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Kristin A Sauter et al.
Journal of leukocyte biology, 96(2), 265-274 (2014-03-22)
We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant phenotype, including
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.
Sauter KA, Pridans C, Sehgal A, et al.
Journal of Leukocyte Biology, 96(2), 265-274 (2014)
Jon Gil-Ranedo et al.
Cell reports, 27(10), 2921-2933 (2019-06-06)
Adult stem cells reactivate from quiescence to maintain tissue homeostasis and in response to injury. How the underlying regulatory signals are integrated is largely unknown. Drosophila neural stem cells (NSCs) also leave quiescence to generate adult neurons and glia, a
Thomas B Martins et al.
Clinical and diagnostic laboratory immunology, 11(2), 325-329 (2004-03-12)
While modern immunoassays provide sensitive and specific means for the quantitation of cytokines in biological fluids, heterophile antibodies are still a well-recognized cause of interference in the measurement of cytokines in these assays. We have developed a multiplexed fluorescent microsphere
Coline Gaillard et al.
Haematologica, 100(8), 1064-1075 (2015-06-20)
Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in the bone marrow. PML/RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein initiates disease are incompletely understood.
D Hildeman et al.
Journal of virology, 71(12), 9672-9678 (1997-11-26)
Lymphocytic choriomeningitis virus (LCMV) infection of normal mice results in a fatal immunopathologic meningitis mediated by CD8+ cytotoxic T lymphocytes (CTL). We have previously shown that female beta2-microglobulin-deficient (beta2m-/-) mice, which are also deficient in CD8+ T cells, are susceptible
Hsueh-Yuan Chang et al.
mAbs, 10(6), 843-853 (2018-06-27)
Here, we present the first case-study where microdialysis is used to investigate the pharmacokinetics of antibody in different regions of rat brain. Endogenous IgG was used to understand antibody disposition at steady-state and exogenously administered trastuzumab was used to understand
Neutrophils instruct homeostatic and pathological states in naive tissues
Casanova-Acebes M, et al.
The Journal of Experimental Medicine, 215(11), 2778-2795 (2018)
Raquel Romay-Tallon et al.
Biomarker research, 5, 27-27 (2017-10-12)
The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depression. Here we evaluated the possibility of performing a similar
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation
Gaillard C, et al.
Haematologica, 100(8), 1064-1075 (2015)
Catherine Rush et al.
BMC genomics, 10, 298-298 (2009-07-08)
An animal model commonly used to investigate pathways and potential therapeutic interventions relevant to abdominal aortic aneurysm (AAA) involves subcutaneous infusion of angiotensin II within the apolipoprotein E deficient mouse. The aim of this study was to investigate genes differentially
Tamara Hilmenyuk et al.
Oncoimmunology, 7(1), e1365997-e1365997 (2018-01-04)
A reduced immune surveillance due to immune deficiency or treatment with immunosuppressive drugs is associated with a higher risk to develop aggressive Non-Hodgkin's lymphoma (NHL). Nevertheless, NHL also develops in immunocompetent patients indicating an escape from the immune system. T
Valérie Soulard et al.
Malaria journal, 8, 128-128 (2009-06-11)
In murine models of malaria, an early proinflammatory response has been associated with the resolution of blood-stage infection. To dissect the protective immune mechanism that allow the control of parasitaemia, the early immune response of C57BL/6 mice induced during a
Anuj Sehgal et al.
Nature communications, 9(1), 1272-1272 (2018-03-30)
Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but evidence of expression of CSF1R within the crypt is equivocal.
Boyi Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(47), E7572-E7579 (2016-11-09)
Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing content of the
Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
Irani V, et al.
Molecular Immunology, 67 (2015)
Hugh I McFarland et al.
PloS one, 7(6), e39092-e39092 (2012-06-23)
Sublethal total body γ irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide evidence that a part of this immune suppression may be attributable to dysfunction of immune regulation. We investigated the
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Bieniasz-Krzywiec, et al.
Cell Metabolism, 30, 917-936 (2020)
Dàlia Raïch-Regué et al.
Oncoimmunology, 5(6), e1146841-e1146841 (2016-07-30)
Dendritic cells (DC) play a pivotal role in the induction and regulation of immune responses. In cancer, DC-based vaccines have proven to be safe and to elicit protective and therapeutic immunological responses. Recently, we showed that specific mTORC2 (mechanistic target
Aline Bolpetti et al.
BMC immunology, 11, 27-27 (2010-06-08)
Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression.
A Gugliucci et al.
Life sciences, 62(23), 2141-2150 (1998-06-17)
As the glycation/glycoxidation hypothesis for the genesis of diabetic complications is achieving widespread acceptance, much attention is being paid to the role of low molecular weight advanced glycation (AGE) adducts, as second generation glycating agents. We set out a study
Comparative study of two protocols for quantitative image-analysis of serotonin transporter clustering in lymphocytes, a putative biomarker of therapeutic efficacy in major depression
Romay-Tallon R, et al.
Biomarker research, 5(1), 27-27 (2017)
Jasmine C Wong et al.
eLife, 4 (2015-07-21)
Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted
M Lahn et al.
Journal of immunology (Baltimore, Md. : 1950), 160(11), 5221-5230 (1998-05-30)
Although recent findings indicate that gamma delta T cells influence both early innate and Ag-specific adaptive host responses, it has remained unclear what triggers gamma delta T cell reactivity. Investigating very early T cell activation in mouse and human models
Thomas J Ellison et al.
PloS one, 9(11), e111502-e111502 (2014-11-18)
The availability of reliable recombinant reporter virus systems has been a great boon to the study of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Unexpectedly, we found that expression of the ostensibly constitutive green fluorescent protein (GFP) marker was progressively lost during unselected
Maria Stella Sasso et al.
Science advances, 7(13) (2021-03-26)
In melanoma, the induction of lymphatic growth (lymphangiogenesis) has long been correlated with metastasis and poor prognosis, but we recently showed it can synergistically enhance cancer immunotherapy and boost T cell immunity. Here, we develop a translational approach for exploiting
Hiroki Kabata et al.
Mucosal immunology, 13(4), 626-636 (2020-02-19)
Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis. Accumulating evidence suggests that TSLP can directly stimulate a variety of immune cells, such as dendritic cells (DCs), basophils
David J Cantor et al.
Cell reports, 26(1), 108-118 (2019-01-04)
B cell development is a highly regulated process that requires stepwise rearrangement of immunoglobulin genes to generate a functional B cell receptor (BCR). The polycomb group protein BMI1 is required for B cell development, but its function in developing B
Aisha Rafique et al.
International journal of nanomedicine, 14, 2829-2846 (2019-05-23)
Vitamin D3 possesses anti-inflammatory and modulatory properties in addition to its role in calcium and phosphate homeostasis. Upon activation, macrophages (M) can initiate and sustain pro-inflammatory cytokine production in inflammatory disorders and play a pathogenic role in certain cancers. The
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