Showing 1-30 of 32 resultados for "L0159"
Joon-Yung Cha et al.
Nature communications, 8(1), 3-3 (2017-02-25)
Circadian clock systems help establish the correct daily phasing of the behavioral, developmental, and molecular events needed for the proper coordination of physiology and metabolism. The circadian oscillator comprises transcription-translation feedback loops but also requires post-translational processes that regulate clock...
Isabel Ml Saur et al.
eLife, 8 (2019-02-20)
Nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins in plants and animals mediate intracellular pathogen sensing. Plant NLRs typically detect strain-specific pathogen effectors and trigger immune responses often linked to localized host cell death. The barley Mla disease resistance locus has...
Lyne Jossé et al.
Methods in molecular biology (Clifton, N.J.), 824, 595-608 (2011-12-14)
All proteins fold into a defined three-dimensional shape that is compatible with the cellular role and/or biological activity of those proteins. Molecular chaperones are a family of proteins whose role is to assist the folding and targeting of proteins in...
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Dong Ren et al.
The Journal of experimental medicine, 216(2), 428-449 (2018-12-30)
In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to be implicated in dormancy of cancer cells. However, how these tumor cells are kept...
Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts
Jose A, et al.
Testing, 4(1), 94-94 (2013)
Saskia Bauer et al.
PLoS pathogens, 17(2), e1009223-e1009223 (2021-02-04)
Nucleotide-binding domain leucine-rich repeat-containing receptors (NLRs) in plants can detect avirulence (AVR) effectors of pathogenic microbes. The Mildew locus a (Mla) NLR gene has been shown to confer resistance against diverse fungal pathogens in cereal crops. In barley, Mla has...
Anabel José et al.
Oncotarget, 4(1), 94-105 (2013-01-19)
Gene-based anticancer therapies delivered by adenoviruses are limited by the poor viral distribution into the tumor. In the current work we have explored the feasibility of targeting pancreatic tumors through a loco-regional route. We have taken advantage of the ductal...
Marco Chiabudini et al.
Molecular and cellular biology, 32(23), 4769-4779 (2012-09-26)
When a polyadenylated nonstop transcript is fully translated, a complex consisting of the ribosome, the nonstop mRNA, and the C-terminally polylysine-tagged protein is generated. In Saccharomyces cerevisiae, a 3-step quality control system prevents formation of such dead-end complexes. Nonstop mRNA...
Ayguen Sahin et al.
PloS one, 13(7), e0199414-e0199414 (2018-07-06)
Glioblastoma multiforme (GBM) is the most aggressive and deadly form of adult brain cancer. Despite of many attempts to identify potential therapies for this disease, including promising cancer immunotherapy approaches, it remains incurable. To address the need of improved persistence...
Taina Suntio et al.
Molecular plant pathology, 13(7), 775-784 (2012-02-22)
The effect of abiotic stress responses on Potato virus A (PVA; genus Potyvirus) infection was studied. Salt, osmotic and wounding stress all increased PVA gene expression in infected Nicotiana benthamiana leaves. According to the literature, an early response to these...
Anne-Sophie Gribling-Burrer et al.
Nucleic acids research, 47(13), 7018-7034 (2019-05-23)
The yeast ribosome-associated complex RAC and the Hsp70 homolog Ssb are anchored to the ribosome and together act as chaperones for the folding and co-translational assembly of nascent polypeptides. In addition, the RAC/Ssb system plays a crucial role in maintaining...
Paul Lin et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(1), 160-168 (2013-09-27)
It has been hypothesized that mesenchymal stem cells (MSCs) home to sites of injury. Nevertheless, efficient delivery of MSCs to target organs and description of their ultimate fate remain major challenges. We provide evidence that intra-arterially (IA) injected MSCs selectively...
Won-kyung Oh et al.
Biochemical and biophysical research communications, 347(4), 994-1000 (2006-07-21)
West Nile virus (WNV) is a member of the Flavivirus family and induces febrile illness, sporadic encephalitis, and paralysis. The capsid (Cp) of WNV is thought to play a role in inducing these symptoms through caspase-3- and caspase-9-dependent apoptosis. Using...
Antonio Filareto et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(30), 7741-7746 (2018-07-11)
Duchenne muscular dystrophy (DMD) is a rare, muscle degenerative disease resulting from the absence of the dystrophin protein. DMD is characterized by progressive loss of muscle fibers, muscle weakness, and eventually loss of ambulation and premature death. Currently, there is...
Katri Eskelin et al.
Journal of virology, 85(17), 9210-9221 (2011-06-24)
Viral protein genome-linked (VPg) plays a central role in several stages of potyvirus infection. This study sought to answer questions about the role of Potato virus A (PVA; genus Potyvirus) VPg in viral and host RNA expression. When expressed in...
A rapid and quantitative coat protein complex II vesicle formation assay using luciferase reporters
Fromme J Chris and Kim J
Analytical biochemistry, 421(2), 482-488 (2012)
Marco Quarta et al.
Nature communications, 8, 15613-15613 (2017-06-21)
Volumetric muscle loss (VML) is associated with loss of skeletal muscle function, and current treatments show limited efficacy. Here we show that bioconstructs suffused with genetically-labelled muscle stem cells (MuSCs) and other muscle resident cells (MRCs) are effective to treat...
Yan Wang et al.
Autophagy, 11(12), 2259-2274 (2015-11-15)
Microtubules, the major components of cytoskeleton, are involved in various fundamental biological processes in plants. Recent studies in mammalian cells have revealed the importance of microtubule cytoskeleton in autophagy. However, little is known about the roles of microtubules in plant...
Haoxi Chai et al.
The New phytologist, 226(3), 785-797 (2020-01-05)
In Arabidopsis, the plasma membrane transporter PUT3 is important to maintain the cellular homeostasis of polyamines and plays a role in stabilizing mRNAs of some heat-inducible genes. The plasma membrane Na+ /H+ transporter SOS1 and the protein kinase SOS2 are...
Ilona Turek et al.
The Journal of biological chemistry, 293(42), 16324-16336 (2018-09-07)
Ubiquitination is a prevalent post-translational modification involved in all aspects of cell physiology. It is mediated by an enzymatic cascade and the E2 ubiquitin-conjugating enzymes (UBCs) lie at its heart. Even though E3 ubiquitin ligases determine the specificity of the...
J Brian Robertson et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(46), 17988-17993 (2008-11-14)
The use of luciferase reporters has become a precise, noninvasive, high-throughput method for real-time monitoring of promoter activity in living cells, especially for rhythmic biological processes such as circadian rhythms. We developed a destabilized firefly luciferase as a reporter for...
Lyne Jossé et al.
Yeast (Chichester, England), 36(1), 43-51 (2018-12-15)
One of the central hypotheses in the theory of codon usage evolution is that in highly expressed genes, particular codon usage patterns arise because they facilitate efficient gene expression and are thus selected for in evolution. Here, we use plasmid...
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Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)...
Marco Chiabudini et al.
Molecular and cellular biology, 34(21), 4062-4076 (2014-08-27)
Ribosome stalling is an important incident enabling the cellular quality control machinery to detect aberrant mRNA. Saccharomyces cerevisiae Hbs1-Dom34 and Ski7 are homologs of the canonical release factor eRF3-eRF1, which recognize stalled ribosomes, promote ribosome release, and induce the decay...
Tapash Jay Sarkar et al.
Nature communications, 11(1), 1545-1545 (2020-03-27)
Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion...
Giulia Furlan et al.
The Plant cell, 29(4), 726-745 (2017-03-11)
Crosstalk between posttranslational modifications, such as ubiquitination and phosphorylation, play key roles in controlling the duration and intensity of signaling events to ensure cellular homeostasis. However, the molecular mechanisms underlying the regulation of negative feedback loops remain poorly understood. Here...
Dominique Chu et al.
The EMBO journal, 33(1), 21-34 (2013-12-21)
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias. Although recent studies have shown strong effects of codon...
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