreased...
Nasna Nassir et al.
PLoS genetics, 15(6), e1008188-e1008188 (2019-06-27)
Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum, we show that the protein encoded by tert has...
Monica Dus et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11644-11649 (2011-06-29)
Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of food deprivation and metabolic needs in the selection of appropriate food is poorly understood. Here, we show that the fruit fly, Drosophila melanogaster...
Jessica Fuhrmeister et al.
EMBO molecular medicine, 8(6), 654-669 (2016-05-04)
Recent studies have demonstrated that repeated short-term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we show...
Courtney M Anderson et al.
Skeletal muscle, 5, 7-7 (2015-03-20)
Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, contractile speed, and force...
Umi Enomoto et al.
Engineering in life sciences, 20(9-10), 402-411 (2020-09-19)
Regulating the collective migration of cells is an important issue in bioengineering. Enhancing or suppressing cell migration and controlling the migration direction is useful for various physiological phenomena such as wound healing. Several methods of migration regulation based on different...
Miao Liu et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e920810-e920810 (2020-05-30)
BACKGROUND Nicotinamide can affect differentiation and proliferation of leukemia cells. This research aimed to explore the regulatory effect of nicotinamide on glycolysis metabolism of leukemia cells and to clarify the associated mechanisms. MATERIAL AND METHODS HL-60 cells were treated with...
Emel Esen et al.
Cell metabolism, 17(5), 745-755 (2013-04-30)
WNT signaling controls many biological processes including cell differentiation in metazoans. However, how WNT reprograms cell identity is not well understood. We have investigated the potential role of cellular metabolism in WNT-induced osteoblast differentiation. WNT3A induces aerobic glycolysis known as...
Dona R Wisidagama et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 248(9), 762-770 (2019-06-09)
The ADCK proteins are predicted mitochondrial kinases. Most studies of these proteins have focused on the Abc1/Coq8 subfamily, which contributes to Coenzyme Q biosynthesis. In contrast, little is known about ADCK1 despite its evolutionary conservation in yeast, Drosophila, Caenorhabditis elegans...
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