Showing 1-21 of 21 resultados for "

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Preeyam S Patel et al.
Journal of immunology (Baltimore, Md. : 1950), 197(8), 3175-3187 (2016-09-02)
There is a higher incidence of allergic conditions among children living in industrialized countries than those in developing regions. One explanation for this is reduced neonatal exposure to microbes and the consequent lack of immune stimulation. Sensitivity to cockroach allergen...
Ming Gao et al.
Transfusion, 58(10), 2388-2394 (2018-09-12)
Although platelet microparticles (PMPs) were the most abundant micoparticles (MPs) in platelet (PLT) products, other MPs and their parental cells can also be brought into the plasma during PLT apheresis. However, the effects of PLT apheresis, storage time, and leukofiltration...
Mona Seifert et al.
Nucleic acids research, 48(10), 5591-5602 (2020-04-15)
RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp elongation traces...
Agustín Mangiarotti et al.
Langmuir : the ACS journal of surfaces and colloids, 35(30), 9848-9857 (2019-07-04)
Hopanoids are pentacyclic molecules present in membranes from some bacteria, recently proposed as sterol surrogates in these organisms. Diplopterol is an abundant hopanoid that, similar to sterols, does not self-aggregate in lamellar structures when pure, but forms monolayers at the...
Silène T Wavre-Shapton et al.
Human molecular genetics, 24(24), 7060-7074 (2015-10-10)
Retinal degeneration and visual impairment are the first signs of juvenile neuronal ceroid lipofuscinosis caused by CLN3 mutations, followed by inevitable progression to blindness. We investigated retinal degeneration in Cln3(Δex1-6) null mice, revealing classic 'fingerprint' lysosomal storage in the retinal...
Jun Takagi et al.
Developmental cell, 49(2), 267-278 (2019-04-16)
The microtubule-based spindle is subjected to various mechanical forces during cell division. How the structure generates and responds to forces while maintaining overall integrity is unknown because we have a poor understanding of the relationship between filament architecture and mechanics....
Courtney K Brock et al.
Nature communications, 10(1), 1044-1044 (2019-03-07)
Epithelial tissues require the removal and replacement of damaged cells to sustain a functional barrier. Dying cells provide instructive cues that can influence surrounding cells to proliferate, but how these signals are transmitted to their healthy neighbors to control cellular...
Solène Debaisieux et al.
Nature communications, 6, 6211-6211 (2015-02-05)
Most macrophages remain uninfected in HIV-1-infected patients. Nevertheless, the phagocytic capacity of phagocytes from these patients is impaired, favouring the multiplication of opportunistic pathogens. The basis for this phagocytic defect is not known. HIV-1 Tat protein is efficiently secreted by...
Preeyam S Patel et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5838-5850 (2015-05-10)
Currently, ∼20% of the global population suffers from an allergic disorder. Allergies and asthma occur at higher rates in developed and industrialized countries. It is clear that many human atopic diseases are initiated neonatally and herald more severe IgE-mediated disorders...
Je-Wen Liou et al.
PloS one, 6(5), e19982-e19982 (2011-05-19)
Recent research shows that visible-light responsive photocatalysts have potential usage in antimicrobial applications. However, the dynamic changes in the damage to photocatalyzed bacteria remain unclear. Facilitated by atomic force microscopy, this study analyzes the visible-light driven photocatalyst-mediated damage of Escherichia...
Yang Zhang et al.
Journal of nanobiotechnology, 18(1), 69-69 (2020-05-08)
Cell-bound membrane vesicles (CBMVs) are a type of membrane vesicles different from the well-known extracellular vesicles (EVs). In recent years, the applications of EVs as drug delivery systems have been studied widely. A question may arise whether isolated CBMVs also...
Joanna Koziel et al.
PloS one, 4(4), e5210-e5210 (2009-04-22)
It is becoming increasingly apparent that Staphylococcus aureus are able to survive engulfment by macrophages, and that the intracellular environment of these host cells, which is essential to innate host defenses against invading microorganisms, may in fact provide a refuge...
Anke Di et al.
Journal of cell science, 130(4), 735-744 (2017-01-14)
Acidification of macrophage phagosomes serves an important bactericidal function. We show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 is expressed in the phagosomal membrane and regulates macrophage bactericidal activity through the activation of phagosomal acidification. Measurement...
Nichaluk Leartprapun et al.
Nature communications, 9(1), 2079-2079 (2018-05-29)
Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead...
Birgit A Steppich et al.
Thrombosis journal, 7, 11-11 (2009-07-03)
Tissue factor (TF) contributes to thrombosis following plaque disruption in acute coronary syndromes (ACS). Aim of the study was to investigate the impact of plasma TF activity on prognosis in patients with ACS. One-hundred seventy-four patients with unstable Angina pectoris...
Catherine M Buckley et al.
PLoS pathogens, 15(2), e1007551-e1007551 (2019-02-08)
By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role...
Dapeng Li et al.
Oncoimmunology, 1(5), 687-693 (2012-08-31)
Tumor cells expressing TLRs is generally recognized to mediate tumor inflammation. However, whether and how tumor TLR signaling pathways negatively regulate tumor inflammation remains unclear. In this report, we find that TLR4 signaling of H22 hepatocarcinoma tumor cells is transduced...
Florian Oehme et al.
RNA biology, 16(10), 1339-1345 (2019-06-30)
Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more...
Christophe Chopard et al.
Nature communications, 9(1), 2251-2251 (2018-06-10)
Most HIV-1 Tat is unconventionally secreted by infected cells following Tat interaction with phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2) at the plasma membrane. Extracellular Tat is endocytosed by uninfected cells before escaping from endosomes to reach the cytosol and bind PI(4,5)P2. It...
Fancong Kong et al.
Experimental and therapeutic medicine, 10(6), 2093-2101 (2015-12-17)
Microvesicles (MVs) in body fluids participate in a variety of physical and pathological processes, and are regarded as potential biomarkers for numerous diseases. Flow cytometry (FCM) is among the most frequently used techniques for MV detection. However, different handling methods...
Charles T Halfmann et al.
The Journal of cell biology, 218(7), 2136-2149 (2019-05-31)
Cell nuclei rupture following exposure to mechanical force and/or upon weakening of nuclear integrity, but nuclear ruptures are repairable. Barrier-to-autointegration factor (BAF), a small DNA-binding protein, rapidly localizes to nuclear ruptures; however, its role at these rupture sites is unknown....