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Johnson Chia-Shen Yang et al.
Journal of biomedical science, 21, 20-20 (2014-03-13)
Upon lipopolysaccharide (LPS) stimulation, activation of both the Toll-like receptor 4 (TLR4) and phosphoinositide 3-kinase (PI3K) pathways serves to balance proinflammatory and anti-inflammatory responses. Although the antagonist to TLR4 represents an emerging promising target for the treatment of sepsis; however
Behnam Abbasian et al.
mSphere, 4(5) (2019-09-06)
Urgency urinary incontinence (UUI) and overactive bladder (OAB) can both potentially be influenced by commensal and urinary tract infection-associated bacteria. The sensing of bladder filling involves interplay between various components of the nervous system, eventually resulting in contraction of the
Heidi Barth et al.
Journal of virology, 82(7), 3466-3479 (2008-01-25)
Class B scavenger receptors (SR-Bs) bind lipoproteins and play an important role in lipid metabolism. Most recently, SR-B type I (SR-BI) and its splicing variant SR-BII have been found to mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells.
Annette Ploppa et al.
Critical care (London, England), 14(6), R201-R201 (2010-11-10)
This study was carried out to determine whether interactions of cell activation, shear stress and platelets at sites of endothelial injury explain the paradoxical maldistribution of activated leukocytes during sepsis away from local sites of infection towards disseminated leukocyte accumulation
Hajar Benmhammed et al.
Behavioural brain research, 362, 46-55 (2019-01-11)
Preclinical studies of early-life adversity (ELA1) have highlighted the role of postnatal stress in the emergence and persistence of anxiety and depressive disorders. In this study, we compared anxious and depressive behaviors and oxidation levels in male and female Wistar
Zhankui Jia et al.
PPAR research, 2014, 541394-541394 (2014-02-14)
High mobility group box 1 (HMGB1) is a ubiquitous nuclear DNA-binding protein whose function is dependent on its cellular location. Extracellular HMGB1 is regarded as a delayed mediator of proinflammatory cytokines for initiating and amplifying inflammatory responses, whereas nuclear HMGB1
Jian Liang et al.
PloS one, 3(8), e2880-e2880 (2008-08-07)
Previously, we have identified a novel CCCH zinc finger protein family as negative regulators of macrophage activation. To gain an overall insight into the entire CCCH zinc finger gene family and to evaluate their potential role in macrophage activation, here
Ziwen Zhu et al.
Journal of leukocyte biology, 101(6), 1349-1359 (2017-03-10)
Bacterial pneumonia is a common and serious clinical entity. Alveolar epithelial cells and alveolar macrophages are the first line of defense in the innate immunity against bacterial pathogens. Epithelial cells are known to release chemokines/cytokines that recruit and activate phagocytic
Seungwha Paik et al.
Scientific reports, 9(1), 4342-4342 (2019-03-15)
The immunobiological functions of Rg6, a rare ginsenoside from ginseng, have been largely unreported. In this paper, we demonstrate that Rg6 has a significant immunosuppressive function on Toll-like receptor (TLR) 4-induced systemic inflammatory responses. Rg6 was found to negatively regulate
Jacque P K Ip et al.
Journal of neuroinflammation, 8, 124-124 (2011-09-29)
Lipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation. Therefore, here we investigated the regulation and possible function of Lcn2 in the
Ching-Hua Hsieh et al.
Journal of biomedical science, 20, 2-2 (2013-01-05)
Previously, we had identified a specific whole blood-derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was designed to profile the circulating miRNAs expression in mice exposed to lipoteichoic acid
Jean-Baptiste Cavin et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(2), G254-G264 (2019-11-12)
The small intestine regulates barrier function to absorb nutrients while avoiding the entry of potentially harmful substances or bacteria. Barrier function is dynamically regulated in part by the enteric nervous system (ENS). The role of the ENS in regulating barrier
Tsu-Tuan Wu et al.
Cytokine, 55(1), 40-47 (2011-04-09)
Surfactant proteins (SPs) and toll-like receptors (TLRs) contribute to regulation of sepsis-induced acute lung injury. Lipopolysaccharide (LPS) is one of the major causes of septic shock. This study was designed to evaluate the effects of LPS on the regulation of
Baichun Yang et al.
BMC pharmacology, 8, 7-7 (2008-05-14)
Glucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory response, and concerns over this exacerbation have limited the development and clinical use of GR antagonists in the treatment of diabetes and
Nathalia M Pinheiro et al.
International journal of molecular sciences, 22(14) (2021-07-25)
(1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation. This study investigated changes in the expression levels of nicotinic and muscarinic
Sverre Holm et al.
PloS one, 6(12), e28785-e28785 (2011-12-17)
Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking and associated inflammation. To further elucidate the role of FABP4 in atherogenesis in humans, we examined the regulation of FABP4 in carotid
Guohui Cai et al.
Frontiers in neuroscience, 8, 446-446 (2015-01-30)
Neonatal obesity predisposes individuals to obesity throughout life. In rats, neonatal overfeeding also leads to early accelerated weight gain that persists into adulthood. The phenotype is associated with dysfunction in a number of systems including paraventricular nucleus of the hypothalamus
Sandrine Benhamron et al.
Molecular and cellular biology, 35(1), 153-166 (2014-10-22)
Plasma cells (PCs) are responsible for the secretion of antibodies. The development of fully functional PCs relies on the activation of the inositol-requiring enzyme 1/X-box binding protein 1 (IRE1/XBP-1) arm of the unfolded protein response (UPR). XBP-1-deficient PCs secrete antibodies
Jae-Youn Choi et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 60(4), 301-315 (2012-01-21)
Although inducible nitric oxide synthase (iNOS) is known to play significant roles in the kidney, its renal localization has long been controversial. To resolve this issue, the authors identified iNOS-positive cell types in rat kidneys using double immunohistochemistry and confirmed
Rupali Sharma et al.
Journal of immunology (Baltimore, Md. : 1950), 202(7), 2131-2140 (2019-02-10)
Puberty is a critical period of development marked by sexual, immune, and neural maturation. Exposure to stress during this period can lead to enduring changes in brain functioning and in behavior; however, the underlying mechanisms and the programming effects of
Nathalia M Pinheiro et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(1), 320-332 (2016-10-13)
Nicotinic α-7 acetylcholine receptor (nAChRα7) is a critical regulator of cholinergic anti-inflammatory actions in several diseases, including acute respiratory distress syndrome (ARDS). Given the potential importance of α7nAChR as a therapeutic target, we evaluated whether PNU-282987, an α7nAChR agonist, is
Areum Park et al.
Nature communications, 10(1), 4670-4670 (2019-10-13)
The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways required for antiviral defense. Here, we report
Zachary I Grunewald et al.
Physiology & behavior, 199, 282-291 (2018-12-07)
Circulating levels of bacterial lipopolysaccharide (LPS) or endotoxin are chronically elevated in obesity (metabolic endotoxemia), resulting in low-grade inflammation. Metabolic endotoxemia has been identified as a triggering factor for obesity-associated metabolic complications such as insulin resistance. Furthermore, LPS has been
Johnson Chia-Shen Yang et al.
Journal of biomedical science, 22, 40-40 (2015-06-11)
The NF-κB signaling pathway plays a role in local and remote tissue damage following ischemia-reperfusion (I/R) injury to skeletal muscles. Evidence suggests that exosomes can act as intercellular communicators by transporting active proteins to remote cells and may play a
Julio Villatoro-Hernandez et al.
Microbial cell factories, 7, 22-22 (2008-07-30)
Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10 (IP-10) is a member of the C-X-C subfamily
Luba Sominsky et al.
Molecular and cellular endocrinology, 470, 295-303 (2017-12-01)
A poor nutritional environment during early development has long been known to increase disease susceptibility later in life. We have previously shown that rats that are overfed as neonates (i.e. suckled in small litters (4 pups) relative to control conditions
Georg Stoecklin et al.
Molecular and cellular biology, 23(10), 3506-3515 (2003-05-02)
Tumor necrosis factor alpha (TNF-alpha) expression is regulated by transcriptional as well as posttranscriptional mechanisms, the latter including the control of mRNA decay through an AU-rich element (ARE) in the 3' untranslated region (UTR). Using two mutant cell lines deficient
Rose B Joachim et al.
Molecular systems biology, 14(5), e7998-e7998 (2018-05-19)
Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections
Kyoung-Jin Jang et al.
Nature communications, 6, 6750-6750 (2015-04-11)
During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates and mitochondrial functions. CSR occurs specifically in
Yanhui Cai et al.
Journal of leukocyte biology, 97(6), 1147-1153 (2015-03-18)
We recently reported that increasing blood monocyte turnover that was associated with tissue macrophage death better predicts terminal disease progression in adult SIV-infected macaques than does declining CD4(+) T cell levels. To understand better mechanisms of pathogenesis, this study relates
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