HPA029100

Filtros aplicados

Palabra clave:'HPA029100'

Mostrando 1-10 of 10 resultados para "HPA029100" en el plazo de Papeles

Unique properties of lamp2a compared to other lamp2 isoforms.

Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)

Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy.

Maron BJ, et al.

JAMA : The Journal of the American Medical Association, 301(12), 1253-1259 (2009)

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.

Damaghi M, et al.

Nature Communications, 6:8752 (2015)

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation.

Sofia Avnet et al.

International journal of cancer, 140(6), 1331-1345 (2016-11-27)

The role of mesenchymal stem cells (MSC) in osteosarcoma (OS), the most common primary tumor of bone, has not been extensively elucidated. We have recently shown that OS is characterized by interstitial acidosis, a microenvironmental condition that is similar to

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma.

Gemma Di Pompo et al.

Oncotarget, 8(33), 54478-54496 (2017-09-15)

Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are limited since they are often ineffective. Local acidosis derived from glycolytic carcinoma and tumor-induced osteolysis is only

Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target.

Margherita Cortini et al.

Cancers, 13(2) (2021-01-21)

Acidity is a key player in cancer progression, modelling a microenvironment that prevents immune surveillance and enhances invasiveness, survival, and drug resistance. Here, we demonstrated in spheroids from osteosarcoma cell lines that the exposure to acidosis remarkably caused intracellular lipid

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma.

Di Pompo G, et al.

Oncotarget (2017)

The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes.

Gibellini L, et al.

AIDS, 26(16), 2017-2026 (2012)

Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells.

Jang Hee Han et al.

Cancer communications (London, England), 42(8), 716-749 (2022-07-16)

Autophagy is elevated in metastatic tumors and is often associated with active epithelial-to-mesenchymal transition (EMT). However, the extent to which EMT is dependent on autophagy is largely unknown. This study aimed to identify the mechanisms by which autophagy facilitates EMT.

SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma.

Tomofumi Yamamoto et al.

Blood advances, 6(8), 2480-2495 (2022-01-04)

Multiple myeloma (MM) is a hematopoietic malignancy whose prognosis has improved with the development of new agents such as lenalidomide over the last decade. However, long-term exposure to drugs induces the acquisition of resistance by MM cells and leads to treatment

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