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John K Williams et al.
American journal of public health, 103(8), 1476-1484 (2013-06-15)
HIV transmission risk is high among men who have sex with men and women (MSMW), and it is further heightened by a history of childhood sexual abuse (CSA) and current traumatic stress or depression. Yet, traumatic stress is rarely addressed...
Mark R Dadds et al.
Child development, 86(5), 1311-1320 (2015-07-15)
Behavioral/emotional difficulties in children are the first sign of mental health problems. These problems are however, heterogeneous. A domain that may identify homogenous subgroups is hypothalamic-pituitary-adrenal function. This study tested whether epigenetic regulation of glucocorticoid receptor gene could explain the...
Leslie B Hart et al.
PloS one, 10(5), e0127432-e0127432 (2015-05-21)
Inshore common bottlenose dolphins (Tursiops truncatus) are exposed to a broad spectrum of natural and anthropogenic stressors. In response to these stressors, the mammalian adrenal gland releases hormones such as cortisol and aldosterone to maintain physiological and biochemical homeostasis. Consequently...
Jean-Benoît Corcuff et al.
European journal of endocrinology, 172(4), 473-481 (2015-01-28)
Severe Cushing's syndrome elicited by ectopic ACTH syndrome (EAS) or adrenal carcinoma (ACC) can threaten life in the short term. The effectiveness of oral administration of the inhibitors of steroidogenesis ketoconazole and metyrapone in this situation is poorly described. To...
Minna U Kaikkonen et al.
Nucleic acids research, 42(20), 12570-12584 (2014-10-30)
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells...
Alexandra Ursache et al.
Physiology & behavior, 138, 266-272 (2014-12-03)
Physiological responses to threat occur through both the autonomic nervous system (ANS) and the hypothalamic pituitary adrenal (HPA) axis. Activity in these systems can be measured through salivary alpha-amylase (sAA) and salivary cortisol, respectively. Theoretical work and empirical studies have...
Daniel Berry et al.
Developmental psychology, 50(2), 514-525 (2013-06-19)
A considerable body of literature suggests that children's child-care experiences may impact adrenocortical functioning in early childhood. Yet emerging findings also suggest that the magnitude and sometimes the direction of child-care effects on development may be markedly different for children...
Q Li et al.
Oncogene, 33(20), 2589-2600 (2013-06-12)
The major goal of breast cancer prevention is to reduce the incidence of ductal carcinoma in situ (DCIS), an early stage of breast cancer. However, the biology behind DCIS formation is not well understood. It is suspected that cancer stem...
Christine M Helfer et al.
Viruses, 6(8), 3228-3249 (2014-08-21)
The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral...
Ashley J Parks et al.
Molecular pharmacology, 86(5), 593-608 (2014-08-28)
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual...
Maike Ter Wolbeek et al.
Brain, behavior, and immunity, 45, 128-138 (2014-12-03)
Neonatal glucocorticoid (GC) treatment is used to prevent bronchopulmonary dysplasia (BPD) in prematurely born babies. In the 1990s, treatment regimens with relatively high doses of dexamethasone (DEX) were common. As an alternative, hydrocortisone (HC) was used. Earlier, we compared long-term...
Filip Růžička et al.
Psychoneuroendocrinology, 52, 302-310 (2015-01-03)
Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation to the position of active stimulating contact within the...
Mario Cioce et al.
Oncotarget, 5(12), 4129-4143 (2014-07-02)
Metabolic remodeling is a hallmark of cancer progression and may affect tumor chemoresistance. Here we investigated by 1H-NMR/PCA analysis the metabolic profile of chemoresistant breast cancer cell subpopulations (ALDHbright cells) and their response to metformin, a promising anticancer metabolic modulator....
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from...
Kimberly Albert et al.
Psychoneuroendocrinology, 59, 14-24 (2015-07-01)
Although ovarian hormones are thought to have a potential role in the well-known sex difference in mood and anxiety disorders, the mechanisms through which ovarian hormone changes contribute to stress regulation are not well understood. One mechanism by which ovarian...
Nicola Manzella et al.
Scientific reports, 5, 13752-13752 (2015-09-05)
The DNA base excision repair pathway is the main system involved in the removal of oxidative damage to DNA such as 8-Oxoguanine (8-oxoG) primarily via the 8-Oxoguanine DNA glycosylase (OGG1). Our goal was to investigate whether the repair of 8-oxoG...
Can Lu et al.
Journal of cellular biochemistry, 115(8), 1458-1466 (2014-03-13)
Parthenolide is the main bioactive component in feverfew, a common used herbal medicine, and has been extensively studied in relation to its anti-cancer properties. However there have been very few in-depth studies of the activities of this compound at the...
Alice Fraveto et al.
PloS one, 10(11), e0142124-e0142124 (2015-11-17)
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures of mucin- and mixed-IHCCA were prepared from surgical specimens (N. 18 IHCCA patients) and evaluated for cell proliferation (MTS assay) and apoptosis (Caspase...
Zhi-qiang Pan et al.
Molecular and cellular endocrinology, 394(1-2), 119-128 (2014-07-20)
Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid...
Gustav Schelling et al.
Annals of the New York Academy of Sciences, 1071, 46-53 (2006-08-08)
Like other humans exposed to extreme trauma, patients who have been treated in an intensive care unit (ICU) often report traumatic memories. Extremely traumatic memories from the ICU in some of these patients are associated with the development of posttraumatic...
Jackie Swartz et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 26(2), 153-160 (2015-01-27)
Infants from anthroposophic families have low cortisol levels and low risk of IgE-sensitization during first 2 years of life. Our aim was to study the impact of an anthroposophic lifestyle and cortisol levels at 6 months on allergy sensitization up to age...
Bruna Maria Manzini et al.
Cytotherapy, 17(8), 1052-1065 (2015-07-04)
End-stage liver diseases frequently require liver transplantation. Cell therapy could be an alternative. This study aimed to analyze whether undifferentiated mesenchymal stromal cells (U-MSCs) or MSC-derived hepatocyte-like cells (DHLCs) from adipose tissue (AT), umbilical cord blood (UCB) and bone marrow...
Negar Tabatabaei et al.
Journal of bone and mineral metabolism, 33(3), 253-260 (2014-05-27)
The effect of the inhaled anaesthetic isoflurane was investigated on bone biomarkers, both during maturation and on minerals and glucose postpartum. Female guinea pigs (n = 10) were anaesthetized during maturation (5 and 9 weeks) and postpartum (26 weeks of age) with isoflurane during...
Rachel Yehuda et al.
Psychoneuroendocrinology, 51, 589-597 (2014-09-13)
Prolonged exposure (PE) therapy for post-traumatic stress disorder (PTSD) in military veterans has established efficacy, but is ineffective for a substantial number of patients. PE is also associated with high dropout rates. We hypothesized that hydrocortisone augmentation would enhance symptom...
Daniela Schwarzenbacher et al.
Oncotarget, 6(13), 11191-11202 (2015-04-11)
Spinophilin, a putative tumor suppressor gene, has been shown to be involved in the pathogenesis of certain types of cancer, but its role has never been systematically explored in breast cancer. In this study, we determined for the first time...
Buqing Yi et al.
Scientific reports, 5, 13367-13367 (2015-08-27)
Environmental factors have long been known to influence immune responses. In particular, clinical studies about the association between migration and increased risk of atopy/asthma have provided important information on the role of migration associated large sets of environmental exposures in...
Darby E Saxbe et al.
Psychoneuroendocrinology, 62, 121-128 (2015-08-25)
Covariation in diurnal cortisol has been observed in several studies of cohabiting couples. In two such studies (Liu et al., 2013; Saxbe and Repetti, 2010), relationship distress was associated with stronger within-couple correlations, suggesting that couples' physiological linkage with each...
Jen-Chieh Lin et al.
Endocrinology, 156(8), 2854-2862 (2015-05-15)
HSD3B catalyzes the synthesis of δ4 steroids such as progesterone in the adrenals and gonads. Individuals lacking HSD3B2 activity experience congenital adrenal hyperplasia with imbalanced steroid synthesis. To develop a zebrafish model of HSD3B deficiency, we characterized 2 zebrafish hsd3b...
Michael G C Kahn et al.
Bioorganic & medicinal chemistry letters, 16(13), 3454-3458 (2006-04-29)
Fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids have high affinity for the glucocorticoid receptor (GR) and are highly active glucocorticoids. They are thus considered to be excellent candidates for PET imaging of GR containing tissues when labeled with fluorine-18 (t(1/2)=110 min). Previously reported...
Anna Wiktorowska-Owczarek et al.
Cellular & molecular biology letters, 20(2), 213-221 (2015-07-24)
Prostaglandin E2 (PGE2) is generated in various cells, including endothelial cells, and is responsible for various functions, such as vascular relaxation and angiogenesis. Effects of PGE2 are mediated via receptors EP1-EP4, among which EP2 and EP4 are coupled to Gs...
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